Reversal of hair loss in Mice with “sugar gel”
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@CrumblingCookie i eyed it to approximate amounts as Mauritio’s comment.
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i disagree, pinching the top of your scalp is impossible, especially if it is already damaged by fibrosis
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@wester130 i think we’re talking about two different types of massage intensity. I began just rubbing by pushing my fingers to the top of the scalp to make it feel good, and trying to move the scalp from side to side, as if to stretch (pleasure is a good sign of a safe stimulation imo). With time, moving the scalp can become a small victory. I can now pinch my scalp skin between two fingers on my well rested days, but many days i cannot… i just rub my fingers on it and move the skin how ever much it will.
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Alright, everyone. I've a few new things to tell and stimulate further thoughts on across a couple of topics.
I've ordered various ingredients for blending a new, novel batch of enhanced glucose hair tonic. Which I hope to engage in and report of soon.
Wrt to the very good properties of butyrate, I've come to experience the downside:
After adding only a few drops of tocopherol to my previous mixture, the strong sour-buttery smell has appeared. It really lingers in the hair and clothing. It's not a good smell to go about with in daily life.
That is such a shame.
I'm thinking of replacing the butyrate with smell-neutral apigenin for similar effects.@Mauritio said:
Do you not get weird rancid butter smell from the butyrate. I have dropped it from the newest batch.
@CrumblingCookie said:
Not at all. I had also used the butyrate suspended in water on my arms before and it was fine. Smell-wise it only slightly lingers when blended into oils.
I have a lot to say about the different forms of (pro)vitamin B5 and the widespread problems from use of pantothenic acid in supplements and B-vitamin supplementation in general.
Here's something good and simple from weekly i.m. injections of 500mg dexpanthenol (pantothenol) in human females over the course of two months:
Systemic dexpanthenol as a novel treatment for female pattern hair loss. 2021- "As in the previous series, this study revealed that four-fifths of the patients reported that they observed increased hair growth with DXP."
- "The lack of a control group and the questionnaire-based study may lead to recall bias."
@Mauritio Add generous amounts of dexpanthenol to your blend?
Drink generous amounts of the 75% dexpanthenol liquid every day? It's not at all expensive from the cosmetic ingredient sources.For i.m. injections:
In or from France there's "Bepanthene 250mg/mL inj sol" by Bayer dissolved in pantolactone and water for about €10/6 vials. Very interestingly, it has an official, authorized use as adjunctive treatment of diffuse alopecia. Noone has ever given me that hint, ever.
It's also simple to make: Buy the pure powder or the pure liquid 75% D-dexpanthol cosmetic ingredient, add sterile NaCl as needed, pull up through a 200nm (or better, if you can find one) syringe filter and off we go. -
Pretty crazy regrowth in that first example. Interesting that dexpanthenol is sold in certain products as a wound healer. That tracks. Balding = wounding/inflammation on the scalp.
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“D-dexpanthol cosmetic ingredient, add sterile NaCl”
Could this not be effective topically applied with alcohol?
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@LetTheRedeemed said:
Could this not be effective topically applied with alcohol?
Of course! The topical range lies between 2-20% usually. The dexpanthenol salves for wounded skin usually always contain 5%. Contact allergies to it are reported as possible but very rare.
I'd like to apply about 20-50mg per use. Seeing that I commonly use 2.5-4.5ml of my blend per application this could be reached with a 1% dexpanthenol solution.
I presume DEX should be a more beneficial ingredient and of a higher priority than NMN (B3) and am curious about any interjection from Mauritio.
Because DEX readily oxidizes to PA once inside the cell we could even ascribe some direct antioxidant effects to that initial conversion on top of it increasing GSH synthesis after following conversion to CoA.
Side info on dexpanthenol:
DEX is already an alcohol by itself. It can be diluted in water. It has a hydroxyl end group instead of pantothenic's acid (PA) carboxyl group.
The crucial difference I found is that:-
DEX enters cells very easiyl by passive uptake, whereas PA relies on active uptake by shared vitamin transporters which severely limit the amount and whacks things out of balance.
