Posts made by LucH

The skin problems are directly connected with the dehydration. That I'm sure of. I don't really eat vegetables.
=>

1. If you drink enough during the day light, you can’t be dehydrated because of sleep unless there is another problem.
   You don’t take into account what I’ve said about supplement for skin repair: GLA and Zinc are the most susceptible to lack. And don’t tell me you’ve got enough zinc when eating red meat (not the other kinds) because you’ve got a problem of assimilation: bad digestion and low-grade stomach inflammation.
2. You’ve got a problem with potassium if you don’t eat vegetables. Problem with electrolytes.

Fruits must be eaten apart.
You mean separate from other food types? Why would that help?
=> Fruits bring soluble and insoluble fibers and sugar. Sugar raises fermentation. As you suffer from bloating, so it’s easy to make the link.
Most fruits and vegetables are digested in less than half an hour. If you eat first starch and meat, fibers will remain longer (2-3 hours) in the first part of the colon than what is needed.

And your temp won't be OK without appropriate protein (from meat preferably).
Check my list under diet above, more than adequate protein is being consumed.
=>Your list is approximate and doesn’t say much about the quantity and the frequency. And what about the balance from amino acids:
“Beef mince 15-20% fat, organic eggs, chicken feet, ox tendon, sometimes chicken breast, sometimes lamb liver, chicken livers, lamb heart, lamb kidneys”.
=> Red meat: 2x/wk (I suppose), liver or meat organs 1x/wk, chicken 2x or 3x/wk.
Advice: See how much protein (amount in grams) with cronometer.com.
0.8 gr minimum / body weight. 1 gr target.
I would add: duck.

See Dr overtone why you need more thiamine (B1) to help carburation.
Under supplements above, B1 was listed.
=> You didn’t say how much and what type. It’s not with 50 mg Thiamine HCl you’re going to re-connect the brain and the microbiota through the vagus nerve.

But you have first to deal with dysbiosis.
Not sure if I do have dysbiosis or not but that could be causing malabsorption if I did.
Yes, you have if you bloat and have flatulence. Your digestion is problematic.

Final note:

I won’t discuss any longer why and how. You’re not receptive enough and I need to see the person accessible to optimize my “time invest”.
You should have asked why or how if you didn’t perceive the reason instead of arguing. Sorry to be hard but …
Take care of you and stay open-minded.

Hi,
If you don't drink enough water (1.5 liter) + vegetables, you won't recover. Water is worth more by what it takes away than what it brings.
For skin problems, mind the following nutrients:
Monitor vitamin A (Retinol) and vitamin B-co-enzymed (notably B3 Niacinamide and B5 Panthenol) + zinc (10 to 15 mg; double the dose for a few days). + GLA (evening primrose oil 500 mg if you're a girl).

But you have first to deal with dysbiosis.

Otherwise, it won't succeed.
And I 'd take digestive enzymes to help.
Fruits must be eaten apart. When OK, may be eaten at first (salad), following 15' later by other macronutrients.
It's like a treasure hunt, search for elements that helps or harm.
And your temp won't be OK without appropriate protein (from meat preferably).
See Dr overtone why you need more thiamine (B1) to help carburation. But not now.
Hope it can help.

@haidut said in Fish oil (omega-3) causes, not prevents cardiovascular disease (CVD):

using fish oil on a regular basis might actually increase the risk for healthy people to go on and develop first-time heart disease and stroke.”

Thank you for the highlighting and the source.
One question still remains unanswered.
Preamble
I am aware that it is necessary to avoid taking omega-3 supplements because they are easily altered, even if protected (…) and then thus contribute to the alteration of the oxidized membranes, especially when the support of tocopherols is absent (clearly insufficient via food). I take 500 IU from a 2x/week mix (Gamma E Complex, Now Foods). I read that the intake of vitamin E can saturate fat acids with long chains. (I didn’t find the source back, and this requires confirmation).
20 mg Vit for 10 gr of AGPI are required.
=>Ratio vitamin E / fatty acid in mg / g: 0.3/mono-; 2/di-; 3/tri-; 4/tetra-; 5/penta-; 6/hexaenoic fatty acid. (1-4)

Deduction: 10 gr omega-6 (ALA) needs 2 mg x 10 = 20 mg vit E.

Situation
The person regularly consumes less than 10 gr of PUFA per day, including 1.5 gr of ALA. He / I aim at 6 gr LA and 0.5 to 1 gr of omega-3. He also takes 0.2 gr from Vit C per day, 100 mcg Se 2x/ week. 2x/ week 500 UI of Toco (5) This person suffers from recurrent latent inflammation (backpain). He was doing a rotating with salicine, curcumin and Celadrin, for more than 15 years, without really taking a break, except when he was doing a water fast. (Not fine for the CYP450 evacuation pathway). But since this person did a treatment with vitamin B6 (100 mg PLP) (B1 B2 B3 B6 + TMG, according to a protocol and with pause), the pain manifests itself very rarely. B6 is also anti-inflammatory and moderates the immune response.
Question
Knowing that it would be appropriate to avoid adding a layer to the problem – oxidation of PUFA’s –, knowing that

the ratio and the amount AL / ALA is under control and at a moderate level (important), is it coherent / adequate to take half a tsp (2 gr) of oil rich in EPA, on a intermittent way,

well protected from oxidation (important).
Note that the protection time is only valid for 3 months, once the bottle is opened. After this period, I add an antioxidant (2 drops of Rosemary H.E.) (not vitamin E).
And once ingested, protection disappears. It must be renewed. (5)
I do this intermittently when I am between 6-10 gr of PUFA, without an adequate balance of omega-3 brought by food, only by food. I avoid oils, except olive oil and coconut. Omega-6 often comes from breakfast (Jordan oats + pecan nuts) 3x/week, and snack (wheat cake 2 x 24 gr or a Brownie 30 g). Note that there is an adequate SFA contribution at breakfast (Coco).
Sources et Références :

1. Efficacy of vitamin E in reducing oxidation of pufa

If 10 gr PUFA (1.5 W3 LA and 8.5 gr W6 ALA): (1.5 x 3) + (8.5 x 2) = 18.5 mg Vit E
Useful info:

