A combination of vitamin B1/B3/B7 and aspirin, has curative effects on human mantle-cell lymphoma
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@haidut said in A combination of vitamin B1/B3/B7 and aspirin, has curative effects on human mantle-cell lymphoma:
one "standard of care" treatment
awesome
I'd love to see the "standard of care" proven beyond a shadow of a doubt to be relatively ineffective versus B vitamins and aspirin, your work is very inspiring -
I thought of a possible critique of this study design:
since these are human cancer cells being injected into mice, is it possible that their immune systems are simply fighting the cancer as if its an external pathogen whereas if the cancer was of the mice's own cells, their immune systems would not be fighting as hard against the cancer cells?
ie is it possible that the vitamin combination plus aspirin is simply bolstering the mice's immune systems instead of causing apoptosis via the restoration of OXPHOS?
Not saying I believe this to be the case, but I think trials in organisms whos cancer is induced in their own cells would be necessary to rule out the possibility completely. -
Biotin is quite useful and most people probably don't get enough as per CMJ anywhere from 150mcg into the mgs doses might be needed depending on context which is impossible to get from diet alone. If estrogen is high and pushing down the pedal on acetylcholine production then b1 becomes more complicated to supplement so biotin becomes a good way to help with glucose oxidation in that scenario (among with loads of other benefits too) until b1 is more viable potentially
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@haidut ok and for how long?
By the way I saw that you´ve been chating about Ketotifen and I had experience with it when I had cold allergy and pernioni. Well it took 3 winters on it and I could like year and half in Finland without a problem besides the lack of sun, or too much sun in the summer nights, too much fish and sugar everywhere in the food /marinated sweet fish/ lolll -
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@gas_them_all Another keyboard warrior I see
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Google sheets template to calculate human dosage by weight https://docs.google.com/spreadsheets/d/1qRtb8T7HLw6P1P0EgDq7jaq9Fj-vGAYcbwaoINGJbcA/template/preview
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Very glad to see you here Georgi!
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I’m on week three of this protocol personally. Trying to cure a nodule I’ve had on my thyroid for about 10 years. The first two days I felt incredible, and then day three or four I needed to increase caloric intake SIGNIFICANTLY. For example, I’m 42, 205lbs, lift weights, and typically eat 3200-3500 calories. I’m running 3800-4200 now to keep from getting dizzy/nauseous, (what for me are low blood sugar symptoms).
Anyone interested in trying this just be aware that this dose of Bs with aspirin gave me very noticeable low blood sugar symptoms. Keep food handy! That said, I look forward to where I’m at end of April. We’ll see…
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@evan-hinkle Awesome to hear, and best of luck for the next few months. Are you now maintaining weight on 3800-4200 kcal?
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@haidut
That much aspirin can irritate the gut.
Would mildronate work as good or even better than aspirin? -
@OxidisedOolong yep, weight is holding steady, I’ve also noticed that I don’t seem to need the upper end of the calories anymore, (I’ve had to really be cognizant of whether I’m eliciting a stress reaction or not, and eat accordingly). I’ve settled more into the 3800 calorie side of the equation, (maybe the additional ATP let my body upregulate an immune response temporarily and I just needed more calories to get over that hump?).
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@evan-hinkle Cool, that's great to hear - solid evidence that it raised your metabolic rate.
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Just a quick update:
I have a sensation of much more room in my throat, (in the past swallowing has been difficult, and it’s always felt very tight in my throat due to the nodules).Clicking that I used to experience when swallowing has gone away, ( I assume again this had to do with a lack of room in the throat to perform swallowing correctly).
In general I feel as though the experience has been positive, and I’m not sure I would attribute any negative effects to it thus far. In the interest of being transparent, (after being a terrible sleeper for many years) I have become, since finding Peat’s work, a great sleeper. Since embarking on the B vitamins and aspirin regimen, I am finding that I’m waking maybe once a night, (sometimes not) and this is new for me having slept through the night for about three years now. Typically I remedy this with a little ice cream or an 8oz glass of milk. Just wanted to mention it since it seems to be related. I’m also regularly, but not nightly, taking .5 mg of cypro to help with the sleep issues.
I’ll be three months in at the end of April.
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@evan-hinkle how’s it going bud? Any further improvements or positive things you’ve noticed?
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@haidut said in A combination of vitamin B1/B3/B7 and aspirin, has curative effects on human mantle-cell lymphoma:
Yay, my first post here!
Wanted it to be about the recent study I did. While the results will have to be replicated with a follow-up experiment, with more animals, and additional groups for comparison, this results has never been seen before with this tumor type, which is 100% lethal and has no known case of spontaneous regression (i.e. disappearing on its own, without treatment). Basically, 2 out of 3 animals were fully cured in this experiment/study.
https://twitter.com/haidut/status/1751716166387597730Human-equivalent doses for the substances were ~15mg/kg vitamin B1 (thiamine Hcl), 30mg/kg vitamin B3 (niacinamide), 1.5mg/kg vitamin B7 (biotin), and 15mg/kg aspirin. Administration was once daily, orally.
Good for those who can handle a B vitamin complex !
I can't, whether metylated or not, it makes me anxious, nervous and depressed.
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All 3 mice are now fully cured and cancer-free.
I dont know why Georgi isn't making a bigger deal out of this. Because this is a big deal.
https://x.com/haidut/status/1758122576411279659
https://x.com/haidut/status/1777337478636007790
Dare to think.
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@Santosh said in A combination of vitamin B1/B3/B7 and aspirin, has curative effects on human mantle-cell lymphoma:
Good for those who can handle a B vitamin complex !
I can't, whether metylated or not, it makes me anxious, nervous and depressed.
I have the same exact problem. I can handle them once every 1-2 weeks, but if I take B-vitamins on a daily basis I quickly get bonked out.