I.e. the uptake mechanism of PA is competitive to large amounts of the other oral or systemic B-vitamins. Most reported is its competition to biotin uptake but folate and others are implicated just as much. -
In short, that's why for topical use we need DEX rather than PA,
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and why DEX is superior and the primary choice also for systemic and oral use. And why use of oral or systemic PA is indeed shite and far from sufficient nor good enough for many conditions.
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The 75% DEX liquid is a very thick, viscous gel.
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Diluted in water it spreads nicely on skin with a texture similar to glycerin, but is quickly and completely absorbed and leaves a "grippy" feel of the skin (as opposed to sticky).
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I tastes slightly sour, alcoholic-sweet. I'm going to drink it from now on at the rate of 2-3g/day. Very conveniently, the 75% DEX liquid is easily available and even considerably cheaper than what PA or DEX raw powders or supplements cost.
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@CrumblingCookie Interesting development.
I recall reading people talking about increased hair loss, after supplementing Vitamin B5 . I think it had to with reduction in biotin's effects since they both use the same Transporter. Biotin would be my next candidate .
Do you know the supposed MoA of dexapenthanol?For some reason I do not get the "cosmetic" benefits I talked about anymore.First I thought it was because my hair was getting longer, but after a hair cut it still seems the same.
Now I'm starting to think it might have to do with the potassium bicarbonate, maybe I'll try a batch without it.Do you notice that your hair is getting more dry or brittle from all the alcohol exposure ?
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@Mauritio
Yes those are the effects of calcium pantothenate (pantothenic acid), which I finally discovered to be an awful therapeutic substance in spite of a strong necessity for it within cells. If you decide to follow the route with PA and biotin you may well get yourself into endlessly unsatisfying daily balancing efforts.
There are stark inter-individual difference in B5 metabolism in people to bear in mind. Hence some folks have consistently different requirements as for their regular amount of B5 intake and its form than others. Plus, there's essentially no free PA in foods anyways but rather CoA, which must be broken down and converted enzymatically which is hugely dependant on a healthy GI microbiome which likely also contributes to its de-novo synthesis to an unknown extent.Do you know the supposed MoA of dexapenthanol?
It's required for acetyl coenzyme A levels so is essential for protein and fatty acid metabolism and synthesis (think mitochondrial and cellular membranes!) and mitochondrial ATP levels. But also for utilization of pyruvate through PDH. Thereby it significantly increases cellular functionings (also of immune cells and their cytokines) and cellular repair and cell prolification.
That also increases GSH synthesis for increased resilience against radiation or chemical damage.
The immunological effects are very profound. Wrt to skin, a B5 deficiency in rodents e.g. leads to severe Corynebacterium (acnes) infection of strains which would be of no concern in a sufficient state.
There's some effect on keratinases and decreasing fibrosis, too.
Deficiency leads to impaired acetylation of proteins (think histones, too). I.e. more Acetyl-CoA means more (re)acetylation.
Also, even though adrenal functions are greatly impaired in response to ACTH stimulation in B5 deficiency, there are strong hints of a deficiency significantly increasing target tissue sensitivity to corticosteroids/cortisol. So even though there's less than normal circulating cortisol it is more detrimental to organs and tissues.
---> To sum up: More ATP, acetyl-CoA, cell functioning and growth and skin barrier integrity, gluthatione, immulogical control (not just anti-inflammatory, but helping to clear actual infections)Do you notice that your hair is getting more dry or brittle from all the alcohol exposure ?
Your hair, or your scalp? If your hair is getting brittle I'd suspect another cause than alcohol. Likely impaired keratin formation unable to keep up. Could be lack of cysteine? Either absolute or functional as in lack of lysosomal cystine release to the cytosol and its conversion to cysteine in which case cysteamine or panthetine would be great.
I haven't noticed increased brittleness but I've probably also used a solution with less alcohol than your blends.What I've noticed after many weeks of using the butyrate+glucose+lactic acid-blend is more dandruff. After I've switched my shampoo to H&S again after a long time my scalp and hair immediately felt smoother and "cleaner". Which is why I'll either keep using that or add the anti-fungal piroctone olamine to my blend.
