Posts made by Hearthfire

@BearWithMe wtf? that's insane regrowth

@jamezb46

So would you recommend just ditching ubiquinol and use regular CoQ10? It is cheaper, which is nice.

I'm still taking Ubiquinol, at 300mg per day right now.

I can't say for sure yet if it has helped with any hair regrowth (why I'm taking it in the first place), because I do have regrowth that was happening before taking ubiquinol. I've been microneedling, using a regrowth shampoo, nizoral, and some other things. If it has helped it's not apparent yet, I'm guessing I need to be on it for at least a few months to notice a difference. The guy from that hairloss talk thread was on it for 4-5 months before he noticed it.

Just got some CoQ10 at Costco, 300 mg per pill. Going to try that when I run out of Ubiquinol. Or maybe I'll start taking one of both forms per day at different times, just to cover bases. That would be 400 mg.

As far as effects I HAVE noticed, I would say it has definitely helped with energy levels. Workouts feel a lot better lately. Not getting tired during the day.

@the_black_jew

Why? I thought it was well established ubiquinol was better.

@BearWithMe

Yeah, I did a little reading into it, it seems to be from oral pills at moderate to high doses.

Other NSAIDs people take have similar side effects, but millions of people take them every day without issue.

I think topical is probably safe.

@BeefEnjoyer

Being overweight is what is debilitating to health. It makes you more prone to infections and pretty much all other ailments. Heart disease, diabetes, high blood pressure, cancer.

If your body is trying to fight something off and heal, and it's causing this debilitating salivation, then it's obviously not able to for some reason.

If you're not willing to make major changes to try to fix it, it must not be that debilitating.

@wester130

I did a bit more reading on the side effects, the crazy stuff like heart attacks seems it's related to people taking it in tablet form in fairly high doses, and it's because it raises your blood pressure.

I don't think rubbing the gel on topically would cause an issue, not anymore than nizoral/minoxidil and some of the other things people use topically. Since you can now buy the gel on freakin' Amazon without a prescription, I imagine it's very safe to use topically.

People take NSAIDs all the time that increase the risk of heart attack. Doesn't mean it will. If you're not healthy, by all means avoid it.

@wester130 Powerful anti-inflammatory action. Whatever is going on in the scalp that causes the inflammation, it reduces that inflammation effectively, and allows hair to grow again. Could be the lowering of pgd2.

This post from a thread on hairlosstalk seems to hit the nail on the head

If you look at the mechanism of action, it inhibits cox as most NSAIDs. Means it lowers also the beneficial pge1, pge2 and pgf2a. However bald scalp mostly expresses pgd2 and low pge2, makes sense that there is overall a beneficial effect. Story changes probably once you want actual regrowth, and are already taking finasteride/dutasteride/ru etc and also start more targeting of that pathway (crth2 inhibitors, pge2, pgf2a analogues...). I guess one could in fact try diclo plus topical pge analgues (you probably at least want pge2 analogue plus castor oil and in addition some potent pgf2a like chloprostenol) to avoid this issue and save some money on seti etc (and avoid the non-responder issue with crth2i therapy). I also would avoid diclo while woundling, as inflammation triggers the growthfactors which makes it even less practical as pgd2 and crth2 inhibit wound induced hf neogenesis.

https://www.hairlosstalk.com/interact/threads/diclofenac-now-available-over-the-counter.127444/post-1874753

I bet pairing it with castor oil taken orally would be a powerful combination.

The ricinoleic acid in castor oil is a potent pge2 agonist, it stimulates pge2, and potentially has an antagonizing effect with pgd2. Pge2 promotes relaxtion of tissues, pgd2 promotes constriction of tissues.
Good video from More Plates More Dates on the subject:
https://www.youtube.com/watch?v=rOnK9bX5TLM

So you lower the high balding scalp levels of pgd2 with the Diclofenac gel, then take castor oil to promote pge2, and get even more pgd2 antagonist action.

