@BioEclectic Thanks for this, I have had run-ins with some of those things at least a few times over these years.
As an aside, despite this being a gut-focused thread, I still think that my problems must be systemic to some degree. It's been warm here recently, and I've been out in the sun, but it has left me feeling worse. Return of some old CFS-like symptoms, I struggle to socialize and focus, libido is gone again, mood is kind of souring, etc. Thankfully not nearly as bad as it used to be, no dizziness and feeling like I have to take a nap midday, or such. I try to drink and eat sufficiently but I basically have no thirst or hunger cues, which is crazy, but it's been that way for years.
This is why I've been leaning toward things that could have a more broad, "tonic" effect, since it feels I should be tackling all this on some kind of broader level. I used progesterone last year for example, off and on during spring and summer, and although that was a bit rocky it seems to have been a net positive, that's when my body composition and fatigue started changing for the better. Cascara also kind of fits into that kind of idea, especially if the gut situation is a major contributor to the general situation. Bad or unhelpful experiences with most things I've tried has left me using only Haidut's vitamin E, and small doses of vitamin B1 for about a year now.
Anyway - yes I've tried most of those things at some point, and am wary of excipients and more "unnatural" isolated minerals and such. If I had more of a clue what is causing my problems I'd probably feel more willing to try stuff, this shooting in the dark thing is difficult to navigate. Magnesium sounds harmless enough, there's sulfate and hydroxide powder available for purchase near me. I assume you prefer liquid forms?
I think the next thing will be trying cascara again, not being a baby about it and sticking with a regular dose for a while. Maybe progesterone at some point but I'm still skittish.