Progesterone inhibits PDH and increases insulin resistance?
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Just googling certain things like “progesterone effect on PDH, or progesterone effect on insulin” gives me conflicting research from what I’ve learned from Peat.
How do we make sense of this within the bio energetic framework?
https://pubmed.ncbi.nlm.nih.gov/28928113/
“Rather, we find that the pregnancy hormone progesterone induces PDK4 (pyruvate dehydrogenase kinase 4) in cardiomyocytes and that elevated PDK4 levels in late pregnancy lead to inhibition of PDH (pyruvate dehydrogenase) and pyruvate flux into the tricarboxylic acid cycle. Blocking PDK4 reverses the metabolic changes seen in hearts in late pregnancy.”
“To clarify the involvement of progesterone in the pathophysiology of insulin resistance during pregnancy, we examined the molecular mechanism by which progesterone affects insulin's metabolic signaling, leading to glucose uptake in 3T3-L1 adipocytes. Here, we show that progesterone causes insulin resistance by multiple mechanisms. Progesterone suppressed the PI 3-kinase pathway by promoting IRS-1 degradation and suppressed the subsequent phosphorylation of Akt. In addition, progesterone inhibited GLUT4 translocation and glucose uptake in a step distal to Akt phosphorylation. Furthermore, progesterone inhibited TC10 activation by suppressing insulin-induced Cbl phosphorylation.”
Any ideas y’all?
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No. 1: the progesterone for this experiment was dissolved in sesame oil whis is very bad.
https://pmc.ncbi.nlm.nih.gov/articles/instance/5722682/bin/NIHMS908838-supplement-311456_Online.pdfNo. 2: no word about the type of progesterone used. Could be a synthetic version which often act as estrogen not progesterone, Peat has written extensively about this.