@Mauritio
If high dosing thiamine, also watch out for magnesium issues, potassium (I rely on OJ), zinc, riboflavin (yes!).
Latest posts made by mostlylurking
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RE: Vitamin B6 supplement makes me feel great, why? Safe for long-term use?
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RE: High DHEA, Cortisol, Lactate, Prolactin, Progesteron but low PTH
@StreamOfWater said in High DHEA, Cortisol, Lactate, Prolactin, Progesteron but low PTH:
Hi, I just received (29, male) bloodwork results. Here they are:
DHEA: 30 nmol/l
Cortisol: 615 nmol/l
Lactate: 2.10 mmol/l
Prolactin: 21 μg/l
Progesterone: 3.3 nmol/l
PTH: 2.0 pmol/l
LDL Cholesterol: 3.90 mmol/l
TSH: 2.5I have been following Ray Peat's approach for 2 years, but was already eating low in PUFA and avoiding most processed foods for years. I mostly eat dark vegetables, potatoes, cheese, eggs, meat, honey, some citrus fruits, some seafood and drink a lot of milk. This is what I mostly eat in winter. In summer, definitely more carbs (fruits).
I had more blood markers tested, but the ones I mentioned are the most concerning.
I did not take any supplements for 2 months prior to the blood test.
What is the best course of action for me in this situation?
It would be helpful if you would please provide the test ranges in addition to the numbers of your own results.
Your TSH is high. A full thyroid panel including free T4, free T3, and reverse T3 would be helpful. The goal is to have a low PTH; it means your parathyroid is quiet and happy and not pumping out PTH.
Without the ranges for the lab tests, evaluation of your results is difficult if not possible. Look on your lab tests and see if you can find them.
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RE: Vitamin B6 supplement makes me feel great, why? Safe for long-term use?
@MasterPeatler you're welcome. BTW, I'm female, age 74.
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RE: Endotoxin Inflammation Stack
@Ismail said in Endotoxin Inflammation Stack:
@mostlylurking I wish I could get back the feeling I had when I used Elliot Overton’s Thiamega B1 supplement. I split the capsule into 4, and took after each meal I had, I felt such a sudden energy boost, like I could achieve anything.
I tried the next day, however it didn’t give me the same energy.
I can only surmise I may have “depleted” something whilst high dosing the B1, so I took it with a b-complex as well as magnesium. Still didn’t give the same energy boost.
Any idea what I may be missing? In terms of possible co-factors that help the uptake of B1? ThanksElliot Overton's Thiamax B1 is a TTFD product. I was unable to tolerate it because my glutathione level was very low due to my high oxidative stress level (caused by my mercury toxicity). TTFD uses glutathione to work so if you are deficient, it can make the situation worse. I learned from Elliot Overton that taking thiamine hcl does not lower glutathione and it can actually improve glutathione status. So I stuck with thiamine hcl and follow Dr. Costantini's protocol. My glutathione status normalized in about 4 months (blood testing). I still high dose thiamine hcl; I've still got the mercury problem, but I'm pretty much without negative symptoms now; actually, I'm fine. High dose thiamine hcl (+magnesium glycinate and other b vitamins) normalized my entire digestive tract. Even though my gut bacteria was severely damaged by the Bactrim antibiotic, things got sorted out pretty quickly once I attained my optimum dose of thiamine hcl per Dr. Costantini's Therapy info (based on body weight).
@herayclitus said in Endotoxin Inflammation Stack:
@mostlylurking Thanks for sharing this--I think it's definitely a leaky gut issue, as alcohol aggravates it worse than anything else. I have been taking thiamine HCl and gelatin as well. Magnesium tends to irritate my gut but I might try it again in a lower dose
Are you drinking alcohol? As long as you do that, you will have problems.
Wernicke Encephalopathy "Thiamine deficiency is characteristically associated with severe alcohol use disorder. Although Wernicke encephalopathy mostly affects people who have a thiamine deficiency due to chronic alcoholism, various other causes include severe malnutrition, hyperemesis gravidarum, prolonged parenteral nutrition, malignancies, immunodeficiency syndromes, liver disease, hyperthyroidism, and severe anorexia nervosa. Chronic alcohol consumption may cause thiamine deficiency due to impaired absorption of thiamine from the intestine...."
"A common inciting event that precipitates WE is an acute infection. Other triggers include prolonged carbohydrate or glucose loading in the presence of thiamine deficiency. In general, patients who receive glucose should also be administered thiamine at the same time."
-end paste-I've had Wernicke's encephalopathy (fall 2020). I was borderline thiamine deficient even though I was taking 100mgs of thiamine hcl daily and I don't drink alcohol. But my intake of orange juice and fruit was pretty high. And my oxidative stress level was high because of heavy metal toxins (mercury mainly) - high oxidative stress gobbles up thiamine. And then I took Bactrim antibiotic for a UTI. That's all it took; I nearly died. But then I read up about thiamine, found Dr. Costantini's website, implemented what I learned, and managed to pull myself back from the brink.
