Interesting find. I read through the study Danny linked and it does look promising, though it's worth remembering it was done in mice, not humans, so the jump to "here's how to lose weight" is a bit of a stretch until there's human trial data backing it up.
The RMR angle makes sense with what's been observed in other calorie restriction studies though, where the body tends to adapt by slowing down. If methionine/cysteine restriction sidesteps that adaptive response, that would actually be a meaningful difference mechanistically.
One thing I'd be curious about is how this plays out long term. Both methionine and cysteine are still essential, cysteine especially plays into glutathione production, so there's probably a sweet spot rather than "lower is always better." The chart is a handy reference for where different foods land, but I'd treat it as a general guide rather than something to follow strictly, especially for anyone already eating a fairly balanced diet.
Has anyone here actually tried adjusting their protein sources around this and noticed a real difference in energy or body temp?
