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Reversal of hair loss in Mice with “sugar gel”

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  • L
    LetTheRedeemed
    last edited by LetTheRedeemed Aug 6, 2024, 3:30 PM Jul 29, 2024, 5:33 AM

    I’d love to hear thoughts on this… it’s pretty peaty unless there is something about the sugar used that’s not optimal that I don’t know about?

    They used deoxyribose in a gel on the mice. It’s a natural sugar in animals and humans — it shouldn’t be dangerous…

    https://out.reddit.com/t3_1eemuge?app_name=ios&token=AQAA92-nZojyf05Lfx8fT1k__V0nuTSjSgXtTjVJf3Yv4uCHkvfF&url=https%3A%2F%2Fwww.sciencealert.com%2Fsurprise-hair-loss-breakthrough-sugar-gel-triggers-robust-regrowth

    EDIT: Danny did NOT say it increases NO. This is false

    H W L C 4 Replies Last reply Jul 29, 2024, 10:19 AM Reply Quote 0
    • L
      LetTheRedeemed
      last edited by LetTheRedeemed Jul 29, 2024, 5:54 AM Jul 29, 2024, 5:45 AM

      “Ribose sugar has a hydroxyl (OH) group at position 2, whereas deoxyribose sugar has a hydrogen (H) atom at position 2.”

      https://byjus.com/biology/difference-between-deoxyribose-and-ribose/#:~:text=The structure of Ribose and,more stable than ribose sugar.

      Z 1 Reply Last reply Jul 30, 2024, 12:45 AM Reply Quote 0
      • H
        Hearthfire @LetTheRedeemed
        last edited by Jul 29, 2024, 10:19 AM

        @LetTheRedeemed

        So where do we buy it? I'm assuming it's not the same as D-Ribose that's on Amazon?

        Didn't Ray Peat say something about sugar might be beneficial topically for hair loss? I remember this being discussed recently, either here or about a thread that was on the old forum.

        O L 2 Replies Last reply Jul 29, 2024, 3:21 PM Reply Quote 0
        • O
          OliverCloasov @Hearthfire
          last edited by Jul 29, 2024, 3:21 PM

          @Hearthfire Yeah they're not the same and it takes a complex enzyme mediated reaction to convert D-ribose to deoxyribose from what I'm reading.
          I recall Dr. Peat mentioning sugar being good for hair, but I can't remember the context.
          I'm definitely interested in this development, I'll be looking into whether it's possible to buy it. So far I haven't found a source unfortunately

          1 Reply Last reply Reply Quote 0
          • O
            OliverCloasov
            last edited by Jul 29, 2024, 3:25 PM

            Sigma-Aldrich has it, about $100 per 5g though
            https://www.sigmaaldrich.com/US/en/product/aldrich/121649

            1 Reply Last reply Reply Quote 0
            • O
              OliverCloasov
              last edited by OliverCloasov Jul 29, 2024, 3:29 PM Jul 29, 2024, 3:28 PM

              Cheaper here https://www.caymanchem.com/product/29072/2-deoxy-d-ribose

              Interesting snippet from their description:
              "Topical administration of 2-deoxy-D-ribose increases blood vessel formation and accelerates wound healing in a rat full-thickness cutaneous wound model."

              A L ? 3 Replies Last reply Jul 29, 2024, 3:59 PM Reply Quote 0
              • A
                AinmBeo @OliverCloasov
                last edited by Jul 29, 2024, 3:59 PM

                @OliverCloasov Yes, but they won't let you order unless you are a business or lab.

                O 1 Reply Last reply Jul 29, 2024, 6:11 PM Reply Quote 0
                • O
                  OliverCloasov @AinmBeo
                  last edited by Jul 29, 2024, 6:11 PM

                  @AinmBeo Ah you're right, unfortunate

                  1 Reply Last reply Reply Quote 0
                  • L
                    LetTheRedeemed @Hearthfire
                    last edited by Jul 29, 2024, 6:44 PM

                    @Hearthfire yeah d-ribose is different. I know, I forget what context he said that about, too - like topical or just higher consumption.