I found the information on Dr. Costantini's website most helpful. He treated Parkinson's Disease patients with high dose thiamine hcl. There is a connection between gut disbiosis and acquiring Parkinson's Disease. I had suffered with multiple gut disbiosis issues for many years: poor esophageal peristalsis, very low stomach acid, SIBO, leaky gut, constipation/diarrhea, almost universally reactive to foods and environmental toxins. I did not understand that there is a connection between gut disbiosis and Parkinson's Disease until I studied it online.
I'd like to suggest that you spend some time at Dr. Costantini's website; read the Therapy page, the FAQs, the About Dr. Costantini, and watch the patient videos.
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RE: Rapid Deterioration?
@Energia said in Rapid Deterioration?:
Desperate for any kind of help. Myriad of health issues. History of chronically increased cortisol levels ( stress related, no cushings). Many signs typically associated with cushings, with the worst being skin thinness followed by muscle and joint/bone weakness. Very underweight, difficulty putting on and maintaining weight bordering cachexic looking. Sensitivity to most foods, so that doesn't help. Indigestion/ GERD elicit arrythmias (SVT), so I must be careful with food intake. Sudden movements also can trigger this rhythm. Issues have been going on for years, but have hit breaking point and progressing rapidly. Skin rapidly becoming too thin to the point where almost every blood vessel is visible, new fine line wrinkles popping up seemingly every day (and this is no exaggeration). Can't even smile slightly without getting pretty severe redness in face and visible veins due to the thin skin. Petechiae everywhere, new moles popping up. Extremely dry hair and skin, regardless of hydration. I thought it was all attributed to cortisol issues, but recently I have a strong suspicion of ehlers danlos. Joints extremely unstable/ pop extremely loudly when manipulated. Internal organs feel like they're hanging on by a thread (possible hiatal hernia?) Severe social anxiety/uneasiness which causes a cortisol/adrenaline response. Took beta blocker for many years but weaned off few years ago. Thinking about restarting it to help mitigate some tissue/muscle damage from adrenaline. Neurological issues. I could go on further, but basically every organ system seems to be wasting away and quite rapidly at this point. Don't know what to do as I've become extremely sensitive to almost every food and even just eating causes fatigue. Don't know how fixable any of this is at this point, especially the collagen/ thin skin issues, as I've read that once skin has thinned out it can't really be regrown. Although maybe the bioenergetic theory says otherwise? Anyone have any knowledge on this or any of the other issues I mentioned? Any advice would be greatly appreciated. Thanks in advance.
Magnesium lowers cortisol. see here: Magnesium Status and Stress: The Vicious Circle Concept Revisited
Your description above sounds like thiamine deficiency/beriberi. see here: https://www.hormonesmatter.com/thiamine-deficiency-in-modern-medical-practice/
also:
Hiding in Plain Sight: Modern Thiamine DeficiencyThiamine and magnesium work together in the body. Supplementing thiamine improves tolerance for magnesium.
see also: https://www.multibriefs.com/briefs/icim/thiamin.pdfHypothyroidism symptoms and thiamine deficiency symptoms have some similarities because each of these block oxidative metabolism. It can get confusing. Also, the thyroid needs thiamine to do its job.
Ray Peat explained that adrenaline is released when blood sugar gets too low which is supposed to signal to the liver to release stored sugar into the blood stream. If the liver is unable to store sugar it won't be able to release any. If that happens, then cortisol is released to dissolve body tissues to provide glucose to the heart and brain. The liver needs thiamine to work properly. If there's a thiamine deficiency, the liver can't do a good job of storing sugar etc.
In addition, the mitochondria need thiamine to burn glucose for cellular energy. If this process is blocked (from no thiamine), then from the body's perspective there is a lack of glucose getting turned into energy. This can cause the release of adrenaline, then cortisol, resulting in tissue wasting.
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RE: Endotoxin Inflammation Stack
@herayclitus said in Endotoxin Inflammation Stack:
(obviously not medical advice)
I've been dealing with some chronic inflammatory symptoms recently that seem to be endotoxin-related (anhedonia, loss of appetite, nausea, low-grade fever, difficulty sleeping, diarrhea, migraines, etc.) I found not getting enough protein and fat to be the main triggers.
This stack worked for me almost as well as antibiotics:
- Zinc, 120mg
- Quercetin, 1g
- Methylene blue, 2mg
- Aspirin, 1g
- T3, 12μg (split into 2 doses)
- Cyproheptadine, 3mg (in the evening)
The dosing for everything is pretty modest, except for the zinc (I think the high-dose zinc is essential though)
I was curious if anyone else had a similar experience, and what worked for youI think that intestinal permeability is the main problem re. endotoxin. If the endotoxin (LPS) stays inside the intestine and does not get into the bloodstream then the systemic inflammation doesn't happen and the allergies/sensitivities to partially digested food molecules don't happen either.
