The pro-metabolic effects of ultrasound

CrumblingCookie

Thanks for trying anyways.
That would've been my next step, to look for a device with lower frequency.

"Conflicts of Interest

Authors (M.S., S.K.K., F.M., B.B.R. and R.M.) are co-authors of patents related to these studies, and M.S. and F.M. have financial interests in a company, Mechanobiologics Inc. that is planning to market LFU devices suitable for senescent cell rejuvenation in vitro and in vivo."

Researching the schematics and electrical parts list aside I am wondering how that whole-body treatment could be achieved. In the study they placed the mice on top of a plastic mesh on top of a distancing cylinder in a large beaker filled with water, so that the mice were half-submerged in water and in the far-field of the transducer, i.e. in a relatively homogenous ultrasonic field.
Simply dipping a custom-built transducer at the foot end into the bathtub wouldn't be anywhere as homogenous.
Perhaps place a super-wide-beam transducer at the bottom middle of a bathtub and put a plastic sunlounger on top to lay on. Or integrate it into one of those fancy costly floatation pods.

Does anyone know how to convert those 4kPa power approximately to on-skin mW/cm²?

From looking at the supplemental figure 1 one can see that it's well possible to invest time and effort yet to no or little avail by having the parameters just crucially off: Too much pressure/power (anything above 4kPa) and there's no effect. More on- than off-time pulsing and the effects decrease. A different frequency and there are none of the wanted effects. Too little duration and there's no or little effect yet too frequent repetitions of the same and the effects dimish too.
The supplemental table S2 states the us treatment is strongly antiserotinergic: Peatarians, assemble. Whereas I don't know what to make of those strongly upregulated viral infection processes in table S1.

evan.hinkle

I wonder if the water is not playing a role in the 29 month old mice who are showing signs of reversal of age? For instance, water can be structured many different ways, (red light, vortexing, filtering through rock like media). I wouldn’t be surprised if the ultrasound is structuring/energizing the water, and it’s the mice being bathed in this substance that is exerting the effects.

I have heals many maladies in the past simply structuring water and then soaking my feet in that water. For whatever reason that I can only guess about, my best results have always come from using sea-water, (structuring that, and then soaking my feet in that). The results are systemic. A rough patch of skin on say my knee is returned to normal by soaking my feet. An increase in energy, (not driven by cortisol) can be observed by soaking my feet.

I say all of this to say: water may be playing a key role in these findings, (though if ultrasound is capable of structuring fluid, the fluids of the body may suffice too). I just personally have had remarkable success with “bathing” in structured water.