Methionine/Cysteine restriction increases longetivity AND energy expenditure

Serotoninskeptic

@Mauritio Nice, yeah i think this is definitely the most effective and safest way to go about restricting protein. Instead of restricting total protein very low like Ray did in his later years you can instead have periods of fasting from protein while still meeting your protein requirements overall.

Ecstatic_Hamster

We’re taking a 200 µg dose every other day be reasonable? It’s difficult to get anything but 200 µg dose.

Mauritio

That's what I ve been suspecting. There is a threshold for the benefits. There is a subjective switch that I feel when Im on MR.
This implies that until the threshold there is no harm and after the threshold the harm increases disproportionetly from consuming excess methionine. That is the problem with the intermittent approach @Serotoninskeptic . I think it is a good idea to limit protein to one meal mostly, but overall protein intake shouldnt exceed 40-70g for most people. Thats at least my current opinion.

This is from Peats last Newsletter. His last gift to us.

"There is a threshold effect in exposure to
the harmful amino acids, and this involves a
very sensitive system for detecting their concentration, apparently involving the actin filament network throughout the body. Above
the threshold concentration, methionine
activates mTOR. Increased mTOR shortens
life-span and increases the processes of aging.
Increased fat in the diet increases mTOR,
adding to the effects of amino acids. "

"The way these regulators of energy and
aging interact is holistic, and it’s necessary to
understand that organisms make generalizations about their problems. Things that inhibit
mTOR will increase adaptation and organization with expansion of the time horizon, while
things that activate it (methionine, estrogen,
radiation) will accelerate cell growth and
inflammation and activate terminal processes.
Progesterone and estrogen relate to the degree
of mTOR activity through the body as a
whole, not just through a series of receptor
intermediates."

Serotoninskeptic

@Mauritio Yeah this makes sense. Also in the later years of his life Ray clarified that 100g+ would only be useful for an active young person with a 4-5k calorie metabolism. So, the needs decrease with aging as well as with slower metabolism, and activity level. Someone like me who is young in my 20s and active, lifting weights and maintaining at 3.5k-4k calories. I might need close to 100g or more but intuitively I tend to be around 80-100g and don't really go over that. Im still able to build muscle on this amount.

Mauritio

@Serotoninskeptic yes! He never gave out a recommendation to eat just 50g of protein. It's context specific.
For someone like you it might indeed be necessary to get more than 70g of protein.
I intuitively eat 60-80g if I don't restrict myself.
But I feel like the "threshold" is lower for me. I only feel the switch when I'm around 40-50g per day.

Serotoninskeptic

@Mauritio Yeah I even noticed a huge boost in metabolism and overall energy going from eating 150-200g down to around only 80-100g and increasing my carb intake even further. Most muscle building benefits stagnate around 1g/kg or 1.2g/kg of body weight.

Mauritio

@Serotoninskeptic And muscle building isn't everything, maybe one can build a little more muscle on a way higher P-diet, but at what cost?