Glucose loading cures everything?
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Has anybody here longterm success with this protocol? I did yesterday 4 times a day one dextro energy ( 5g dextrose) just to see what happened? It reaches directly the brain and I get calm but after 30-60 minutes I get hypoglycemic response. Last week I did also what Ray mentioned in one of his videos 1 pound additional sugar in 3 days to reset the thyroid from stress. I did half a pound what it was really great more energy more calm and some effect on the thyroid where it was loosen up not so tight anymore in the thyroid area. If you hear Dr. Stephens Videos u here like nearly everybody has instant relief from his protocol I think this doesnt match with the reviews here and on RPF
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@S-Holmes Which video on his website? Right now I'm not seeing anything at https://www.peakneuropsych.com/ but I don't know if that's the site you are referencing.
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@Mr-X said in Glucose loading cures everything?:
Has anybody here longterm success with this protocol? I did yesterday 4 times a day one dextro energy ( 5g dextrose) just to see what happened? It reaches directly the brain and I get calm but after 30-60 minutes I get hypoglycemic response. Last week I did also what Ray mentioned in one of his videos 1 pound additional sugar in 3 days to reset the thyroid from stress. I did half a pound what it was really great more energy more calm and some effect on the thyroid where it was loosen up not so tight anymore in the thyroid area. If you hear Dr. Stephens Videos u here like nearly everybody has instant relief from his protocol I think this doesnt match with the reviews here and on RPF
I'm still trying the protocol; approximately 3 months in. So I can't say much one way or the other.
However, I agree with you. From Dr. Stephens' videos, it sounded like basically instant relief across the board, whereas that is not what we are seeing in these forums. I've seen enough positive reports to think maybe there's something to this protocol, but I've seen enough reports conflicting with Stephens' representation to question its veracity.
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@jjk_learning did u get than instant relief after a few days? Or are you different person after these 3 months are there things which are better than before?
I dont know if hes right with his assumptions why it is working, I think we all agree that our brains needs a huge amount of sugar to function. Many dont saw the relief from a high sugar diet from peat many dont saw a relief from the glucose protocol. Many took care also of the cofactors b1, potassium and so on but also dont saw a relief.
I think glucose + t3 could be a good combo
My most memorable bioenergetic moment in my life was when I transferred from t4 only and added additional t3. I was lying on my couch and my eyes was falling backwards such a chill mode calm happy. Like the first time energy in my brain for years, but then next days i get huge adrenaline spikes but thats another story
Also i liked the explanation from @gentlepotato
in this thread would like to know how is it going with his protocol -
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I'm also 3 months on the protocol. My husband too. He is doing really well and I have good and bad days, but remember Dr. Stephens says it takes 4 to 12 months for your body to heal. Older people with more advanced pathology may take longer. It seems people are trying it for a day or a week, decide it doesn't work and just stop. I'm giving it the full test.
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Hi everyone,
Thanks for sharing! I've been reading, but not had the energy to post. I've had similar thoughts and questions, and also had the impression that people saw relief right away. That's not happened for me yet.
@S.Holmes, so he says at least 4 months before you may see some results? I had missed that. I am planning to stick with it 6-9 months, as that's what he suggested. In the video I've seen where he talks about it, I think he said 9 months for people older than 70?
I started at the beginning of July. I had some increase in energy the first month, and then - I think - my immune system started waking up. I had two 36 hour very obvious immune responses, and then a bunch of smaller ones, lasting a few hours. Whatever it's fighting in the chest it's not won yet - I also sense it's fighting something in the brain.
I have a wonderful GP and have benefited from her perspective on a regular basis; it's easy to focus on what isn't better, but there are also many positive changes - and if this is the immune system waking up, I believe that is major.
I'm trying to be patient and think that if this was an active infection and my immune system was fighting something, it may take weeks or even months to fight off a pathogen. From what I understand the Itaconate shunt is activated by the innate immune system (which we are born with), and when the adaptive immune system turns on it's switched "off" - and that the issues many of us have is because the adaptive immune system never takes over, so the Itaconate shunt continues.
I have much more brain fog than I did in July, and didn't have the capacity now to double check if I understand it correctly, but if anyone wants to and have the capacity Rob Phair talks about this in this video: [https://youtu.be/PCnkkLlyVMk?si=Qqnjpp1vWus6N4Fa](link url); chapters Krebs cycle and Consequences, and perhaps more.
