Bile can serve as a reservoir for funghi, making them harder to treat

[Mauritio]

@CrumblingCookie said:

Kestose sounds more like an alternative to fat binders if the goal is to lose body fat through constant steatarrhea and bile acid loss. To not be bothered by these changes I reckon one's stool must be quite good already or even on the dry, constipated side.

Not sure, it has the same mechanism as many other things discussed in this thread. Increase in bile acid synthesis. TUDCA does that too.
On top of that it increases short chain fatty acids like butyrate and also F. Prausnitzii, which lowers serotonin and glycolisis and increases OxPhos and salicylic acid.
Since Im more on the constipated side of things I'll give it a go.

[Mauritio]

@yerrag said:

These essentials that contain esters that are generally antifungal: petit grain, lavender, ylang ylang, clary sage, geranium, roman chamomile

Aren't some/ most of them estrogenic?

[yerrag]

@Mauritio said:

@yerrag said:

These essentials that contain esters that are generally antifungal: petit grain, lavender, ylang ylang, clary sage, geranium, roman chamomile

Aren't some/ most of them estrogenic?

Yes, they are. But they're for therapeutic use.
Antibiotics can be harmful, but we take them because usage is limited.
Usage of these is not a lifestyle choice.

[Mauritio]

Made a thread about this topic. Please reply here:
https://bioenergetic.forum/topic/9360/aspirin-causes-intestinal-damage

Interesting study showing that short term admin of aspirin causes intestinal damage caused by an alteration of bile acids and downregulation of the bile acid receptor FXR. Unfortunetly the effect doesnt dissipate with time as with stomach damage induced by aspirin but the intestinal damage was there after 14 days of aspirin admin.

Im not sure why that damage occured because it seems to have increased the more benign bile acids like TUDCA. and dowregulated the primary bile acids as far as i can see.

"In the aspirin-induced intestinal injury model, conjugated bile acids (T-β-MCA, TCA, TUDCA, TDCA, and TLCA) were significantly increased, while CA and CDCA were distinctly decreased."

"...ASA decreased FXR expression in the ileum."

Now that i think about my cholestasis issue have gotten worse around the time i started taking aspirin daily... weird.

https://www.mdpi.com/1422-0067/25/6/3424

---

Heres another study 80% of the people in the aspirin group had intestinal damage, while only 20% in the control group did.

"After 2 weeks of treatment, the percentages of subjects with small bowel pathology were 80% in the Aspirin group compared with 20% in the Control group (p = 0.023)."
https://pubmed.ncbi.nlm.nih.gov/19246922/

__

Heres two interesting editorials highlighting the intestinal damage. But it does not seem to be clear yet how pathological that damage really is.

https://karger.com/dig/article/79/1/42/106092/Is-Low-Dose-Aspirin-Really-Harmful-to-the-Small

https://karger.com/dig/article/79/1/40/106090/Low-Dose-Aspirin-and-Small-Bowel-Enteropathy

[CrumblingCookie]

CrumblingCookie said:

So far there's not a hint of hematological / bone marrow suppression. CBC is as fine as always.

Retrospective addendum on this: At 95mg/kg BW FCy/5-FC daily and peak serum levels just under the therapeutic optimum my CBC showed a mild drug toxicity in the form of eosinophilia and basophilia. I did have a rash on the light-exposed backs of my hands for a few days around that blood-draw. Total lymphocyte and leucycyte counts weren't suppressed, though, which was most important to me.

Overall:
• My sinuses and upper airways have remained much clearer (perhaps itraconazole alone would have sufficed for this?).
• I can't really put it into words but my mental and physiological response to carbohydrates and sweets has distinctly changed to being calmer and more reserved.
• Still feeling dull in my head 10 days after finishing FCy/5-FC.

@evan.hinkle Thanks for your reply wrt BPC 157. Good info on 10mcg/kg BW minimum for systemic effects from oral dosing! I've been pinning 500mcg subcutanously. Had really, really strong reactions to it for over a week, as in purge-like watery eliminations. Several people online report on such initial effects but for < 3 days so I'm clearly offside the usual, again. I also used 500mcg of the s.c. solution orally for three days in a row and that was just too much and seemed wasteful in the face of this ongoing "purging" reaction.
Ideally I'd like to binge on BPC also from the GI side but I don't have enough of it to do so at the moment.

[Mauritio]

@crumblingcookie
I've tried gentian for the last 2 weeks, which you mentioned in one of your posts.
In the first week of worked really well for bile, also lost some weight and strongly decreased hair loss.
It also made me quite tired, turns out it's a NMDA antagonist.
In the 2nd week the benefits started fading. I seem to develope tolerance once again.
But if I can use this one week on, one week off on the future that's a win for me.

Since this one worked, I'll try some of the other herbs you mentioned like dandelion.

[dapose]

I like Swedish bitters for when I need alittle bile and liver help. This stuff is fantastic for warming you up and easing any liver gallbladder discomfort after eating a fatty meal or just over eating which I’m am know to do now and again.

[VehmicJuryman]

Have any other fungal infectees had an appendectomy in the past? I'm wondering if my inability to permanently resolve this has to do with not having an appendix. If I recall correctly the appendix is supposed to be a refugium that helps repopulate your microbiome when it gets cleared out, maybe not having that makes it too easy for fungi to outcompete bacteria

[sunsunsun]

@VehmicJuryman try replacing it with s. boulardii (florastor etc) . maybe it can out compete whatever yeast it is

[VehmicJuryman]

I know this is pretty basic for a Ray Peat forum but have you all tried consuming large amounts of coconut oil? I did some research on it, apparently it's more effective against fungus in vitro than antifungal drugs like fluconazole. It has a similar mechanism of action as antifungal drugs i.e. it targets the ergosterol in the fungal cell membranes. It's one of the most commonly mentioned natural candida remedies on forums like reddit. Popular anti-candida supplements like Now Candida Support contain caprylic acid which is abundant in and sourced from coconut oil. Coconuts evolved for their drupes to survive in humid tropical coastlines and to float on ocean currents so the fats are probably evolved to be resistant to fungi.

[yerrag]

@VehmicJuryman

The oral intake of coconut oil has the effect of getting the liver to metabolize coconut oil for energy. This leaves little of the antifungal components such as caprylic acid and lauric acid to be distributed by chyomicrons to the cells in the body.

To keep the,liver from metabolizing coconut oil, I have been using suppositories to deliver vco intact to the cells.