Bile can serve as a reservoir for funghi, making them harder to treat

[sunsunsun]

@lobotomize fungal infection can cause or increase risk of issues like liver damage or cancer or seizures, I suspect even warts and skin tags. a not-insignificant % of some organ cancers have been shown to have fungal infections as well and treatment of the cancer is more effective by treating the fungal issue too. OP thinks their issue is worth treating via the nuclear route so who are we to judge, especially when doctors generally don't take this kind of stuff seriously unless someone is already in the hospital and doing very poorly already. The potential toxic effect of flucocytosine might be worth it for the increased positive health potential afterwards.

[sunsunsun]

@evan.hinkle would you be a gentlemen and post a link, and clarify that you were taking bps-acetate orally to heal an injury?

[evan.hinkle]

@sunsunsun https://infiniwell.com/products/bpc-lx-pro-spray

This is the liposomal spray I used recently and had a great experience with.

I’ve used their oral preparation in the past as well, but that’s the arginate version, (which you mentioned being less interested in)

[sunsunsun]

@evan.hinkle link to tx doctor reports?

all I mean about arginate form is if someone can't get it , it doesn't matter. im pretty sure the acetate form works like 95% as good even orally

[evan.hinkle]

@sunsunsun the Texas doctor is something I came across a lifetime ago. I can’t imagine I could find it again. I may have heard about it via Jay Campbell’s podcast, (not bioenergetic orientated). Campbell was a somewhat mainstream early proponent of peptides. If it wasn’t there, then it was Ben Greenfield, (this was all pre-Peat for me).

[Mauritio]

@CrumblingCookie said:

Kestose sounds more like an alternative to fat binders if the goal is to lose body fat through constant steatarrhea and bile acid loss. To not be bothered by these changes I reckon one's stool must be quite good already or even on the dry, constipated side.

Not sure, it has the same mechanism as many other things discussed in this thread. Increase in bile acid synthesis. TUDCA does that too.
On top of that it increases short chain fatty acids like butyrate and also F. Prausnitzii, which lowers serotonin and glycolisis and increases OxPhos and salicylic acid.
Since Im more on the constipated side of things I'll give it a go.

[Mauritio]

@yerrag said:

These essentials that contain esters that are generally antifungal: petit grain, lavender, ylang ylang, clary sage, geranium, roman chamomile

Aren't some/ most of them estrogenic?

[yerrag]

@Mauritio said:

@yerrag said:

These essentials that contain esters that are generally antifungal: petit grain, lavender, ylang ylang, clary sage, geranium, roman chamomile

Aren't some/ most of them estrogenic?

Yes, they are. But they're for therapeutic use.
Antibiotics can be harmful, but we take them because usage is limited.
Usage of these is not a lifestyle choice.

[Mauritio]

Made a thread about this topic. Please reply here:
https://bioenergetic.forum/topic/9360/aspirin-causes-intestinal-damage

Interesting study showing that short term admin of aspirin causes intestinal damage caused by an alteration of bile acids and downregulation of the bile acid receptor FXR. Unfortunetly the effect doesnt dissipate with time as with stomach damage induced by aspirin but the intestinal damage was there after 14 days of aspirin admin.

Im not sure why that damage occured because it seems to have increased the more benign bile acids like TUDCA. and dowregulated the primary bile acids as far as i can see.

"In the aspirin-induced intestinal injury model, conjugated bile acids (T-β-MCA, TCA, TUDCA, TDCA, and TLCA) were significantly increased, while CA and CDCA were distinctly decreased."

"...ASA decreased FXR expression in the ileum."

Now that i think about my cholestasis issue have gotten worse around the time i started taking aspirin daily... weird.

https://www.mdpi.com/1422-0067/25/6/3424

---

Heres another study 80% of the people in the aspirin group had intestinal damage, while only 20% in the control group did.

"After 2 weeks of treatment, the percentages of subjects with small bowel pathology were 80% in the Aspirin group compared with 20% in the Control group (p = 0.023)."
https://pubmed.ncbi.nlm.nih.gov/19246922/

__

Heres two interesting editorials highlighting the intestinal damage. But it does not seem to be clear yet how pathological that damage really is.

https://karger.com/dig/article/79/1/42/106092/Is-Low-Dose-Aspirin-Really-Harmful-to-the-Small

https://karger.com/dig/article/79/1/40/106090/Low-Dose-Aspirin-and-Small-Bowel-Enteropathy

[CrumblingCookie]

CrumblingCookie said:

So far there's not a hint of hematological / bone marrow suppression. CBC is as fine as always.

Retrospective addendum on this: At 95mg/kg BW FCy/5-FC daily and peak serum levels just under the therapeutic optimum my CBC showed a mild drug toxicity in the form of eosinophilia and basophilia. I did have a rash on the light-exposed backs of my hands for a few days around that blood-draw. Total lymphocyte and leucycyte counts weren't suppressed, though, which was most important to me.

Overall:
• My sinuses and upper airways have remained much clearer (perhaps itraconazole alone would have sufficed for this?).
• I can't really put it into words but my mental and physiological response to carbohydrates and sweets has distinctly changed to being calmer and more reserved.
• Still feeling dull in my head 10 days after finishing FCy/5-FC.

@evan.hinkle Thanks for your reply wrt BPC 157. Good info on 10mcg/kg BW minimum for systemic effects from oral dosing! I've been pinning 500mcg subcutanously. Had really, really strong reactions to it for over a week, as in purge-like watery eliminations. Several people online report on such initial effects but for < 3 days so I'm clearly offside the usual, again. I also used 500mcg of the s.c. solution orally for three days in a row and that was just too much and seemed wasteful in the face of this ongoing "purging" reaction.
Ideally I'd like to binge on BPC also from the GI side but I don't have enough of it to do so at the moment.