@Serotoninskeptic
Thiamine is very important for depression.
https://hormonesmatter.com/depression-anxiety-chronically-hypoxic-brain/

Thiamine is required to clear serotonin from the brain.
Effect of thiamine deficiency on brain serotonin turnover

Magnesium is very important too:
Magnesium Status and Stress: The Vicious Circle Concept Revisited

@Anakin Everybody's different; it depends on a lot of variables; a big one is how much oxidative stress you're under. Dr. Chandler Marrs has some excellent videos where she talks about some of her patients. Some of them are taking as much as a gram + of pure TTFD.

Here's a video with Elliot Overton about mega doses.

I personally was unable to tolerate even a single capsule of TTFD because my glutathione level was very low. See here. But I could tolerate thiamine hcl in high doses with no problems. That's why I'm a fan of thiamine hcl. That said, my husband takes 200mgs of TTFD daily and has never had an issue with it.

Pure bulk thiamine hcl is pretty cheap stuff.

@Anakin said in Atypical facial neuralgia | Nerve pain:

@mostlylurking 100 mg, I bought a big bottle at Objective Nutrition and I'm going to finish it, I've been taking it for two months

And Im feelin OK with 100 mg no bad side effects or reaction I just have my horrible pain all the day

I want the pain to STOP because I love life I dont want be in pain 24 hours

You could try taking 2 a day instead of one. You could conceivably need more than that. Or (and) you could get some bulk powder thiamine hcl and try taking some of it also.

Did you get the pure TTFD or did you get that mix?

When I first started taking thiamine hcl, I tried taking 300-350mgs of it in water only, an hour after eating lunch. I was in a lot of pain and aspirin wasn't beginning to touch it. Within 45 minutes of taking the thiamine hcl, all of my pain disappeared, my brain fog lifted, and my body temperature went up a full degree to normal (98.6). So I drove to the grocery store and did the shopping for the first time in weeks.

@Anakin How much TTFD did you take? How long did you take it?

@Anakin said in Atypical facial neuralgia | Nerve pain:

@Sugarnotsnow said in Atypical facial neuralgia | Nerve pain:

@Anakin Maybe try aspirin. It works wonders for pain relief in my experience

@mostlylurking said in Atypical facial neuralgia | Nerve pain:

Facial neuralgia can be caused by thiamine deficiency
https://www.objectivenutrients.com/insights/thiamine-ttfd-nerve-damage-trigeminal-neuralgia-hearing-loss/

Years ago (1994), I experienced severe facial nerve pain when I was being chelated for heavy metals. EDTA IV chelation is known to deplete thiamine. I didn't know enough then to understand the reason for the pain, but thankfully my doctor did; he had me take 16 b-complex capsules daily for years (4 caps, 4 times a day); this equaled to 1600mgs of thiamine hcl daily.

My facial nerve pain (1994) resolved in about 7-10 days. During that time, the only thing that I found that helped with the pain was application of hot wet compresses.

Decades later, after I had stopped supplementing vitamins, I went through years of TMJ, bruxism, jaw pain. All this resolved a few years ago when I resumed taking high dose thiamine hcl.

My own health issues require that I take high doses of thiamine hcl; I take 1 gram, two times a day. I'm living with high oxidative stress that is caused by mercury toxicity. High oxidative stress depletes thiamine. The high dose thiamine resolves the high oxidative stress and has been tremendously helpful for multiple health issues.

Unfortunately I have tried thiamine ttfd and aspirin but I still have pain.

I couldn't tolerate TTFD myself, because my glutathione was low, due to my high oxidative stress that was caused by mercury toxicity. I take thiamine hcl instead, high dose. It has resolved a multitude of health issues for me. I no longer have TMJ/bruxism/neuralgia in my face. I also don't have digestive problems and allergies any more (among other things).

https://hormonesmatter.com/thiamine-deficiency-causes-problems/

@Anakin said in Atypical facial neuralgia | Nerve pain:

Does anyone know of any remedy, cure or at least a way to reduce the pain?

My ideas have been: pregnenolone, DHEA, emodin, androsterone, aspirin, vitamin D, glycine, B vitamins, L-tyrosine, lysine, olive leaf extract, niacinamide, theanine, agmatine, phospatidic acid, cyproheptadine and tianeptine.

Maybe rufinamide? Benadryl? Its dangerous block sodium channels?

Its good block calcium channels? Cypro do this.