That leaves room for reactivation of viruses, from what I can gather, and that's certainly been the case for me. I'm hopeful that what's happening now is good long term.
If this is the immune system fighting something that would explain why my cycle is affected negatively. I'm curious if anyone has a similar experience. Anyone with a cycle, who's been doing this for 3 months or more?
I forgot to mention I've switched to 3x4 and 2 tbsp before bedtime, totalling 14 a day. The two times I've tried 3 at night I get a brutal stomach ache, which I don't do during the day, so I'm sticking with 2. Every hour worked well for me at the beginning, I think I store glucose poorly, so it made sense. Then my gut feeling said to switch a couple of weeks ago.
Overall lots of my markers are positive, and I'm not having many issues with the protocol. But I'm quite exhausted and feel introverted. I'm taking it as a sign to not do much, and hope this will allow my body to do what it needs to.
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@gentlepotato said in Glucose loading cures everything?:
Hi everyone,
Thanks for sharing! I've been reading, but not had the energy to post. I've had similar thoughts and questions, and also had the impression that people saw relief right away. That's not happened for me yet.
@S.Holmes, so he says at least 4 months before you may see some results? I had missed that. I am planning to stick with it 6-9 months, as that's what he suggested. In the video I've seen where he talks about it, I think he said 9 months for people older than 70?
I started at the beginning of July. I had some increase in energy the first month, and then - I think - my immune system started waking up. I had two 36 hour very obvious immune responses, and then a bunch of smaller ones, lasting a few hours. Whatever it's fighting in the chest it's not won yet - I also sense it's fighting something in the brain.
I have a wonderful GP and have benefited from her perspective on a regular basis; it's easy to focus on what isn't better, but there are also many positive changes - and if this is the immune system waking up, I believe that is major.
I'm trying to be patient and think that if this was an active infection and my immune system was fighting something, it may take weeks or even months to fight off a pathogen. From what I understand the Itaconate shunt is activated by the innate immune system (which we are born with), and when the adaptive immune system turns on it's switched "off" - and that the issues many of us have is because the adaptive immune system never takes over, so the Itaconate shunt continues.
I have much more brain fog than I did in July, and didn't have the capacity now to double check if I understand it correctly, but if anyone wants to and have the capacity Rob Phair talks about this in this video: [https://youtu.be/PCnkkLlyVMk?si=Qqnjpp1vWus6N4Fa](link url); chapters Krebs cycle and Consequences, and perhaps more.
That leaves room for reactivation of viruses, from what I can gather, and that's certainly been the case for me. I'm hopeful that what's happening now is good long term.
If this is the immune system fighting something that would explain why my cycle is affected negatively. I'm curious if anyone has a similar experience. Anyone with a cycle, who's been doing this for 3 months or more?
I forgot to mention I've switched to 3x4 and 2 tbsp before bedtime, totalling 14 a day. The two times I've tried 3 at night I get a brutal stomach ache, which I don't do during the day, so I'm sticking with 2. Every hour worked well for me at the beginning, I think I store glucose poorly, so it made sense. Then my gut feeling said to switch a couple of weeks ago.
Overall lots of my markers are positive, and I'm not having many issues with the protocol. But I'm quite exhausted and feel introverted. I'm taking it as a sign to not do much, and hope this will allow my body to do what it needs to.
Thank you for your feedback! I had some viral flare ups about 1 month in. One was particularly painful (shingles), but none in weeks. I still have some issues, headaches, allergies, but many symptoms came and went and haven't come back. I also think supplements can be an issue. Dr Stephens says when the macros (glucose being the primary one) are being met, you may find the micros can be reduced or eliminated. I think that's because digestion is improved and we start getting more of them from food. That seems to have happened with me.
Fatigue can be an issue, but the body uses a lot of energy when it's healing. I find I do need a midday rest.
I'm fascinated with the itaconate shunt theory, but I don't know if it has been fully proven yet. I looked for research updates a few weeks ago and didn't find any.
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I've thought the same about deficiencies becoming less of a problem when the system works better. Not only because of digestion, but if you have multiple shunts you'll have imbalances and likely deficiencies, and when that's avoided micro nutrients are not used up as fast and can be used for the intended jobs.