@BeefEnjoyer

Overweight people are more prone to infections. Maybe not the cause, but I would start trying to get your weight down anyway. It will vastly improve your overall health even if it doesn't fix the hypersalivation.

If you suspect it's a infection/gut issue, gotta start trying stuff. For the mouth, try salt rinses, baking soda rinses, to clear up bad bacteria, great for teeth health overall. Also put a teaspoon of baking soda in a glass of water and drink it daily. Will help with the bloating/gas, helps with acid reflux. Tons of health benefits to it.

Are you taking medications? Google search says over salivation is usually caused by medications.

@wester130

That does make me reconsider trying it. Impressive.

@BeefEnjoyer

How much do you weigh?

@Mossy Yeah, makes me reconsider trying it. Also in that hairloss talk thread, someone said a bunch of people tried it and it wasn't that great. Who knows how they did it or if they were consistent.

I might actually just skip trying this one.

@Mossy What sides did you get with Nizoral? I tried it for a month and it was fine. I even used it way more often than people say to (once per week, I sometimes did 2-3). No issues. Going to try it again because I think it did help increase growth.

@Gaston This is why I think it has huge potential if done with consistency. How many people have tried this for any real length of time? Most probably quit because it's "messy". Seems like a fairly obscure thing that not many have probably tried with any real consistency for more than a few months.. The few anecdotes and studies show huge potential though.

There are tons of people who won't even stick to using minoxidil regularly because 1. it's tedious 2. it's messy, and then just stop completely because they didn't get results (because they were inconsistent), even though it's scientifically proven to work. How many more would have tried something esoteric (as far as hair regrowth treatments) like Diclofenac, it sounds much messier than minoxidil.

@Mossy

Found some studies that support that Diclofenac works. Minoxidil, Diclofenac, and Tea Tree Oil microemulsion worked far better than minoxidil alone.

https://pmc.ncbi.nlm.nih.gov/articles/PMC3686323/

In their conclusion, they say this indicates that androgenic alopecia is multifactorial. I have come to that conclusion myself. I think it's a cascade effect of multiple things leading to baldness. Two big ones I think people aren't addressing enough is fungus and Demodex mites, which the tea tree oil would address. Then you have that powerful anti-inflammatory action from the Diclofenac.

You could probably achieve the same results from just applying all three at different times throughout the day.

Heres another study with pictures: https://www.researchgate.net/publication/302483501_Topical_Diclofenac_3_Gel_for_Actinic_Keratosis_May_Induce_Terminal_Hair_in_Male_Androgenetic_Alopecia_A_Report_of_Three_Cases

If it works that well for someone in their 70s who has been bald for a long time, I imagine it works much better for a young man.

@Mossy can you link the article with the comment?

@DkJoe2 Scalp massage/microneedling to heal/break up the calcification.

I bet pairing scalp massage + microneedling + diclofenac gel would be quite effective. I'm already seeing results from microneedling + massage and a homemade regrowth shampoo, will definitely be trying this diclofenac gel.

@DkJoe2

Why would it work any less on the scalp? It's not like the calcification is impenetrable and everywhere. Diclofenac gel is designed to penetrate skin and relieve pain caused by inflammation. Something is causing inflammation/calcification of scalps which leads to baldness, so if you take away the inflammation with an effective NSAID, it makes perfect sense hair would regrow. Maybe it's causing the scalp to loosen, because of the reduced inflammation.

I doubt many people have tried it for hair regrowth because it's for arthritis. Which is always promising.

I'm gonna add it to the list of things to try. Sounds very promising.

Looks like you can just buy it off amazon

https://www.amazon.com/Arthritis-Diclofenac-Extra-Strength-Anti-inflammatory-Treatment/dp/B09FYC526N

Burning will damage your skin, but how much depends on the severity. You can completely heal from it.

Low Vitamin D and using sunscreen is what causes cancer and aged skin look.

@Sitaruim No it isn't. Sun is good for your skin. Sunscreen is what fucks peoples skin up.