Aspirin in the morning vs aspirin at night
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The study below found a difference in the physiological effects between taking aspirin in the morning vs aspirin at night after 4 weeks.
First by way of background, renin is a protein secreted by the kidneys that activates the renin-angiotensin-aldosterone system, which increases blood volume and blood pressure. (see Renin - Wikipedia)
Discussion
Previous studies showed that treatment with aspirin may decrease blood pressure when given at bedtime, whereas administration of aspirin in the morning slightly increased blood pressure.8,9 However, until now, a biologically plausible explanation of this striking phenomenon was not revealed in a clinical study. We specifically conducted a randomized, double-blind crossover trial among grade 1 hypertensive subjects to study the underlying mechanism of the potential blood pressure–lowering effect of aspirin at evening but not in the morning. Our main finding is that aspirin administered at night compared with intake in the morning statistically significantly diminished plasma renin activity over 24 hours, as well as excretion of cortisol, dopamine, and norepinephrine in 24-hour urine.
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Gold.
Thank you DavidPS.
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@DavidPS good find David! Thank you
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@DavidPS
For the objective of the study of lowering hypertension, taking aspirin at night would be preferred. Can it be assumed that for some, morning may still be better, e.g. those with lower BP, and maybe lower pulse? -
Some peculiar things are supposed to happen to the vasculture while we sleep. Or maybe it's just while we're horizontal. Vascular tone relative to blood volume. Or something.
I'll refresh and come back with receipts.
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@Mossy said in Aspirin in the morning vs aspirin at night:
@DavidPS
For the objective of the study of lowering hypertension, taking aspirin at night would be preferred. Can it be assumed that for some, morning may still be better, e.g. those with lower BP, and maybe lower pulse?This is another instance of one size does not fit all.
For the objective of the study of lowering hypertension, taking aspirin at night would be preferred.
Despite some suggestions in the text, this was not a high blood pressure study. Do the reported blood pressure numbers look significantly different to you?
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@ThinPicking - I wish you the best of luck with your quest. I looked and I could not determine what was going on.
I did notice that aspirin at night suppressed the spike in renin activity that was seen with aspirin in the morning. I do not know if that spike was caused by aspirin in the morning or not; there was no graph showing the effect of no aspirin.
Hint - I noticed that the renin activity shown with aspirin in the morning seemed to coincide with the well known morning cortisol spike. Does aspirin at night suppress this response?
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@DavidPS said in Aspirin in the morning vs aspirin at night:
Despite some suggestions in the text, this was not a high blood pressure study. Do the reported blood pressure numbers look significantly different to you?
I did not dig into the study, but was basing my question off of the Discussion you posted, where they say blood pressure was reduced:
"Discussion
...Our main finding is that aspirin administered at night compared with intake in the morning statistically significantly diminished plasma renin activity over 24 hours..."I feel wiped out after night aspirin, and my question was an attempt to avoid lowering blood pressure, by taking it in the morning. I may be able to answer my own question with the chart you provided, which shows the greatest non-lowering advantage in BP was at night, from a morning dose of aspirin, with smaller advantages in the morning. So, if I'm interpreting this correctly, a slight advantage with morning dose with regard to BP not going too low.
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@ThinPicking Thanks for the info. Please don't trouble yourself too much.
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@DavidPS - Thank you. I made the switch from aspirin in the morning to aspirin in the evening. It took almost 4 weeks to notice the sleep benefits.
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@otto -Awesome