Diclofenac gel to regrow hair on bald head and beard

wester130

@Mossy many companies are mixing Minoxidil with treitinoin, so it is positively affecting the collagen

i am not sure of what mechanism, maybe inflammation, maybe improving collagen,

Hearthfire

I think treitinoin helps absorption, but also:

Chat GPT says:

Tretinoin (a retinoid) increases skin cell turnover and thins the outermost layer of the skin (stratum corneum), which can:
Increase scalp permeability
Allow more minoxidil to reach the follicles

Minoxidil must be converted into minoxidil sulfate by an enzyme in the scalp called sulfotransferase.
Some research suggests tretinoin may:
Increase sulfotransferase activity

Some peoples scalps don't have enough sulfotransferase, therefore treitinoin is used topically to convert it.

Alternatively, oral minoxdil can be taken if you're a non-responder to topical, because the liver has abundant sulfotransferase enzymes.

wester130

"In reference to the man who fell in a fireplace and regrew his hair - you can actually get your scalp skin burned off.
It is called a phenol peel, far stronger than an ordinary chemical peel.
It is not sold online, you cannot buy the ingredients, only specialist beauty centers will offer it."

wester130

has anyone ever considered scar gels for hair loss?

there is a lot of overlap with healing the skin and TGFb-1

many of them contain interesting ingredients that would stop inflammation in the scalp

LetTheRedeemed

@wester130 going down the turpentine rabit hole, I googled around and found some research on terpenes supposedly reducing types 1 and 3 collagen -- bakuchiol, according to google. this also said terpenes are used for wound healing. I'm willing to believe that turpentine can straight up strip the collagenous paint out of one's scalp, lol

part of me wants to put turpentine on my head.

LetTheRedeemed

@wester130 oh wow, ultrasound can break down fibrous tissue at the cellular level. There are clinics offering therapeutic scalp ultrasounds for hair health. https://onlinelibrary.wiley.com/doi/abs/10.1002/tee.23866

wester130

some research i am doing on essential oils and vasodilation

rosemary and menthol are not potent, neither is euclayptus, neither make the top 10

patchouliguaiols ,
citral,
carvacrol + thymol ,
eugenol
are the most potent vasodilators if you are looking at isolated chemicals

for patchouliguaiols, spikenard or simply patchouli oil would work

for citral, lemongrass or lemon verbena

for carvacrol + thymol , - oregano and thyme

for eugenol - clove essential oil would work

ginger, cinnamon, capscium, rosemary, menthol don't make the top 10 list.
rosemary for hair is the biggest scam going, look at the science, the chemicals in rosemary do not vasdodilate,

Gaston

@wester130 More horseshit from Big Rosemary.

CrumblingCookie

Rosemary (or sage) is not about vasodilation but about powerful anti-inflammatory activity by its diterpene carnosic acid, which is an antagonist to the human VDR and thus innate immunity. It may therefore work topically (to suppress symptoms for temporary healing but not to cure) for psoriasis and the like.

Hearthfire

@CrumblingCookie

It also kills bacteria and fungus and parasites (e.g. demodex mites). The vasodilation was never the main use for me.

And who cares if it's not the most potent vasodilator? It still produces some vasodilation. That's just a plus.

Anti-inflammatory + anti-bacteria/fungus/parasite + vasodilation. No way that's not going to be beneficial to your hair health/growth.