Ray Peat told me in an email exchange (sorry, don't have it now to share) that thiamine and magnesium are needed to heal the gut. High dose thiamine hcl + magnesium glycinate worked for me. I also supplemented with other b vitamins during that time, but I only high dosed the thiamine. I used thiamine hcl.
link:
https://www.eonutrition.co.uk/post/thiamine-deficiency-a-major-cause-of-sibo
also:
https://www.hormonesmatter.com/sibo-ibs-constipation-thiamine-deficiency/
and
https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/dietary-supplementation-of-thiamine-enhances-colonic-integrity-and-modulates-mucosal-inflammation-injury-in-goats-challenged-by-lipopolysaccharide-and-low-ph/8B5E668F2BD04E289AA015E7A77680B3There is discussion online that thiamine deficiency contributes to leaky blood/brain barrier too. It is mentioned as the cause of brain damage in alcoholism; the alcohol depletes the thiamine, the bbb is compromised, then heavy metals (notably iron) leak into the brain causing damage. Something about thiamine being needed for tight junctures regarding the epithelial cells. Can't find it now....
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RE: Vitamin B6 supplement makes me feel great, why? Safe for long-term use?
@MasterPeatler said in Vitamin B6 supplement makes me feel great, why? Safe for long-term use?:
You probably have high lactate. Try adding in mucuna pruriens or anything which boosts dopamine.
Thiamine is known to reduce lactate: Severe lactic acidosis reversed by thiamine within 24 hours
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RE: Vitamin B6 supplement makes me feel great, why? Safe for long-term use?
@LucH said in Vitamin B6 supplement makes me feel great, why? Safe for long-term use?:
Hi,
Thiamine HCL is safe up to 200-250 mg, according to studies but you need to take into account some parameters, in order not to suffer from side-effects (the brain protects itself. No passata => lack of glycine). Too much of a good thing is bad.Got links to corroborate this statement about thiamine hcl "safe up to 200-250mgs"? Is this referring to oral doses or by injection? If by the oral route, this is a very low dose as thiamine hcl has poor absorption via the intestine. Low dose thiamine is believed to be carcinogenic whereas high dose oral thiamine hcl (greater than 2500mgs/day from memory) is believed to be anti-carcinogenic.
https://pubmed.ncbi.nlm.nih.gov/11488910/
also this one:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963161/ -
RE: Reddit Thread Full Of People With Garbage Metabolism Acting Like It's Normal
@yerrag said in Reddit Thread Full Of People With Garbage Metabolism Acting Like It's Normal:
it's unfortunate they're smarter than most and I think would be n the higher percentiles in aptitude but are already programmed like by the system- zeitgeist and pop culture and formal education.
having fully been indoctrinated into the wrong ideas of health while having technical smarts but not passing the metaphysical rigors of critical thought processes that enrich the minds of medieval to renaissance stalwarts that are not so dependent on evidence-based discoveries that are often gamed in our times
lacking the ability to connect the dots in the face of incomplete data but able to approximate nonetheless optimal solutions for practical use
I see this kind of reddit mindset when I engage members of www.arstechnica.com and see their Achilles heel when it comes to the medical side of things
they would end their existence in sudden deaths at a young age or wither away in a nursing home intoxicated with a daily cocktail of pharma drugs
yep.
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RE: Creatine and Ray Peat
@yerrag said in Creatine and Ray Peat:
@mostlylurking I think (I have not been reading a lot lately so I could be wrong) that anaerobic glycolysis is wasteful of thiamine, and that thiamine mega dosing helps, but clearing the capillaries of obstruction to make oxygen available to the brain fully is the way to fixing Parkinson's. Thiamine megadosing helps by compensating for the inefficiency and wastefulness of anaerobic glycolysis.
Hi yerrag, thanks for the link; I always value your insight. I read through your post and immediately thought of a Ray Peat audio when he discusses vitamin K2 for removing calcium in the circulatory system.
I believe my own thiamine deficiency/functional blockage fall of 2020 derailed my calcium storage which usually means the calcium that is supposed to get stored in the bones gets stored in the soft tissue (including the blood vessels) instead. Peat related a story about a doctor he knew that used high dose K2 (40-50mgs?) to resolve his hypertension.
Thiamine is needed for good oxidative metabolism. When it is deficient, the end product of the process is lactic acid instead of carbon dioxide. If things are working right, the carbon dioxide drags the calcium inside the cell out when the carbon dioxide exits the cell (from memory - A Peat explanation from somewhere). So it makes sense that calcium storage would get derailed in a thiamine deficiency.
Here's a link or two:
https://bioenergetic.life/?q=k2
The one with the story about the doctor high dosing the K is in there somewhere....
also this:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926526/Please note that vitamin D, needed for the immune system to work, also is responsible for making calcium get stored in the bones; in order to do this, there needs to be vitamin K available. So I think both D and K would be helpful.