• Mono-unsaturated fatty acid: Oleic acid. (Omega-9 = 9 Carbon atoms) 18:1 (9), n-9
• Di-unsaturated fatty acid: Linoleic acid (LA / Omega-6). 18:2 (9,12), n-6 (2 doubles liaisons en n9 et n12 sur la chaine carbonée).
• Tri-unsaturated fatty acids: Linolenic acid (ALA) (Omega-3). 18:3 (9,12,15), n-3 (3 doubles liaisons en n9, n12 et n15)
• Tetra-unsaturated fatty acids: Arachidonic acid (AA). 20:4 (5,8,11,14), n-6 (4 doubles liaisons)
• Penta-unsaturated fatty acids: Eicosapentaenoic acid (EPA). 20:5 (5,8,11,14,17), n-3 (5 doubles liaisons)
• Hexa-unsaturated fatty acids: Cervonic acid (or docosahexaenoic acid). 22:6 (4,7,10,13,16,19), n-3
  Note: Cervonic acid depends on consumption of omega 3 essential fatty acids (e.g., ALA or EPA), but the conversion process is inefficient. From fish oils.
  Sources and references:

1. To be reminded 1:
   “In declaring EPA and DHA to be safe, the FDA neglected to evaluate their antithyroid, immunosuppressive, lipid peroxidative (Song et al., 2000), light sensitizing, and antimitochondrial effects, their depression of glucose oxidation (Delarue et al., 2003), and their contribution to metastatic cancer (Klieveri, et al., 2000), lipofuscinosis and liver damage, among other problems.”
   From “The great fish oil experiment”. Ray Peat PhD. 2007
   http://raypeat.com/articles/articles/fishoil.shtml
   *) To be reminded 2
   Saturated Fat Protects Against Oxidation of Cholesterol Whereas Omega-6 Promotes It
   When cholesterol is bound to saturated fat, it is protected from oxidation, which lowers your risk for cardiovascular disease, and when it is bound to linoleic acid, the cholesterol is susceptible to oxidation, thereby raising your risk.
   The amount of linoleic acid contained in LDL can be seen as the true 'culprit' that initiates the process of oxidized LDL formation as it is the linoleic acid that is highly susceptible to oxidation.
   Dietary linoleic acid, especially when consumed from refined omega-6 vegetable oils, gets incorporated into all blood lipoproteins (such as LDL, VLDL and HDL) increasing the susceptibility of all lipoproteins to oxidize and hence increases cardiovascular risk." 16
2. Vitamin E function and requirements in relation to PUFA
   Daniel Raederstorff et al. Br J Nutr. 2015. doi: 10.1017/S000711451500272X
   =>## 20 mg Vit E for 10 gr PUFA
   *) The antioxidant function of vitamin E has been proven to be essential for preventing the oxidation of polyunsaturated fatty acids (PUFA) intake in men. PubMed 2000, E E Valk, G Hornstra – DOI: 10.1024/0300-9831.70.2.31
3. Vitamin E, Antioxidant and Nothing More
   Maret G. Traber and Jeffrey Atkinson. 2007 doi: 10.1016/j.freeradbiomed.2007.03.024
   The differences in potency of α-tocopherol versus other tocols in vivo is due to hepatic discrimination favoring α-tocopherol, as well as the preferential metabolism of non-α-tocopherol forms.
   Excerpt:
   Of the four tocopherols and four tocotrienols (designated as α-, β-, γ-, and δ-) found in food, only α-tocopherol meets human vitamin E requirements [15]. Despite the fact that all of these vitamin Es have similar antioxidant functions (rate constants for H-atom donation within an order of magnitude (Table)), non-α-tocopherols are poorly recognized by the hepatic α-tocopherol transfer protein (α-TTP) [16].
4. Quantitative Consideration of the Effect of Polyunsaturated Fatty Acid Content of the Diet Upon the Requirements for Vitamin E
   https://doi.org/10.1093/ajcn/13.6.385 1963
   Diets with E:PUFA ratios above 0.6 are predicted generally to protect against vitamin E deficiency, but diets with ratios lower than 0.6 are expected to have a depleting effect.
5. Synergy effect with vitamin E

“Vitamin C regenerates vitamin E and vitamin E protects β-carotene, helped in this by polyphenols. In the event of β-carotene supplementation (not advised: only 5-10 mg from food, note's editor), vitamin C regenerates vitamin E and β-carotene, and β-carotene seems to protect vitamin E without really explaining this phenomenon "(1)

Savings effect
Vitamin E is not just a vitamin. Vitamin C makes it possible to recycle oxidized vitamin E and thus prolong its lifespan. The same goes with glutathione which is thus saved for other more useful functions (detox). Glutathion is our antioxidant master. Vitamin E protects against the deleterious effects of polyunsaturated fatty acids when the latter are in excess. And it is quickly done!

1. John Libbey Eurotext - Anti-oxydants d’origine alimentaire : diversité, modes d’action anti-oxydante, interactions. Auteur : Claude Louis Léger.

@pittybitty said in What helps improve executive function?:

I've generally been fine in regards to energy since supplementing B vitamins, but the low executive function remains.

Give details, please, because it's not with a B-50 multi you're going to have a game changer.
You need to read these two links to understand why you lack B6 if you're inflamed or under-immune. Sure with dysbiosis.
And to understand why you need more B1 thiamine (not HCl) if you eat carbs like most people.

Potential roles of Vit B6 in inflammation and immunity.

Preventive role of B6 against chronic diseases & downregulation of the inflammatory mediators
https://mirzoune-ciboulette.forumactif.org/t2034-english-corner-potential-roles-of-vit-b6-in-inflammation-and-immunity#29633
Main ideas
• Preventive role of B6 against chronic diseases. Several diseases are mediated, at least in part, by lower inflammation, possibly through modulation of several kinases. (1)
• Vit B6 deficiency is associated with lower immune function and higher susceptibility to viral infection. (2) Megadoses do not produce additional benefits after repletion. (3-4) But elderly should benefit from cyclic supplement (with pauses and moderate amounts, aka 50 mg pyridoxamine).
• Plasma PLP levels were inversely correlated with systemic inflammation markers such as CRP. (5) Vitamin B6 supplementation suppressed IL-6 and increased total lymphocytes in patients with chronic conditions. (6)
• Vitamin B6 supplementation improved immune function in both human and animal studies. (7-8) It improves the immune response, causing increased antibody production, and enhances communicative interactions between cytokines and chemokines. (9-11)
• The authors of this study (0) assume that vitamin B6 is possible to suppress hyperinflammation, at least in part, through NLRP3 inflammasome inhibition, limiting virus spread and cytokine storm. Together with the notion that NLRP3 inflammasome plays a central role in chronic diseases, including CVD, diabetes, and acute viral pneumonia (12–14), the anti-inflammasome effect of vitamin B6 suggest its therapeutic role in reducing the severity of COVID-19 and its complications.
• Studies indicate that B6-vitamers can reduce superoxide radical and lipid peroxide levels induced by H2O2 in vascular endothelial cells (15). Too much sulfites (H2O2) exhaust B6 PLP.
• Pyridoxamine has anti-glycation activity and inhibits the formation of AGEs. (16)
• It was identified that high-dose vitamin B6 has a global anti-inflammatory effect on lipopolysaccharide-induced inflammation in monocyte/macrophage cells by downregulating the key broad-spectrum inflammatory mediators. (17-18)
Sources and References (in English, on the link, my forum).

