Random, interesting studies

[Mauritio]

Giving testosterone with an aromatse inhibitor reduces mounting behaviour.
Maybe that explains why androsterone another aromatase inhibitor kills libido for so many guys. Estrogen seems to be necessary to some degree.

https://pubmed.ncbi.nlm.nih.gov/1204576/

[Kvirion]

@Mauritio said in Random, interesting studies:

Estrogen seems to be necessary to some degree.

“Estrogen’s name, derived from the gadfly, accurately suggests its role as an excitant, getting things started. Progesterone’s name, relating to pregnancy, is compatible with thinking of it as an agent of calming and fulfillment. But these properties show up in every aspect of physiology, and the special cases of female estrus and pregnancy can be properly understood only in the larger context, in which, for example, progesterone is a brain hormone in both sexes and at all ages, and estrogen is an essential male hormone involved in the sperm cell’s function and male libido.” ~Ray Peat, PhD

https://www.functionalps.com/blog/2012/07/05/menstrual-cycle/

[Mauritio]

@Kvirion said in Random, interesting studies:

and estrogen is an essential male hormone involved in the sperm cell’s function and male libido

Oh thanks I didn't know that quote.

[Mauritio]

@cs3000 How is your catalase experiment going?

I was thinkinh about using it topically and orally for hair loss.

[cs3000]

@Mauritio i got a powdered one took some time to get. no noticeable improvements so far. in the feeding studies 60d worked better than 30d (both worked well) so there's some time buildup effect. but expected to notice something acute.
this one i have has some black dots mixed into the powder not listed in the ingredients. so some concern considering it can be extracted from a mold. i guess if the mold is dead it could still trigger inflammation?
i tested it in some 6% h2o2 liquid and it fizzed like fuck so the white powder is legit (can do that with some potato slices too much milder response)

Same wondered if it would be good for that, i started putting it on one side of hairline curious to see if it creates regrowth. putting in a bit of glycerine

[Mauritio]

@cs3000 ok thanks for the update.

I'll probably start taking it as well.

[Mauritio]

Baicalin

Increases dopamine and tyrosine hysdroxliase. Possible ADHD treatment.
https://pubmed.ncbi.nlm.nih.gov/30736828/

"...baicalin can ameliorate neuropathic pain by suppressing HDAC1 expression ."
https://pubmed.ncbi.nlm.nih.gov/23684218/

Inhibits carbonic anhydrase II, but also increase Acetylcholin quite strongly.
https://pubmed.ncbi.nlm.nih.gov/38004276/

Outperforms Minoxidil in growth study.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9699788/#sec3

Increases UCP1 AND PGC1a
https://pubmed.ncbi.nlm.nih.gov/35337814/

[Mauritio]

Nicotine acts on thyroid receptors.

"...nicotine and learning uniquely acted to increase TR activation..."

"Acute nicotine enhances learning and these effects may involve processes regulated by the transcription factor TRβ."

https://pmc.ncbi.nlm.nih.gov/articles/PMC4387063/

[Mauritio]

Sodium butyrate downregulates 5HT2a receptor. Has anti depressant effect.

https://pubmed.ncbi.nlm.nih.gov/21812623/

Sodium butyrate increases Testosterone in mice on a HFD. It even exceeded the value of the control group. It also helped with sperm health .

https://tau.amegroups.org/article/view/136309/html#figure1

Increases Testosterone in roosters.
https://www.sciencedirect.com/science/article/abs/pii/S0378432017308321#:~:text=Conclusion,roosters during their fertility peaks.

It increases progesterone and embryo survival .
https://pubmed.ncbi.nlm.nih.gov/31063920/

[Mauritio]

Sulforaphane

Increases FGF21. Ameliorates NAFLD.
https://pubmed.ncbi.nlm.nih.gov/34654875/

Lowers weight gain on a hfd, increases UCP1, lowers scd1
https://pubmed.ncbi.nlm.nih.gov/33995092/

Lowers 5-HT(3A), 5-HT(1A), 5-HT(2C) in vitro
https://pubmed.ncbi.nlm.nih.gov/18593952/

Increases PGC1a
https://pubmed.ncbi.nlm.nih.gov/35955572/

And several impressive human studies on autism. Probably helps because of anti serotonin effect.

[CrumblingCookie]

@Mauritio said:

Sodium butyrate increases Testosterone in mice on a HFD. It even exceeded the value of the control group. It also helped with sperm health .

Dissolve it into a suspension with MCTs or into your favourite water-based lotion and try it on your lower parts or even as general skin care and observe any pleasant short term effects.

[CrumblingCookie]

Colostrum. Reduces and prevents upper respiratory tract infections, flu:

Jones et al[21] reported significantly decreased URTI symptoms and episodes in athletes receiving BC compared with the placebo group.

• "COL limits the increased salivary bacterial load in physically active males during the winter months which may provide a novel mechanism of immune-modulation with COL and a relevant marker of in vivo (innate) immunity and risk of URI. "

Cesarone et al[22] reported that BC reduced flu episodes, and suggested that supplementation with BC might be more effective than vaccination against influenza virus.

• "After 3 months of follow-up, the number of days with flu was 3 times higher in the non-colostrum subjects. The colostrum group had 13 episodes versus 14 in the colostrum + vaccination group, 41 in the group without prophylaxis, and 57 in nontreated subjects. Part 2 of the study had a similar protocol with 65 very high-risk cardiovascular subjects, all of whom had prophylaxis. The incidence of complications and hospital admission was higher in the group that received only a vaccination compared with the colostrum groups. Colostrum, both in healthy subjects and high-risk cardiovascular patients, is at least 3 times more effective than vaccination to prevent flu and is very cost-effective."

And a review of studies on Colostrum Therapy for Human Gastrointestinal Health
and Disease

• "In animal models, bovine colostrum benefits NSAID enteropathy, IBD, and intestinal failure. In human trials, there is substantial evidence of efficacy of bovine colostrum in inflammatory bowel disease and in infectious diarrhea."