Reversal of hair loss in Mice with “sugar gel”
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That's very interesting. More and more I lean towards hair loss being an occult fungal, parasitic, and possibly bacterial infection in the scalp, Probably enabled by an upstream deficiency. Something happens in the health balance that allows our body to be weakened allowing the infestation. Or perhaps it's just a product of the environment we live in. Terrain theory. When people see raised DHT levels in scalp, they blame baldness on the DHT, but that DHT overload is probably one of your body's measures to repair, trying to regrow the hair that's being destroyed by the fungus/parasites/bacteria. It's like a negative feedback loop that becomes worse and worse over time. DHT grows hair everywhere else on the body. I'm not saying high DHT does not add to the negative effect, but it not being the main factor could be why hair loss is such a mystery to this day, because other more serious underlying factors are doing more damage.
Just as another example of how this could go un-noticed by big medicine; rosacea, Apparently they don't know the cause, but doing a bit of research reading anecdotes online, it seems this might also be caused by demodex mites in most cases. People have cured it by applying ivermectin and tea tree oil. Rosaeca patients tend to have a higher amount of demodex mites, yet mainstream medicine doesn't link the two.
If the cause of a condition as prolific as rosacea is unknown to doctors/skincare professionals, and it turns out to actually be demodex mites, I think the odds of many cases (maybe a majority) of balding in men could be caused by occult fungal/parasitic/bacterial infection. Obviously there's other causes but I'm mainly focused on those caused by (allegedly) DHT.
@CrumblingCookie said in Reversal of hair loss in Mice with “sugar gel”:
That guy linked by @Hearthfire who used potassium bicarbonate (antimycotic + for the ion channels instead of minoxidil) also applied diluted acetic acid (white wine vinegar) before and after to enhance scalp perfusion and to (maybe/wishfully) dissolve skin calcium deposits.
Might as well choose lactic acid for that instead? Its use (5%) against acne, rosacea, for stimulating skin collagen and ceramide synthesis and for retaining skin moisture seems very safe and established.
If it were to only benefit the scalp skin even that would be beneficial for the perfusion and nutrient gradient behind the skin barrier. If the skin cells are more stable they wouldn't need to quarrel with HF, DP and stem cells about who get's the glucose and glutamine. I'd consciously deem it wise if skin cells always were to be prioritized over hair.Not really wishfully. Totally plausible, given enough applications over time. Vinegar will dissolve an eggshell in 10 hours. It's also anti-fungal. So you're doubling up on the anti-fungal action as well.
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Any reason to not use NAD+ in a formulation like this? Aren't you using NMN because it's a NAD+ precursor? NAD+ is readily available on Amazon for pretty cheap.
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@Hearthfire Not answering for Mauritio, but NAD+ has a molecular mass of 663g/mol, therefore due to the Dalton Rule, it is too big of a molecule too pass through the skin. NMN has a moleculer weight in the 300s, so it can enter and pass the skin.
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@Mauritio
I see that the recipe calls for Ethanol.
May we safely assume that "Denatured alcohol" (which appears to be ethanol with additives) is not suitable for this recipe? -
@CrumblingCookie said in Reversal of hair loss in Mice with “sugar gel”:
It's just a thought for avoiding the degree of scalp skin disinfection from the ethanol or its alternative of 20-30% propylene glycol. Of which I cannot say how much significance that bears wrt to the skin microbiome.
What's the minimum ethanol concentration for enhancement of absorption?I don't remember the minimal concentration but I remember it should have been even a bit higher than it is now, especially since removing propylene glycol and especially for the apple polyphenols /procyanidins.
I'm not sure the scalp disinfection is a negative thing.
The fungal hypothesis seems more and more reasonable to me and ethanol does have anti fungal effects.This is where the issue with benzoic acid comes in, fungi thrive in low pH environments and if benzoic acids needs that as well, that might not work well.
In fact, potassium bicarbonate is really good at increasing the pH, which is part of its anti fungal effect. So Ill probably be adding this soon . Only topically though, since I don't want to neutralize stomach acid.@CrumblingCookie said in Reversal of hair loss in Mice with “sugar gel”:
Ah well yes sir/m'lady, the results of laboratory analysis of your painfully plucked hairs are in: They are telogen and falling out and we advice you take this agent of chemical castration, brain neurotransmitter and collagen degeneration" - "Gee, thank you, doc. I better heed this because, boy, I really wouldn't know what to do without your great sophistication!"
Lol
@CrumblingCookie said in Reversal of hair loss in Mice with “sugar gel”:
Might as well choose lactic acid for that instead?
That's a good point . at a low concentration there shouldn't be any systemic effects. So lactate seems interesting.
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@AinmBeo yes I looked into that yesterday. And I'll be going for "drinkable" food grade alcohol. It's more expensive, but the other alcohol is purposefully made un-drinkable with a bunch of additives.
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@Mauritio
Yes.
I see a lot of food grade 190 proof sugar cane-based ethanol on amazon. I base that "food grade 190 proof sugar cane-based ethanol" choice on comments on the Peat site about this very issue. That looks right.
But I am going to the local ETOH store (right next to the pot store...next to the cigarette store) to see, is their Everclear 190 proof food grade ETOH cheaper than the same type of amazon product. -
Here's a bunch of people that claim harder water , containing more calcium carbonate, making their hair more healthy .
Interesting observation . Maybe it's the alkaline pH of the carbonate making it anti-fungal?