See too:
English Corner – Vit B6: How much is too much?
Main ideas

• Too much of a good thing is bad.

Especially bad for neuro-sensitive people.

• Vitamin B6 is well documented for its role as a modulator of steroid hormones.
• No problem with food intake if not supplemented.
• Maximum RDA target is 25 mg B6. But update RDA is given at 6-12 mg.
• There are 6 vitamers and a way-out form through the urine.
• If we want a pharmacological effect, we have to take into account the form of the vitamers.
• The active form is B6 PLP.

And for B1 thiamin
*) ## Thiamine Deficiency - A Potential Cause of SIBO and other Gut Dysfunction?
https://mirzoune-ciboulette.forumactif.org/t1896-vit-b1-deficience-desordre-intestinal
Version complète plus complète sur ce site (Vaut le détour) : Elliot Overton – Nutrition and Functional Medicine
https://www.eonutrition.co.uk/post/thiamine-deficiency-a-major-cause-of-sibo – 01/2019
*) ## Thiamine and the Microbiome – Dr. Lonsdale
https://www.hormonesmatter.com/thiamine-microbiome/ 03/23
Excerpt:
The acquisition / bioavailability of thiamine is not only essential to the physiology of our organism and our good physical and mental condition, but thiamine is a cofactor for certain intestinal bacteria that change behavior depending on the variable availability of B1 .

@wester130 said in Natural antibiotic - Allicin, Neem and Oregano Oil,:

Would this work for SIBO?

Not enough.
As said by Kviron, we need to deal with a better metabolism or the problem won't disappear, and even worsens. You're going to kill some / a lot of bacteria with these options but not all the bacteria. The strongest ones will remain and overgrowth.
You must first get informed on how dealing with LPS when killing some bacteria (how to manage a saturated liver). Need to know how to avoid stagnation of starch in the second part of the colon (See MMC and SIBO / SIFO).
Afterwards you need to help thyroid for the right amount of energy with adapted nutrients.
And last but not the ultimate you have to balance the communication between the brain and the stomach (commensal bacteria).

Excerpt:
The lower regions of the brain responsible for coordinating the autonomic nervous system are particularly vulnerable to a deficiency of thiamine. Consequently, the metabolic derangement in these brain regions caused by deficiency produces dysfunctional autonomic outputs and misfiring, which goes on to exert detrimental effects on every bodily system – including the gastrointestinal organs.
However, the severe gut dysfunction in this context is not only caused by faulty central mechanisms in the brain, but also by tissue specific changes which occur when cells lack thiamine. The primary neurotransmitter utilized by the vagus nerve is acetylcholine. Enteric neurons also use acetylcholine to initiate peristaltic contractions necessary for proper gut motility. Thiamine is necessary for the synthesis of acetylcholine and low levels produce an acetylcholine deficit, which leads to reduced vagal tone and impaired motility in the stomach and small intestine.
In the stomach, thiamine deficiency inhibits the release of hydrochloric acid from gastric cells and leads to hypochlorydria (low stomach acid). The rate of gastric motility and emptying also grinds down to a halt, producing delayed emptying, upper GI bloating, GERD/reflux and nausea. This also reduces one’s ability to digest proteins. Due to its low pH, gastric acid is also a potent antimicrobial agent against acid-sensitive microorganisms. Hypochlorydria is considered a key risk factor for the development of bacterial overgrowth.
Source:
Dr Costantini SIBO and Thiamine Deficiency
Dr Costantini and bacterial overgrowth
SIBO, IBS, and Constipation: Unrecognized Thiamine Deficiency? – June 2020
https://www.hormonesmatter.com/sibo-ibs-constipation-thiamine-deficiency/

PS: You'll probably need to optimize bile and chlorhidric acid to optimize meat digestion if the digestion takes to long.
Bile & SIBO (in French, but with links in English)
Optimiser la bile & fluidifier le transit en cas de SIBO
https://mirzoune-ciboulette.forumactif.org/t2005-impact-de-la-bile-sur-le-microbiote-et-le-transit#29365
La prolifération bactérienne est fréquemment rencontrée chez les personnes qui souffrent de colopathie (IBS).

