Biotin and liver cancer
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I am interested in taking 10mg biotin because it's a cofactor for PDH, the main enzyme responsible for glucose oxidation, and also for preventing gluconeogenesis.
However, Peat wrote how high levels of biotin (from an interview, >1mg) cause fatty liver and then liver cancer. This is from an old study using lab rats and I can't find anything more on this.
Do we know more about this study or is this cancer risk a big buncha bunk?
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@engineer some of his references are made to make incorrect conclusions
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@sunsunsun said in Biotin and liver cancer:
some of his references are made to make incorrect conclusions
Do you mean generally or on this topic?
It's worth considering we're more lazy and retarded than someone like @8f4. And/or that breadcrumbs are involved.
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Maybe it has something to do with the mechanism behind immunoassay interference @engineer.
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@ThinPicking in general. re: breadcrumbs, I've read one reference of his in an article that explicitly proves the opposite of what he says in the article. like, the study is designed and done and findings explain in such a way that the claim made and the reference to back it is just the complete opposite of what is actually claimed in the article on raypeat website
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@sunsunsun said in Biotin and liver cancer:
one reference of his in an article that explicitly proves the opposite of what he says in the article
Could be a good opener for an rp contradictions thread.
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@ThinPicking I posted in detail about it on here sometime on some account. it's about avocados.
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Fair I'll try to find it.
I don't consider them deadly without a laugh about it. Except that I'm probably not supposed to be able to buy them here. 24/7/365 and a 20 minute walk.
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@ThinPicking in the article where he calls avocados toxic due to the pufa content, references a study that shows they are toxic in the study specifically due to the non-oil component because the study tests avocado oil vs. avocado oil with the avocado polyphenols (or whatever they are) removed and only the avocado oil without the stuff removed causes the issue. so the study itself says the pufa does nothing bad as tested
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https://bioenergetic.forum/post/53285
https://bioenergetic.forum/post/53271I had fun reading these again, thank you sneedster. And no one can argue with you, they may as well argue with a bathroom mirror.
@sunsunsun said in Avocado: Toxic but how much?:
Even the authors of the liver collagen solubility study showing avocado tended to promote fibrosis say they are surprised at their result because their previous study in skin showed the opposite effect.
Something's wrong with the controls in almost all of the literature and we all know it. There were at least 2 whole threads about this on rpf.
This was also highly amusing btw. 9/9 spirited character.
https://bioenergetic.forum/post/63157
@sunsunsun said in Avocado: Toxic but how much?:
Danny Roddy who apparently is le Ray Peat expert never caught this or called him out on it. This is a guy who charges people money for his 'expertise' on bioenergetics.
The hasty pursuit of practical application for chicken farming.
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@engineer from my memory of Peat saying and writing about high dose biotin, it needs to be balanced with Inositol. And that eliminates the liver problems with higher dose biotin. Maybe Georgi had a paper on that.. I take 10 mg of biotin once a week or so and it is really amazing for skin health. We have gotten much thicker youthful skin since we started using the occasional 10 mg biotin.
I’ll try to look for the source of what I’m talking about.