I'm fascinated with the itaconate shunt theory, but I don't know if it has been fully proven yet.
Do that mean if Itaconate Shunt hypothesis specifically for ME/CFS has been fully proven? No one is suggesting it has been fully proven, it's still a hypothesis. That said, lots of fairly established truths in medicine are hypothesis and not fully proven. There's even been very established truths in medicine that were never researched, until a hypothesis and new research challenged the old approach.
I enjoy hypothesis because they're more see through. They are works in progress and in this case the hypothesis is explained in great detail, which means we can discuss the details! Is there anything specific about the hypothesis that doesn't resonate for you?
I looked for research updates a few weeks ago and didn't find any.
The ME/CFS researchers I've linked to are leading researchers on the hypothesis and the hypothesis is not the only thing they're working on, but I assume they (and other ME/CFS researchers) are basing their other research (creating a biomarker and/or treatments that work) on that hypothesis. I don't think you'll find research on the specific hypothesis on a regular basis, it may take years between every time they present new findings.
Thorough research takes a lot of time, but in this case it's also in large part because it's so hard to get funding for ME/CFS studies, unfortunately. Like I've said before I think that's an issue for medicine overall, because if you understand ME/CFS you may understand a lot of other illnesses. I also think the overall disregard for ME/CFS means that researchers in other fields aren't curious about this important research, and therefore it won't spread to other fields even if it would be applicable. It's incredibly sad to see the ramifications of the gasligthing and misinformation about the diagnosis.
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@gentlepotato said in Glucose loading cures everything?:
I've thought the same about deficiencies becoming less of a problem when the system works better. Not only because of digestion, but if you have multiple shunts you'll have imbalances and likely deficiencies, and when that's avoided micro nutrients are not used up as fast and can be used for the intended jobs.
I'm fascinated with the itaconate shunt theory, but I don't know if it has been fully proven yet.
Do that mean if Itaconate Shunt hypothesis specifically for ME/CFS has been fully proven? No one is suggesting it has been fully proven, it's still a hypothesis. That said, lots of fairly established truths in medicine are hypothesis and not fully proven. There's even been very established truths in medicine that were never researched, until a hypothesis and new research challenged the old approach.
I enjoy hypothesis because they're more see through. They are works in progress and in this case the hypothesis is explained in great detail, which means we can discuss the details! Is there anything specific about the hypothesis that doesn't resonate for you?
I looked for research updates a few weeks ago and didn't find any.
The ME/CFS researchers I've linked to are leading researchers on the hypothesis and the hypothesis is not the only thing they're working on, but I assume they (and other ME/CFS researchers) are basing their other research (creating a biomarker and/or treatments that work) on that hypothesis. I don't think you'll find research on the specific hypothesis on a regular basis, it may take years between every time they present new findings.
Thorough research takes a lot of time, but in this case it's also in large part because it's so hard to get funding for ME/CFS studies, unfortunately. Like I've said before I think that's an issue for medicine overall, because if you understand ME/CFS you may understand a lot of other illnesses. I also think the overall disregard for ME/CFS means that researchers in other fields aren't curious about this important research, and therefore it won't spread to other fields even if it would be applicable. It's incredibly sad to see the ramifications of the gasligthing and misinformation about the diagnosis.
The itaconate shunt is certainly a plausible explanation for glucose limiting effects following injury or trauma. Is it the only explanation? I don't know. All I know is that glucose therapy seems to be working for many. Maybe it reverses the shunt? If you find more information about this, I'm interested.
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can you provide somewhere with a summary of glucose loading protocol and any supportive cites? I can't watch a 1 or 2 hour video generally. I am grateful for your help.
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@Ecstatic_Hamster said in Glucose loading cures everything?:
can you provide somewhere with a summary of glucose loading protocol and any supportive cites? I can't watch a 1 or 2 hour video generally. I am grateful for your help.
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@Peatful said in Glucose loading cures everything?:
@Insomniac said in Glucose loading cures everything?:
@Peatful Exactly. Ray Peat doesn't even come up in the conversation. They've scrubbed him.
They never understood him.