Here is an article of RP to understand why too much of a good thing can be bad, especially when substitution drugs are used (SSRI)
Serotonin, depression, and aggression: The problem of brain energy.
Ray PEAT
=> Excess serotonin is deleterious (nerve damage and mitochondrial respiration). Too much of a good thing is bad, especially if we want to play the role of the alchemist in the brain!
Excerpt 1
Anyone who has been reading the mass media and watching television in recent decades is familiar with the use of tryptophan as a tranquilizer.
Tryptophan is easily converted to serotonin and melatonin in the body, and those substances are believed to be responsible for its sedative, sleep inducing, or tranquilizing effects (Hebenstreit, et al.; Allikmets & Zharkovskii(; Shelekhov & Val'dman; Winokur, et al.). The most popular kind of “antidepressant,” the “serotonin reuptake inhibitor,” is said to act by increasing the action of serotonin in the brain. Many people have read articles in popular science magazines explaining that a deficiency of serotonin can cause depression, suicide, and aggression. Estrogen is often said to achieve some of its “wonderful” effects by increasing the effects of serotonin. (…)
Excerpt 2
Serotonin research is relatively new, but it rivals estrogen research for the level of incompetence and apparent fraudulent intent that can be found in professional publications.
This is partly because of the involvement of the drug industry, but the U.S. government also played a role in setting a pattern of confused and perverse interpretation of serotonin physiology, by its policy of denigrating and incriminating LSD, a powerful serotonin (approximate) antagonist, by any means possible, for example claiming that it causes genetic damage and provokes homicidal or suicidal violence. The issue of genetic damage was already disproved in the 1960s, but this was never publicly acknowledged by the National Institutes of Mental Health or other government agency. The government's irresponsible actions helped to create the drug culture, in which health warnings about drugs were widely disregarded, because the government had been caught in blatant fraud. In more recent years, government warnings about tryptophan supplements have been widely dismissed, because the government has so often lied. Even when the public health agencies try to do something right, they fail, because they have done so much wrong.
Excerpt 3
SSRI
The “serotonin reuptake inhibitors” are called the “third generation” of antidepressants.
Excerpt 4
To begin to understand serotonin, it's necessary to step back from the culture of neurotransmitters, and to look at the larger biological picture.
Serotonin and estrogen have many systematically interrelated functions, and women are much more likely to suffer from depression than men are.
Serotonin and histamine are increased by estrogen, and their activation mimics the effects of estrogen. Serotonin is closely involved in mood disorders, but also in a great variety of other problems that affect women much more frequently than men. These are probably primarily energy disorders, relating to cellular respiration and thyroid function. Liver disease and brain disease, e.g., Alzheimer's disease, are both much more common in women than in men, and serotonin and estrogen strongly affect the energetic processes in these organs. Liver disease can increase the brain's exposure to serotonin, ammonia, and histamine. It isn't just a coincidence that these three amines occur together and are neurotoxic; they are all stress-related substances, with natural roles in signaling and regulation.
There are good reasons for thinking that serotonin contributes to the nerve damage seen in multiple sclerosis and Alzheimer's disease. (…)
Excerpt 5
The “serotonin reuptake inhibitors” “are presumed” to have the same effect on the brain that they have on blood platelets. They inhibit the ability of platelets to retain and concentrate serotonin, allowing it to stay in the plasma. This uptake-inhibited condition is a model of the platelet behavior seen in multiple sclerosis and Alzheimer's disease.
Serotonin and its derivative, melatonin, are both involved in the biology of torpor and hibernation. Serotonin inhibits mitochondrial respiration.
Excitoxic death of nerve cells involves both the limitation of energy production, and increased cellular activation. Serotonin has both of these actions.
Serotonin activates glycolysis, forming lactic acid. Excess lactic acid tends to decrease efficient energy production by interfering with mitochondrial respiration.
Excerpt 6

Serotonin, like histamine, has its proper physiological functions, but it is a mediator of stress that has to be systematically balanced by the systems that support high energy respiratory metabolism.

The use of supplements of tryptophan, hydroxytryptophan, or of the serotonin promoting antidepressant drugs, seems to be biologically inappropriate.

Pittybitty said:
“The ability to work on a task that's not very interesting but still needs to be done.”
“So what I am wondering now, is there an non-prescription alternative to medication?”
=> Hi
I’ve written an article on serotonin, with “scientific links”, in French.
Is Serotonin a booster or a downer?
Here are two excerpts. If you want more, say it. And I‘ll give a link (translator needed except for the sources).
Excerpt 1
Is serotonin a booster or a downer?

Serotonin is a neurotransmitter of the central nervous system (CNS) secreted by a group of neurons called serotonergic neurons. Serotonin is one of the monoamines which are particularly involved in the regulation of vigilance and mood states. It is often seen that people of unstable, depressed mood are deficient in terms of hormonal secretion, with an impact on emotions, appetite, sleep, transient aggressiveness, etc.

Serotonin fulfills many other functions of metabolism, such as thermoregulation (extremity of cold limbs), pain control (anti-inflammatory), eating behavior (satiety), sexual desire, memory ... (1)
What effect can serotonin have on humans?
In addition to these biological functions, the effects of serotonin on our mind are not to be taken lightly (regulation of emotions), in more sensitive or more fragile people. Antidepressants are then often prescribed to rebalance the serotonin level. But we will discuss these selective serotonin reuptake in the brain (SSRI). It’s not really timely! It would be better to learn about light therapy and aid to compensate for inadequacies or overflows.
Is serotonin a booster or a downer (depressed)?
Role on depression and dopaminergic response
“By increasing extracellular serotonin, SSRIs disrupt energy homeostasis and often worsen symptoms during acute treatment. The science behind many anti-depressant medications appears to be backwards.” (3)
…
Excerpt 2
Useful nutrients
To rebalance the serotonergic function, it is necessary to associate:

• Vitamin B6 which participates in the synthesis of serotonin (very progressively, and rather P5P, with recovery staples) (…);
• Vitamin B3 (niacinamide, not niacin) which promotes the cerebral metabolism of tryptophan to depending on its liver metabolism (manufactured via the liver);
• magnesium to reduce stress, and which also has an anti-retention of water; NB1: A MG and B6 intake will therefore be welcome with the sweet snack of 5 p.m. Parenthesis: We often advise to eat a banana, a square of chocolate or some bursts of coconut, to the snack of 16-17h because these foods are naturally rich in tryptophan, the precursor of serotonin. Ok, but let's try to understand the process.
  …
  Note:
  95 % of serotonin (from the body) is produced in the intestine (5) The biosynthesis of serotonin is carried out in neurons or enterochromaffin cells. It is made from tryptophan, an amino acid that is brought to the brain by blood circulation among others. The tryptophan is absorbed by neurons thanks to a non -selective membrane carrier.
  To be continued, if desired.

Hi,
It's advised to begin slowly with thiamin.
Several processes are stimulated.
The brain is going to try to adapt the stimulus response, with more or less success (adaption time needed).
Wait before doing it again.
Take now magnésium bisglycinate (one scope = 2-3 gr) and potassium citrate powder (one scope 2 ml = 1.3 gr K).
And do it again with maximum 50 mg thiamin HCL (cut the gel into 2 pieces). With a meal.
NB: Too much HCL is toxic. Adapt the posology to needs.
I can give you a link if you want to go deeper in the comprehension of the mechanism.
Or go and watch Overton's videos.

@bowser said in Milk/protein digestion:

Although I still need to get protein and calcium and I want to use milk for that but every time I even try small amounts I get bad bacterial reactions and temps go down. Any suggestions?

Hi,
Most people loose the capacity to digest lactose (lactose is half glucose and half galactose).
When an individual consumes more lactose than what the enzyme lactase can digest, the non-digested lactose molecules remain in the intestine, attract water molecules and then cause gastrointestinal discomfort such as: bloating; abdominal pain; diarrhea.

And you don't need milk to get sufficient calcium. Ca from milk is only absorbed +/ 30%. 66 % from broccoli.
Have a look at oat to get the right amount of fiber and Ca at breakfast. I use Jordan's oat with hazelnut milk, 5 half pecan nuts and 1 tbsp raisins (organic because without sulfites). Adapt the ingredients to your tolerance.
If you balance with phosphorus and Ca, Gouda cheese is interesting. Few lactose in hard cheese.
I take 1/4 càc of calcium citrate powder when there is no sufficient Ca (650 - 850 mg Ca ) (no need for 1200 mg !) It also depends on the acido-basic balance. Enough potassium from fruits and vegetables.
What about your vitamin K2, in order to assimilate Ca?
Mind the fruits if dysbiosis. When stabilized, eat your fibers at first. 20-30' time for digestion.