My hair has drastically lost health and thickness since moving to a city with soft water. Any ways to make my water harder?
https://www.reddit.com/r/Haircare/s/e1hgEg4eHLDare to think.
My X:
x.com/Metabolicmonstr -
I have added potassium bicarbonate to the formula at 0.5% .
Updated formula
D-Glucose: 1%
Apple Peel Polyphenols: 1%
NMN: 1%
Sodium Butyrate: 0.075%
Potassium Bicarbonate: 0.5%
Ethanol: 35%
Water: 65% -
@Mauritio said in Reversal of hair loss in Mice with “sugar gel”:
Any ways to make my water harder?
Putting it in the freezer might help
On a more serious note, I think there are some shower filters that add calcium and magnesium to the water.
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RPF forum member tyw seemed to somewhat agree . At least he saw lactate as the perfect brain fuel. Maybe that's true for hair as well.
Perhaps tissues that are sensitive to peroxidative damage do well with anaerobic glycolisis and using lactate ?!
"NOTE: the brain heavily regulates oxygen delivery to various tissues, and if those processes are disrupted, we can get over-oxygenation and therefore peroxidation of many brain components.
...
SIDENOTE AGAIN: this is one of the reasons I am a supporter of the theory that Lactate is the ideal brain fuel."https://lowtoxinforum.com/threads/tyw-said-something-that-makes-alot-of-sense.15816/post-217831
"Elevated ROS levels in hair follicle cells during the catagen phase facilitate hair follicle degeneration through the regulation of Trx1 and Foxp1 (Zhao et al., 2015). Balding scalps exhibits increased levels of ROS in the dermal papillae compared to non-balding scalps (Shin et al., 2013; Bakry et al., 2014)."
https://www.biomolther.org/journal/view.html?uid=1565&vmd=Full& -
anyone tried menthol crystals dissolved in vodka on the scalp?
feels incredible, cooling but also warming,
really nice
no greasiness like peppermint oil
new formula would simply be
vodka
peppermint crystals
NMN powder instead of niacinamide -
This study might be relevant to this thread.
Intermittent fasting = bad for hair because of increase in free fatty acids, which cause oxidative stress.
This might make biotin an even more attractive candidate, since besides its general pro-metabolic effects it also lowers FFAs.
This study also corroborates the one I posted above showing hair cells are sensitive to oxidative stress.
https://bioenergetic.forum/post/46125
https://lowtoxinforum.com/threads/biotin-decreases-serum-free-fatty-acids.12109/
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@Gaston Nietsche's Superman is stimulated by hairloss
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@LetTheRedeemed lol
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@Mauritio XD
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Final hair loss formula:
menthol crystals
camphor crystals
NMN powderdissolve in vodka to make a non greasy solution
manual scalp massager to stimulate growth
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I tried topically applying some L-Ornithine Alpha Ketoglutarate and it made me smell like a chlorinated pool, or something. So it's not something that I will be able to keep on my scalp throughout the day. Instead I will try to apply it for an hour or so prior to showering, along with dextrose.
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@Gaston look forward to hearing how that goes.
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@Mauritio
I've been using0.5% Butyrate sodium
1.5% Dextrose
1.5% Lactic acid (L(S)+)
1.0% Potassium chlorideand since I didn't have any pure alcohol or propylene glycol at hand I added the above to a store-bought hair tonic containing alcohol, glycerin, panthenol, coffeine, ocimum basilicum extract.
I clearly went on the very generous side with the dextrose concentration. Maybe I'll back down to 1%.Findings:
- This blend works better than what I had used before (dextrose or dextrose+ASS+glycine or the store product by itself).
- What I ascribe to the lactic acid: My scalp was slightly itchy after application in the beginning. Then I seemed to get used to it. Now still again sometimes. It seems in many cosmetic recipes, they just go for 0.5% free lactic acid and 2-10% lactate-sodium. The latter is allegedly much gentler. I may therefore choose to use potassium carbonate next time instead of KCl.
- This blend leads to an odd kind of coating on my hair, though, which can make them look like not been washed for several days. It's not immediate, i.e. when I've applied the solution after a shower in the evening it's all fine and dandy but in the morning it will already appear as if I hadn't washed my hair for at least day or as if I had worked out and sweat. It's not sticky nor does it look dirty or truly greasy, however. Kind of reminds me of the dry oilyness of saturated magnesium chloride solution.
Any idea what causes this? I'm thinking perhaps the combination of the butyrate or salts with the glycerin or alcohol.
Other thoughts I haven't yet deeply looked into or decided upon:
- Dehydroacetic Acid, Benzyl Alcohol
- Benzoic Acid, Sorbic Acid (+Benzyl Alcohol)
- Phenetyl Alcohol
for preservation instead of alcohol + propylene glycol. - Pirocton olamine for antifungal action to take up the discussed topic of skin fungal burdens. This one had been proposed at the old RPF yet without feedback.
- 2% Urea for keratolysis, i.e. better absorption + as a skin humectant.
- Bisabolol for antiinflammatory + antimicrobial action + as a skin humectant + reductant.
- Allantoin for antiinflammatory + proliferative action + mild keratolysis (instead of urea?) + as a skin humectant.
- Vitamin E, racemic acetate or natural tocopherol as a skin humectant + reductant.
- Propolis (extract) for flavonoids for soothing +proliferative action.