Is it because the HPA axis becomes more sensitive with every trauma, and more ready to switch into sympathetic mode, stress cascade and ultimately more fat metabolism, inhibiting glucose metabolism. Maybe flooding the system with glucose stops the stress hormones from needing to be activated and slowly over time this makes the HPA axis less reactive through neuroplastic pathways being desensitised.
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Sorry, the above comment is in response to the question.”Why is glucose to the brain down regulated after every trauma?”
I’m new here and have messed up the quotebox!
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@josh said in Glucose loading cures everything?:
@Peatful said in Glucose loading cures everything?:
@Insomniac said in Glucose loading cures everything?:
@Peatful Exactly. Ray Peat doesn't even come up in the conversation. They've scrubbed him.
They never understood him.
Is it because the HPA axis becomes more sensitive with every trauma, and more ready to switch into sympathetic mode, stress cascade and ultimately more fat metabolism, inhibiting glucose metabolism. Maybe flooding the system with glucose stops the stress hormones from needing to be activated and slowly over time this makes the HPA axis less reactive through neuroplastic pathways being desensitised.
That sounds reasonable to me. Will take a closer look.
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@josh said in Glucose loading cures everything?:
Is it because the HPA axis becomes more sensitive with every trauma, and more ready to switch into sympathetic mode, stress cascade and ultimately more fat metabolism, inhibiting glucose metabolism. Maybe flooding the system with glucose stops the stress hormones from needing to be activated and slowly over time this makes the HPA axis less reactive through neuroplastic pathways being desensitised.
Do you have any sources for this understanding of the HPA axis? That the HPA axis "becomes sensitive", what does that mean? The neuroplastic approach is a very mental one, often seen mentioned by people who believe in the biopsychosocial model. I'd say it's very far from a bioenergetic approach.
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@S-Holmes said in Glucose loading cures everything?:
The itaconate shunt is certainly a plausible explanation for glucose limiting effects following injury or trauma. Is it the only explanation? I don't know. All I know is that glucose therapy seems to be working for many. Maybe it reverses the shunt? If you find more information about this, I'm interested.
I wonder if there's a misunderstanding, in regard to your previous posts, as well, before the one quoted here? I'm the only person who has written about the Itaconate Shunt as a possible explanation for glucose limitations, and why glucose might help reestablish the Krebs cycle. No new actual research is incoming about that. And I'm not looking for information to fully prove what I called an educated speculation, nor am I suggesting that it's the only explanation. I'm also not trying to persuade anyone; if it doesn't resonate (fully) for you, that's okay.
For me this kind of educated speculation (with sources etc) is an exploration, a tool, that allows me to give what is happening a framework. But it's more of a starting point for exploration; I'm not writing or sharing to conclude, and I'm quick to depart from a framework if reality doesn't fit in it.
I recognize my limitations and have a lot of humility about it all; I'm not here to do scientists work, and I think I've done a decent job at recognizing and pointing out the limits of my knowledge, as I'm sharing my speculations. I'm also not interested in being right, and when scientists (or anyone) find a more nuanced, better or completely different explanation, I'll applaud the work and be curious to read it.
All that said, the speculations I've shared are still a great tool for me. I wrote the speculation in July, before what I believe is my immune system started waking up. I wasn't expecting that to happen, because I didn't understand the immune system component of the Itaconate shunt back then. But when my immune system started waking up, I went back to my speculation, and it helped me make sense of what started happening. And that made it easier to rest and be patient, and not loose hope. It made it easier to hold the fear, when I got worse again. And it gave me a language so it is easier to speak to my GP about what is happening.
That way it's an incredibly helpful tool, and for me that's one of the best things I can hope for with this amateur dabbling into science. I'm delighted if it can be a supportive tool for others too, but I have zero expectation that it will resonate for everyone.
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@S-Holmes thanks!!
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Could somebody please maybe @gentlepotato or @S-Holmes share what is your current status and the status before the glucose loading protocol. What s gettin better what isnt still improved and how is the general wellbeing/health before/now maybe out of 10 or in precentage
Thanks in advance
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@Mr-X and another thing i have at the moment some huge gallblader/liver problems. This area is really tight and painful/stuck and so on. Ive try to combat this with hot water and TUDCA. I dont want to further burden the liver/gallbladder. Do you guys think the glucuse will directly the soaking up by the brain and will not end uo fettening the liver up like fructose?
Thx guys