Right with what has been said.
But you need to optimize the context:

• 30 gr fibers, functional MMC and gut motility.
  MMC= Motor Migrating Complex. I can develop / explain if wanted.
• Some useful nutrients for the communication between the brain and the intestines, through the vagus nerve.
  Thiamine as cofactor for autonomic nervous system
  When cells lack thiamine (B1) the lower regions of the brain – responsible for the coordination of the autonomic nervous system – there are metabolic derangements in the brain susceptible to produce dysfunctional autonomic outputs and misfiring, which goes on to exert detrimental effects on every bodily system – including the gastrointestinal organs.
  Thiamine is one of them.
• Some useful nutrients to feed gut bacteria. Make a search with “Biosynthesis of Vitamins by Probiotic Bacteria”. Or I can give you a link.
  Hope it can help.

When I say apart, it means you take coffee apart from digestion.
Most Vitamins B mut be taken with food.

@pittybitty said in What Vitamin B cofactors should I supplement?:

Is there anything I should add? I heard supplementing Thiamin causes Magnesium depletion, is there any other cofactors I should be aware of?

Hi,
You need enough sodium and particularly high level of potassium.
I take potassium citrate (oxalate prevention).
Shaker at breakfast and midday.
I won't take Vit B with coffee (diuretic) but appart from digestion. You lose +/ 0.5 gr salt (urinary excretion). + reabsorption difficult if too high in caffeine.
Do it according to taste (needs).
400 mcg folic acid is not the optimal form when taking high dose B9. However it's the maximum tolerated. Impact on B12 possible. Upper limit advised is often 1 000 mcg B9 but that's too high. 400 mcg is the advised limit.
doi: 10.1093/advances/nmab106
But as you take the complex every other day, it's more or less OK with your choice. Half-life must be taken into account. After one week, I would rather take the complex 2x/wk. that what I do,
For other readers:
Get informed on too high B6 with Pyridoxine HCL (PNP) Here, it's ok with 50 mg.
I can give a link if wanted.

@Mostlylurking
Thanks for your input. I really appreciate the comments. It emphasizes very well the efficacy / the value of HDT (high physiological dose).
I’d like to put this point into excerpt:
*) Why to give HDT?

When giving supra-physiological doses of thiamin to the cells, enzymes come back to normal operating state. (1)

=> We aim to increase the exchange through passive and active ways. The active way is made through enzyme transporters. The passive way is through cell membranes, if there aren’t too many blockers (from oxidative stress and chronic low-grade inflammation e.g.).
We know that the traditional way of transport of B1 TPP (from food) is through gastrointestinal phosphatases, before reaching blood flood. This B1 was thought to be only a water-soluble vitamin. It’s not. TPP can also be transported across cell membranes (2) but likely less well absorbed than benfotiamine or TTFD.
TPP = thiamine pyrophosphate.
*) Why and when nutritional intake is not sufficient.
If we read the conventional recommendations from authorities there is only a problem for 6% of the US population. (3) That’s what the blood tests mention. Right but what about your optimal energy level or your brain functioning? See here the difference of appreciation: an impaired metabolism with a metabolic disorder of thyroid or glycemia if left untreated (not perceived before it’s too late because the Gauss’s curve has said so). Traditional medicine sees the failure but doesn’t always / usually anticipate the problems from slow carburation. That’s just one example.
Gauss’s curve

The Gauss's curve analogy here emphasizes the concept of the "tail end" of the curve, where about 5% of cases fall outside the normal range. In this context, it suggests that there's a small percentage of cases where the metabolic disorder isn't perceived until it's too late. ## Traditional medicine tends to focus on the majority of cases within the normal range and may overlook or underestimate the significance of these outliers.
So, while traditional medicine might not see a problem because the majority of cases appear normal, it fails to anticipate the issues that arise from the small percentage of cases where metabolic disorders aren't detected early. This leads to the problem being left untreated, as it's not recognized until it's already advanced.
In summary, the Gauss's curve illustrates how the small percentage of cases falling outside the normal range can be overlooked, leading to the problem being untreated until it reaches a critical stage.
Metabolic Block
Are you exposed to “stress” factors that block your assimilation for the brain? As already seen, “thiamine (vitamin B1) is critical for the metabolism of food into cellular energy or ATP. Without sufficient thiamine, cellular energy wanes, and with it, the capacity to maintain the energy to function declines. Chronic, unrelenting fatigue is a common characteristic of insufficient thiamine. At its root, fatigue is the physical manifestation of poor energy metabolism”. (4)

Your appropriate blood test is then not going to explain anything.

Here are some case reports mentioning the insufficiency of the DRI (Daily Recommended Intake).
Diabetes
The proportion of people with type 1 or type 2 diabetes who have poor thiamin status based on erythrocyte transketolase activity ranges from 17% to 79% in studies conducted to date [40]. In a study of 76 consecutive patients with type 1 or type 2 diabetes, for example, 8% had mild thiamin deficiency and 32% had moderate deficiency based on assays of the transketolase enzyme [33].
Heart failures
The rates of poor thiamin status in patients with heart failure have ranged in studies from 21% to 98% [47]. Explanations for this association include older age, comorbidities, insufficient dietary intake, treatment with diuretics, and frequent hospitalizations [48].
The authors of one study reported that 33% of 100 patients with chronic heart failure had thiamin deficiency compared to 12% of 50 healthy volunteers [49]. Rates of deficiency were even higher when the investigators excluded those who used thiamin supplements.
Alzheimer’s disease
Thiamin deficiency produces oxidative stress in neurons, death of neurons, loss of memory, plaque formation, and changes in glucose metabolism—all markers of Alzheimer’s disease. Autopsy studies have shown that transketolase and other thiamin-dependent enzymes have decreased activity in the brains of people with Alzheimer’s disease [52,53].
Few studies have assessed the prevalence of thiamin deficiency in people with Alzheimer’s disease. One of these studies found that 13% of 150 patients with cognitive impairment and acute-onset behavioral disturbances were considered thiamin deficient based on plasma levels [26].
Note: Analysis based on plasma level gives only indication on short term. And not what is burned or blocked further in the process of assimilation.
Maintenance and Performance of the Brain
As already seen, thiamine plays a key role in the maintenance of brain function: Thiamine diphosphate is a cofactor for several enzymes involved in glucose metabolism whereas thiamine triphosphate has distinct properties at the neuronal membrane. (5) We need different forms of B1 to optimize different functions, and particularly to reach effects onto mitochondrial respiration.
Sources and References

