Methionine restriction shrinks tumors by ~90%.

Serotoninskeptic

Excess methylation is an epigenetic driver of cancer, but restricting methionine:

• Prevents tumor initiation
• Stops the proliferation of existing tumors

Glycine is our endogenous buffer of excess methylation from methionine.

Mauritio

@Serotoninskeptic very interesting. Cancer have what's called "methionine addiction".

Mauritio

@Serotoninskeptic can you link the study please?

MarkusAllenUSA

@Serotoninskeptic said in Methionine restriction shrinks tumors by ~90%.:

Glycine

So once again, are we to assume that an animal-based (which is high in Glycine) is the go-to way to get our nutrition?

Mauritio

@MarkusAllenUSA animal based is not necessarily high I glycine . In most cases it is way higher in methionine because of all the muscle meat.

Serotoninskeptic

@Mauritio Yea ideally more ground meats, broths, and gelatin would be included in an animal based diet which is usually not the case for most people who follow it.

Insomniac

@Mauritio said in Methionine restriction shrinks tumors by ~90%.:

@Serotoninskeptic can you link the study please?

I tried to track down the image hoping it would lead me to the study but no luck.

DavidPS

@Insomniac - I found the image and text. But I could not find the source material.

Mauritio

@DavidPS

i tried sending it to Google lens which send me to a Chinese website, which was semi helpful. Then i googled some of the Authors mentioned and it might be this study.

https://pubmed.ncbi.nlm.nih.gov/31061538/

DavidPS

@Mauritio - Yes, you are correct. The image is on page 5 of this pdf.

https://sci-hub.se/10.1038/s41591-019-0423-5

Insomniac

@DavidPS @Mauritio @Serotoninskeptic Ty

Mauritio

@DavidPS Thansk. I cant open this link. I think it's a sci hub issues. Most sci hub domains don't work for me anymore. And the ones that do work don't give me Andy results for the above link. Would you mind posting the PDF ?

DavidPS

@Mauritio - My first attempt using google drive.

https://drive.google.com/file/d/1zOOmUyjHK0aMckNWmIpAo0Mlqltr8WLy/view?usp=drive_link

Sam Crow

This is very interesting, but a few things I don't grasp:

While nowhere near as small as the methionine restricted tumor, the serine/glycine restricted tumor seems to be smaller than the 'complete' tumor. So, pushing glycine in addition to restricting methionine might not be the way to go? If the tumor growth is driven by methylation and glycine reduces methylation, then wouldn't the glycine restricted tumor grow even bigger?
In the pictures the glutamine restrited tumor looks bigger than the serine/glycine restricted tumor. But the graphs say otherwise. (This might be due to the fact that we just see 2 dimensions of the tumors in the pictures and it therefore is not a good depiction of its volume.)
They used the exact same 'complete' tumor for comparison in pictures 2 & 3 but another one in picture 1. Why is that?

(I assume the full study explains more about these things, but I can't open neither of the 2 links to the full text.)

CrumblingCookie

@Sam-Crow said in Methionine restriction shrinks tumors by ~90%.:

They used the exact same 'complete' tumor for comparison in pictures 2 & 3 but another one in picture 1. Why is that?

No, watch closely: They've used the very same complete tumor in all three pictures. But in the first picture it is turned by +90° clockwise and it looks fresher. So they probably did the methionine restriction first along with the control, then froze the control while they did the other two tests and took the complete control tumor back out for the later comparison photoshots.

Ecstatic_Hamster

methionine restriction is good. Also consuming methioninease is better. The enzyme which is present in many animals and molds, is now patented and very expensive, but it can result in a tumor completely disappearing as it gets rid of almost all methionine.

Mauritio

@DavidPS thanks I sent you a request .