Reversal of hair loss in Mice with “sugar gel”
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Applying my gel has kept my scalp warm to the touch (without it my scalp is cool).
My gel consists of coconut-glycerine; d-ribose; oxidal (MB/aspirin/caffeine); urea.
I just added dextrose.
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@LetTheRedeemed Have you noticed any more elasticity / malleability to the scalp?
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@OliverCloasov I Haven't really checked. I'll let you know, but IDK if there will be much improvement on that front, as I've done scalp massages and used decalcifying substances on my scalp for a while now: t3, sodium thiosulfate in DMSO, scalp massages, and red light. I like the idea that the missing component was actual fuel reaching the target area (all stimulators and no fuel to produce ATP and youth hormones).
But, I suppose as bloodflow increases, tissue density should also increase? ...maybe increased elasticity is a thing to look for nevertheless. -
@Hearthfire said in Reversal of hair loss in Mice with “sugar gel”:
@wester130 Just using google ol' white table sugar and honey.
I haven't done too much searching, but I doubt many people have done a long term attempt at applying sugar for regrowth and been consistent at it. The nature of it is just too messy for people to deal with.
This is the conversation Danny Roddy had with Ray Peat:
Danny Roddy: Okay, that makes sense. I read a few times, Kealey. I might be saying his name wrong. Adachi and a few of the other hair loss guys talk about how the hair follicle is extremely glucose-dependent and that it needs a source of glucose. Then a few other people say it's relatively independent of the circulation of glucose in the blood. They were thinking that the glycogen was part of that independence, but if the circulation is reduced from the low thyroid function and the oxygen supply is reduced, the hair follicle obviously suffers. That's where the oxidative stress and lipid peroxidation come in, really harming ... Go ahead.
Ray Peat: Yeah. All of the stresses tend to interfere with glucose oxidation. When you're stressed, you liberate free fatty acids as an energy source, but those poison the ability to oxidize oxygen, so it creates a local diabetes. Have you heard anything about whether diabetics have more baldness or less baldness?
Danny Roddy: I read that the insulin resistance, so-called, is related to baldness. Then somebody on one of my YouTube videos said that he had worked extensively with type 1 diabetics who were all using insulin, and he was like, "I've never noticed any of them being bald before." I don't know if that was accurate or not.
Ray Peat: I've been thinking that with a concentrated glucose solution, you could probably activate hair growth just by keeping your scalp moistened with glucose.
Danny Roddy: That's funny because people have emailed me that, asking if that was a viable therapy. I was like, "I have no idea. I don't know how that would work." It made me think of when you would say things like people use honey for scars and things like that. Go ahead.
Ray Peat: People are actually suggesting applying insulin topically to the skin, but that's a relatively much bigger molecule than glucose. I think there's a chance that either of those can get in, in a quantity that could help.
Danny Roddy: The insulin is helping by what? Stupid question but just supplying the hair follicle with glucose?
Ray Peat: With energy, yeah.
Dexstrose powder would probably be even better than sugar, as it's pure glucose right?
I forget exactly where I got this, probably raypeatforum, but Peat hinted at topical agmatine for hair.
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@Mossy woah nice. Thanks for sharing
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@wester130 thanks for the link
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@LetTheRedeemed said in Reversal of hair loss in Mice with “sugar gel”:
@Mossy woah nice. Thanks for sharing
You're welcome.
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Personally, I wouldn't recommend applying urea to your scalp. My hair is/was at its worst state ever, and this was the culmination of applying urea to my scalp for over a year (among many other factors.) It's my understanding that urea denatures collagen. My hair is improving since I ditched urea and started applying vitamin C to my scalp, which is an action that I took in an attempt to reverse the perceived damage done to my face/scalp skin wrought by urea. Vitamin C is, of course, considered supportive of collagen formation; as are red light and needling, which are common hair loss treatments.
In keeping with the topic of the thread, I am also currently applying dextrose to my scalp on a somewhat regular basis. I will let you all know if anything significant seems to happen.
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@Gaston i do something very similar and apply lysine to the scalp, another builder of collagen
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@Gaston Oh wow good to know. Thanks for sharing!
I've stopped urea use on my scalp posthaste. In light of what you mention, I'm thinking of using urea on some skin growth spots on my body (particularly skin bumps under my eyes I got when I did carnivore and got deadly allergies). Do you have thoughts on that from your research?
Would you mind sharing what improvements you've noticed from increasing pro-collagenous supps to the scalp?
Also, I've been thinking of finding a good ascorbic acid/vit c powder for a few years now, and this has convinced me to pull the trigger -- do you have a source you'd suggest?
Many thanks for your contributions, Gaston!
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@wester130 have you noticed any symptoms of improvement?
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@LetTheRedeemed I don't want to influence you too much because I'm honestly not very knowledgeable. You can continue using urea; just make sure to report back to us if it seems to harm your hair density.
I'm getting slight regrowth on my temples, but that could be due to a dozen different factors.
I use C-Salts Buffered vitamin C. I can't recommend it for any particular reason, it's just what I've always used.
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@Gaston gotcha. Thanks for sharing.
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@Hando-Jin Do you have a quote?
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did anyone buy it from ebay?
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@LetTheRedeemed Have you seen any improvement since your last update?
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"Ray Peat: I've been thinking that with a concentrated glucose solution, you could probably activate hair growth just by keeping your scalp moistened with glucose."
https://dannyroddy.substack.com/p/lost-conversations-with-ray-peat
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@Moonpeat, hey, I essentially gave up after 3 weeks. I realized that as much as I may not like it, I have more pressing health issues to fix first
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I want to mention the anti-prolactin angle again on this thread.
I think applying an anti-prolactin chemical topically to the scalp , should be very effective.
I'm thinking about lisuride, bromocriptine or 5aDHP, which isn't just anti-prolactin but also a progestogen so even better.Dare to think.
My X:
x.com/Metabolicmonstr -
@Mauritio I've been applying bromocriptine to my scalp on an irregular basis for quite awhile and I can't say that it's produced any miracles.