                    1 Reply Last reply Reply Quote 0
                    • L
                      LetTheRedeemed @OliverCloasov
                      last edited by LetTheRedeemed Jul 29, 2024, 6:46 PM Jul 29, 2024, 6:46 PM

                      @OliverCloasov @AinmBeo @Hearthfire
                      I'm open to a group buy if anyone of us can find a supplier to private individuals.

                      or, what if we all beseeched Georgi to make an experimental cosmetic in a one off batch and we be his guinea pigs? 😄

                      O 1 Reply Last reply Jul 29, 2024, 11:11 PM Reply Quote 0
                      • ?
                        A Former User @OliverCloasov
                        last edited by Jul 29, 2024, 8:20 PM

                        @OliverCloasov it increases NO so according to danny roddy it is le bad

                        O L 2 Replies Last reply Jul 29, 2024, 11:12 PM Reply Quote 0
                        • O
                          OliverCloasov @LetTheRedeemed
                          last edited by Jul 29, 2024, 11:11 PM

                          @LetTheRedeemed I'm open to it

                          1 Reply Last reply Reply Quote 0
                          • O
                            OliverCloasov @A Former User
                            last edited by Jul 29, 2024, 11:12 PM

                            @sneedful Interesting, did he elaborate on the mechanism and the degree?

                            ? 1 Reply Last reply Aug 5, 2024, 5:35 AM Reply Quote 0
                            • Z
                              zorba990 @LetTheRedeemed
                              last edited by Jul 30, 2024, 12:45 AM

                              @LetTheRedeemed Wonder what would happen if I bubble hydrogen through ribose infused water?

                              Found this on Amazon : https://www.amazon.com/RPI-2-Deoxy-D-Ribose-500-Grams/dp/B01N0X8O06

                              1 Reply Last reply Reply Quote 0
                              • L
                                LetTheRedeemed @A Former User
                                last edited by Jul 30, 2024, 1:05 AM

                                @sneedful dangit. in that case it could be working on hair growth thru the estrogen function: increase water retention, ie bloodflow

                                1 Reply Last reply Reply Quote 0
                                • L
                                  LetTheRedeemed
                                  last edited by Jul 30, 2024, 1:07 AM

                                  Anybody recall Peat's quote on sugar helping hair growth? was he talking topical? I wonder what topical glucose + ATP + Progest E might do.

                                  H 1 Reply Last reply Jul 30, 2024, 5:22 PM Reply Quote 0
                                  • B
                                    bot-mod
                                    last edited by Jul 30, 2024, 10:34 AM

                                    This is so simple I could believe in it.

                                    Thanks for sharing it.

                                    L 1 Reply Last reply Jul 30, 2024, 5:39 PM Reply Quote 0
                                    • H
                                      Hearthfire @LetTheRedeemed
                                      last edited by Jul 30, 2024, 5:22 PM

                                      @LetTheRedeemed

                                      I found this thread talking about it, from a podcast/conversation with Ray Peat and Danny Roddy titled
                                      "Lost Conversations with Ray Peat #1: The Purpose of Hair, Luciferianism, and Obama as a CIA Creation​

                                      https://raypeatforum.com/community/threads/did-ray-peat-just-recommended-topical-honey-for-hair.50151/

                                      Looks like that episode has been nuked off the internet by the censors. Probably for that title and the discussion content.

                                      L 1 Reply Last reply Jul 30, 2024, 5:39 PM Reply Quote 0
                                      • L
                                        LetTheRedeemed @Hearthfire
                                        last edited by Jul 30, 2024, 5:39 PM

                                        @Hearthfire brooo you came thru king.

                                        I'm thinking a topical spray of glucose + a pro-energy substance like t3/niacinamide/aspirin!

                                        1 Reply Last reply Reply Quote 0
                                        • L
                                          LetTheRedeemed @bot-mod
                                          last edited by Jul 30, 2024, 5:39 PM

                                          @ThinPicking right? Now I'm even more excited to try Ray's suggestion of topical glucose.

                                          1 Reply Last reply Reply Quote 0
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