1. Elliot Overton
2. How is B1 from food assimilated?
   DOI: 10.1534/genetics.104.028605
   Dietary thiamine (vitamin B1) consists mainly of thiamine pyrophosphate (TPP), which is transformed into thiamine by gastrointestinal phosphatases before absorption. It was believed that TPP itself cannot be transported across plasma membranes in significant amounts, which forms TPP from thiamine at the expense of ATP inside cells. (…) These observations indicate that, in contrast to expectation from previous evidence, TPP can be transported across cell membranes. We also find that thiamine supplementation partially rescues the phenotype of partial loss-of-function mutants of the Na/K ATPase, providing genetic evidence that thiamine absorption, and/or redistribution from the absorbing cells, requires the full activity of this enzyme.
   => Comment Luch: We need the transketolase enzyme to absorb well this type of B1 (TPP from food). To fully absorb the benefits of TPP, passive transport through membranes is required.
3. The average daily thiamin intake from foods and supplements in adults age 20 and older is 4.89 mg. An analysis of data from the 2003–2006 National Health and Nutrition Examination Survey showed that only 6% of the U.S. population has a usual intake below the EAR.
   https://ods.od.nih.gov/factsheets/Thiamin-HealthProfessional/#h6
   The World Health Organization recommends daily oral doses of 10 mg thiamin for a week, followed by 3–5 mg/daily for at least 6 weeks, to treat mild thiamin deficiency.
4. Dr. Chandler Marrs talking about Thiamin. April 2022
   Introduction to a video, talking with Scott Scott Forsgren, FDN-P.
   https://www.hormonesmatter.com/talking-about-thiamine/
5. Thiamine diphosphate is a cofactor for several enzymes involved in glucose metabolism whereas thiamine triphosphate has distinct properties at the neuronal membrane
   https://mirzoune-ciboulette.forumactif.org/t2045-english-corner-anti-stress-neuro-protective-effects-of-thiamine-b1#29713

Remind: 3 pillars of thiamine repletion

1. Identify which vitamin B1 your body needs / is accepted by your metabolism (transport capacity, genetic deficiency).
2. At least these cofactors are needed: magnesium, potassium and sodium (in proportions, for the two last ones).
3. Some vitamins handles as B-vitamin cofactors. Interaction with other B-vitamins.
   Figure: circle with Vitamins B interaction (B1 B2 B6 Biotin, underlined in yellow)
   

Hi,
I said I would come back and give a comment. I did some research and compile what I’ve understood, so far. An input would be appreciated, if you feel so and have time to deal with. Too many people struggle with so-called auto-immune pathologies when we don’t understood the etiology entirely. Partly true but …
This information could give an alternative, possibly the opportunity to perceive an improvement, if the tissues are not too destroyed. We won’t recuperate the lost synapses but as we only use 10 % of our brain, we are able to bypass and create new connections.

Anti-Stress & Neuro-Protective Effects of Thiamine (B1)

Mitochondrial Energy Uploaded thanks to Optimized Enzyme Communication

Key points
• Thiamine (B1) has also neuro-protective effects: Brain & Digestive System.
• B1 must be seen as the fuel for a power plant the bioavailability of which is dependent on enzyme functionality.
• Oxidative and chronic low-grade inflammation induce a metabolic block.
• When giving supra-physiological doses of thiamin to the cells, enzymes come back to normal operating state.
• Universal anti-stress properties of thiamine.
• Impact on mitochondrial respiration: link with ATP production.
• The role of thiamine insufficiency in lower brain dysfunction.
• Connection between the brain, the digestive system and the vagus nerve: Dysautonomia and adaptation to the stress environment when fuel is re-loaded.
• Understanding nutritional deficiencies & functional insufficiencies / dependencies.
Cases reports on pathologies: Energy, SIBO, diabetes, fibromyalgia, Parkinson’s, CVD, thyroiditis, multiple sclerosis, etc.

Full post on this link, with explanations, figures, studies links and case reports if you want details and see how to manage in practice.
https://mirzoune-ciboulette.forumactif.org/t2045-english-corner-anti-stress-neuro-protective-effects-of-thiamine-b1#29712

Info continuation
Main points in practice

1. Support you own endogenous production of DAO with useful nutrients. ## Be sure to get enough of vitamin C B6 (P5P) and coper.
   Pay attention:

• Not a vitamin B complex. 50 mg B6 is OK. B6 must be co-enzymed (P5P), without additive preferably.
  • Swanson, P-5-P-pyridoxal-5-phosphate, 20 mg, 60 capsules. 3.51 € iherb.com, 0.18 €/gel.
  =>Advised choice for dosage if neuronal pathology (hypersensitivity). 1x/d.
  Pay attention: Too much of a good thing is bad. ## There is a threshold not to overload with B6 PLP, depending on your underlying degree of low grade inflammation and neuro-pathologies. pauses are required with PLP (effective form).
  • Thorne, Pyridoxal 5'-phosphate, 180 capsules. 33.8 mg. With dioxide Si. 47.28 € - 10% by iherb..com, 0.263 €/gel.
  • Nutrabio 100 mg, 60 capsules. 14.72 €, 0.25 €/ gel. My choice because without excipient. 1x/ every other day (every two days).
• Chelated Coper (bisglycinate coper 10-15 mg, twice a day if suffering from dysbiosis).
• Vitamin C must be identified with CAS N° 50-81-7 (or with Specific Optical Rotation, between +20.5°~+21.5°) (without HM => certificate). Otherwise it’s half not assimilated (rubbish). Mine comes from Scotland, organic source (not from China). Labelled acid ascorbic quali-c (nutrimuscle.com 125 gr 22.95 €). Surfine powdered vitamin so that it dimots well, without residue.

• Magnesium bisglycinate (mind the origin: well diluted and taste) we lack Mg.