Ive been prescribed eslicarbazepine but Im afraid to take because of all the side effects including increase serotonin in the brain.

Thank you very much,

Facial neuralgia can be caused by thiamine deficiency
https://www.objectivenutrients.com/insights/thiamine-ttfd-nerve-damage-trigeminal-neuralgia-hearing-loss/

Years ago (1994), I experienced severe facial nerve pain when I was being chelated for heavy metals. EDTA IV chelation is known to deplete thiamine. I didn't know enough then to understand the reason for the pain, but thankfully my doctor did; he had me take 16 b-complex capsules daily for years (4 caps, 4 times a day); this equaled to 1600mgs of thiamine hcl daily.

My facial nerve pain (1994) resolved in about 7-10 days. During that time, the only thing that I found that helped with the pain was application of hot wet compresses.

Decades later, after I had stopped supplementing vitamins, I went through years of TMJ, bruxism, jaw pain. All this resolved a few years ago when I resumed taking high dose thiamine hcl.

My own health issues require that I take high doses of thiamine hcl; I take 1 gram, two times a day. I'm living with high oxidative stress that is caused by mercury toxicity. High oxidative stress depletes thiamine. The high dose thiamine resolves the high oxidative stress and has been tremendously helpful for multiple health issues.

@CrumblingCookie I found an article that you might find of interest:
https://hormonesmatter.com/can-we-synthesize-oxythiamine-and-pyrithiamine-endogenously/

@the-MOUSE I think that the articles written by Dr.Lonsdale and Dr. Chandler Marrs about the gut microbiome are very good.

https://hormonesmatter.com/thiamine-microbiome/

https://hormonesmatter.com/quick-thoughts-bacterial-thiamine-synthesis-dysmotility-and-dysbiosis/

https://hormonesmatter.com/gastrointestinal-disease-thiamine/

@the-MOUSE Ray Peat liked Greek yogurt because it is strained so has most of the lactic acid removed. If the container develops liquid separated from the solid, just pour it off. The American yogurt has too much lactic acid in it.

@CrumblingCookie Thanks!

I wondered why Dr Costantini warned against taking oral thiamine hcl doses with "sour" liquids; now I know. Water only, never juices. Costantini also advised taking thiamine at least 30 minutes away from eating food. Perhaps this is because eating food would trigger the release of stomach acid? Makes sense to me.

The recommended dose amounts in the literature you cited seems very low to me (30-45mgs/day), probably because I've been reading about thiamine supplementation and cancer. Low doses are said to be pro-cancer.

The effect of thiamine supplementation on tumour proliferation. A metabolic control analysis study
"Thiamine supplementation in doses between 12.5 and 250 times the recommended dietary allowance (RDA) for mice were administered starting on day four of tumour inoculation. We observed a high stimulatory effect on tumour growth of 164% compared to controls at a thiamine dose of 25 times the RDA. This growth stimulatory effect was predicted on the basis of correction of the pre-existing level of thiamine deficiency (42%), as assayed by the cofactor/enzyme ratio. Interestingly, at very high overdoses of thiamine, approximately 2500 times the RDA, thiamine supplementation had the opposite effect and caused 10% inhibition of tumour growth. This effect was heightened, resulting in a 36% decrease, when thiamine supplementation was administered from the 7th day prior to tumour inoculation. Our results show that thiamine supplementation sufficient to correct existing thiamine deficiency stimulates tumour proliferation as predicted by MCA. The tumour inhibitory effect at high doses of thiamine is unexplained and merits further study. "

Linking vitamin B1 with cancer cell metabolism
"In 2001, Comin-Anduix et al. evaluated the effect of increasing thiamine supplementation in multiples of the RDI on an Ehrlich ascites tumor-mouse model [58]. Their findings indicated a statistically significant stimulatory effect of thiamine supplementation on tumor growth compared to non-supplemented controls. Moderate doses of 12.5 to 37.5 times the RDI had the greatest stimulatory effect, peaking at approximately 250% greater tumor cell proliferation with 25 times the RDI. Interestingly, at values above 75 times the RDI, no change was found in tumor cell proliferation, and a slight decrease was found at 2,500 times the RDI. This observation suggests that there is a specific range in which thiamine supports proliferation. "

RDI for adults: "The RDI of thiamine for adults 18 and older is 1.2 mg/d for men and 1.1 mg/d for women. "