2. DAO enzyme. 1 000 000 units.
   I take NaturDAO 10-15’ before meal 3x/d. Gradually stop treatment (amazon.fr)
   I won’t eat liver more than once every 5 days. And from organic source or from poultry (young chicken).
3. Support your methylation: For example with betaïne HCL (Now Food, with pepsin) or with TMG supplement (Now Food, TMG 1000 mg or 2x 500 mg). I take TMG (tri-methyl-glycine) 2250 mg from Super Smart (with a 30 % discount). No need to be so high.
   NDLR: Chris Masterjohn has recommended TMG when taking B3 (niacin).
   What is the difference between betaine HCl and trimethylglycine?
   Betaine HCl has an acidic taste whereas anhydrous TMG ("anhydrous betaine") tastes sweet with a metallic aftertaste and is usually produced from sugar beets (as is betaine hydrochloride). Both are active as methyl donors, as 'betaine' is retained in both forms.
4. Mast cell control
   I take quercetin anhydride 500 mg (nutrixeal.com) once a day. With a meal because some fat is required. In cure. Or every other week (every two weeks).
   Mind some foods:
   We should not only worry about foods that contain large quantity histamine (H3 in the PDF list), but also foods that release histamine (L3 in the PDF list, in French) (L stands for liberation). For example, tuna is classified H3 (high contribution), the orange fruit is L3 (leads to a high reaction of histamine release).
5. Histamine Diet
   See PDF list.
   Useful info (in French)
   https://mirzoune-ciboulette.forumactif.org/t1745-traiter-lintolerance-a-lhistamine?highlight=histamine
   => How to deal with histamine intolerance + short list of food high in histamine.
   See beneath for an English source.
   L3 (power 3/3) (L stand for liberator => set free)
   Walnut, lemon (lime), orange, grapefruit, wine and balsamic vinegar, alcohol, iodine. Other examples on this link (list of incompatibility for histamine, in French):
   Noix, citron vert (lime), orange, pamplemousse, vinaigre de vin et balsamique, alcool, iode.
   Autres exemples sur ce lien (Liste d’incompatibilité à l’histamine) :
   https://www.mastzellaktivierung.info/downloads/foodlist/31_FoodList_FR_alphab_avecCat.pdf
   It is not because a food brings little histamine that he does not cause a release of histamine. So be careful not to be based only on a single info source. It is above all the accumulation that must be avoided, and be careful in more sensitive times, of course.
   Traduction : Ce n’est pas parce qu’un aliment apporte peu d’histamine qu’il n’entraine pas une libération d’histamine. Donc, attention à ne pas se baser seulement sur une seule source d’info. C’est surtout le cumul qu’il faut éviter, et faire attention en période plus sensible, évidemment.
6. Alcohol and other drugs
   Alcohol overburdens liver detox. There are many drugs with prohibited molecules.
   See link. I made a copy in a docx in order to make a search easily. By the way, I made 2 mistakes: curcumine and High dose thiamine (B1) before recovering. + pineapple (L2) in crisis.
   This group does extensive research on histamine and is quite reputable. They list Thiamine/B1 as being a liberator and DAO blocker with certain types of administration:
   *) Thiamin as histamin liberator and DAO inhibitor
   Sattler 1985 (PDF with reference on histamine active substance, in English)
   Sattler J, Hesterberg R, Lorenz W, Schmidt U, Crombach M, Stahlknecht CD.: "Inhibition of human and canine diamine oxidase by drugs used in an intensive care unit: relevance for clinical side effects?" Agents Actions. 1985 Apr;16(3-4):91-4.
   https://pubmed.ncbi.nlm.nih.gov/3925736
   (Liste unverträglicher Medikamente (DAO-Hemmer))
   *) Low histamine Diet Anit Tee factvsfitness.com (pdf with info I English)
   *) Liste de compatibilité alimentaire – Histamine
   Triée par ordre alphabétique, avec catégories.
   Communauté d'intérêts Suisse de l'intolérance à l'histamine (SIGHI) www.mastzellaktivierung.info | www.histaminintoleranz.ch => rubrique téléchargement / Liste détaillée de la compatibilité des aliments de base (rubrique : Régime alimentaire pour éliminer l'histamine > Téléchargement).
   Info en anglais / français / allemand.
   Liste PDF en français
   FoodList histamine, FR, alphabétique, avec catégories
   https://www.mastzellaktivierung.info/downloads/foodlist/31_FoodList_FR_alphab_avecCat.pdf
7. Fix the gut
   => Dysbiosis – Probiotics? – Strengthen gut walls – Target diet if intolerant gut

Sources and references
0. Useful Info

• Dr. Becky Campbell – Free Histamine Guide.
• https://lowhistamineeats.com/clear-histamine-naturally/
• Reversing Histamine Intolerance Takes More Than a Low-Histamine Diet
  https://caplanhealthinstitute.com/reversing-histamine-intolerance-takes-more-than-a-low-histamine-diet/
• https://drtaniadempsey.com/5-natural-antihistamines-to-combat-allergies/
  Sources and references

1. “Effect of dietary fatty acid and micronutrient intake/energy ratio on serum diamine oxidase activity in healthy women”
   https://pubmed.ncbi.nlm.nih.gov/28606572/
   Results: Serum DAO activity in both phases was positively correlated with intake of long-chain fatty acids, saturated fatty acids, and monounsaturated fatty acids (P < 0.05). Intake of phosphorus, calcium, zinc, magnesium, iron, and vitamin B12 during the luteal phase was positively correlated with serum DAO activity (P < 0.05).
2. “Nutrient-induced inflammation in the intestine – PMC –NCBI.”
   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520304/
   Understanding the relationship between nutrient absorption and intestinal inflammation is important. We need a better understanding of the interaction between enterocytes and the intestinal immune cells in nutrient absorption and the gut inflammatory responses.
3. The increased release of histamine and DAO is specific to fat feeding and is not shared by carbohydrate or protein feeding.
   Wollin A, Wang XL, Tso P. Nutrients regulate diamine oxidase release from intestinal mucosa. Am J Physiol. 1998;275:R969–R975. [PubMed] [Google Scholar]
4. Adopting a leaky gut protocol or a diet rich in anti-inflammatory foods and high in antioxidants, can be instrumental in addressing the root-problem.
   Improving gut health and taking DAO are pillars of histamine intolerance treatment.
   https://caplanhealthinstitute.com/reversing-histamine-intolerance-takes-more-than-a-low-histamine-diet/
   Useful nutrients include vitamins B6, copper, iron, magnesium, phosphorus, zinc, and vitamin C. (a,b) Each of these nutrients both support and modulate immune function for the better.
   a. Maintz L, Novak N. Histamine and histamine intolerance. Am J Clin Nutr. 2007;85(5):1185-1196. doi:10.1093/ajcn/85.5.1185
   b. Miyoshi M, Ueno M, Matsuo M, et al. Effect of dietary fatty acid and micronutrient intake/energy ratio on serum diamine oxidase activity in healthy women. Nutrition. 2017;39-40:67-70. doi:10.1016/j.nut.2017.03.004
5. Le syndrome d'activation des mastocytes et l'activation inappropriée des mastocytes
   Les symptômes proviennent principalement de la libération de médiateurs et comprennent un prurit, des bouffées de chaleur et une dyspepsie due à une hypersécrétion gastrique.
6. Mastocyte activation syndrome and inappropriate activation of mastocytes
   Symptoms come mainly from the release of mediators and include pruritus, hot flashes and dyspepsia due to gastric hypersecretion.

@Sugar said in What to do about histamine intolerance?:

What do you guys think can help me get back to normal?

Hi,
Some time will be needed to evacuate metabolites when taking High Dose Niacin.
Never above 20-25 mg B3 if not niacinamide.
When taking B3, we need B6. Not necessarily at the same time.
I would take a 50 B complex co-enymed 2x/wk. interaction.
Here is some info How I dealt with histamine intolerance due to overgrowth bacteria, flatulences and gas.
Histamine intolerance – Chris Masterjohn Lite.
The English corner: Fix the gut – 7 steps to cure histamine intolerance
https://mirzoune-ciboulette.forumactif.org/t2028-the-english-corner-fix-the-gut#29578
https://youtu.be/sv70d1OVXHs (copy the link and put in a search internet motor)
Excerpt (video of Chris Masterjohn, under-titled) (With benchmarks at the 7 stages)

1. Video 47’’: Support you own endogenous production of DAO,
   DAO is supposed to clear off all the histamine from food.
   DAO = de-amine oxidase = enzyme able to degrade produced histamine.
   Be sure to get enough of vitamin C B6 (P5P) and coper.
2. Video 1.48”: Supplement with DAO enzyme: kidney, liver worst, kidney supplement (= DAO supplement)
3. Video 2.49”: Support your methylation (=> e.g. with TMG supplement)
4. Video 3.37”: Mast cell control.
   Mind lack of Se and retinol (vit A).
   Mind inflammation (see medical doctor to handle the problem). Some molecules are prohibited (histamine producer and liberator).
5. Video 4.27”: Histamine from your diet
   Mind the most offended food: aged, fermented or preserved food.
   Examples of food high in histamine: semi- and hard cheese, canned anchovies, smoked fish, deli meat, curry, mustard, soy sauce, yeast, avocado, banana, dried food, dried nuts, lemon, mandarin, and pineapple.
   NDLR: These are only some most common examples, of food containing histamine (H). Some food cause the release (R) of histamine when they don't really contain it.
   If you eat these foods you can’t get rid of intolerance, you can’t get cured: you’re only managing the intolerance (the excessive reaction of mast cells).
   After healing, you may reintroduce some banned foods and see how you tolerate a slight amount of them.
6. Video 5.55’’: Alcohol and other drugs
   Alcohol and some drugs interfere with histamine clearance. A sweet spot of alcohol can be tolerated 3 times a week. Many medications are concerned. See listing.
7. Video 6.48’’: Fix the gut.
   If inflamed, there could be a poor production of DAO enzyme, a mast cell burning and a microbiome dysbiosis.
   To be continued on next post.

@mostlylurking
Thanks for developing. I appreciate.
I'm going to read further (links) and come back soon after when digested.
See you later.
Correcting Mast Cell Activation Syndrome - Histamine Intolerance - Mastocytosis - Biologix Center for Optimum Health
https://biologixcenter.com/allergies/correcting-mast-cell-activation-syndrome-histamine-intolerance-mastocytosis/
This group does extensive research on histamine and is quite reputable. They list Thiamine/B1 as being a liberator and DAO blocker with certain types of administration:
HIT > Therapy > Medicaments
https://www.histaminintoleranz.ch/en/therapy_medicaments.html#antihistamines
*1 => Thiamin as histamin liberator and DAO inhibitor
Sattler 1985 (PDF with reference on histamine active substance)
Sattler J, Hesterberg R, Lorenz W, Schmidt U, Crombach M, Stahlknecht CD.: "Inhibition of human and canine diamine oxidase by drugs used in an intensive care unit: relevance for clinical side effects?" Agents Actions. 1985 Apr;16(3-4):91-4.
https://pubmed.ncbi.nlm.nih.gov/3925736
(Liste unverträglicher Medikamente (DAO-Hemmer))
Büttiker (same PDF with reference on histamine active substance)
*) Lack of magnesium
Specific change of histamine metabolism in acute magnesium-deficient young rats. - PubMed - NCBI
*1 ## Incompatible medicaments
Histamine liberators
Many agents in medicaments (active substances as well as additives) have the negative effect that they cause mast cell degranulation which leads to release of histamine and other mast cell mediators. They have to be avoided where ever possible according to the agreement with your physician.
DAO-Inhibitors
Many agents in medicaments have the negative effect that they are diamine oxidase inhibitors or inhibitors of other histamine degrading enzymes. They have to be avoided where ever possible according to the agreement with your physician.
List of incompatible active substances in medicaments
This list needs to be completed. Please let us know your experiences with other substances.
Set in excerpt (LucH): Acetyl-cysteine (NAC), aspirin, many barbiturates, bile acid, codeine, gelatin (bone broth), NSAID, quinine, thiamin and tyramine.

@mostlylurking said in High-dose thiamine troubleshooting:

by supplementing enough thiamine so that my autonomic nervous system could function normally. "insufficient electrical contractile bowel movements" are insufficient because the autonomic nervous system is not sending the electrical impulses via the vagus nerve needed for peristalsis to happen. It's a communication problem between the brain and the intestine via the vagus nerve.

The reasoning is good. Thanks for developing.
Could you give details about your "protocol". The posology of thiamin: posology and duration, please. It could help other readers too. + interaction with B2, I suppose.
I had to stop high dose thiamin because of histamine.
Next post for details to come, after your answer, to avoid interference
Thanks for comprehension.

B1 / Thiamine Causing Histamine Issues

Hi,
The order in which you eat your food plays a huge role in the metabolic effect. Eating carbs last versus first is more beneficial in reducing insulin and glucose, which plays a big role in weight gain. To maximize weight loss, eat the carbs last. Dr Jason Fung reviews the studies showing this effect.
https://www.youtube.com/watch?v=o8TeVf6rR7k

Note that the first meal of the day has a huge impact on insulin secretion for the whole day.
Source : doi: 10.2337/dc15-0429
Shukla AP, leesbuRG, Thomas CE, Aronne IN. Food Order has a Significant Impact on Post-prandial Glucose Levels. The obesity society’s 2014 Annual Scientific Meeting. Diabetes care. 2015