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Pro Metabolic Substances Tier List

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  • A
    alfredoolivas @samson
    last edited by Mar 3, 2025, 7:09 PM

    @samson said in Pro Metabolic Substances Tier List:

    where are you getting that ozempic stops the stress response?

    My experience??

    Also, the anti-stress effects whilst dieting are why people love ozempic so much, and why the whole country will be on it. It makes dieting 90% easier I would say.

    Also, its a proven anti-depressant, and anti-anxiolytic in animal studies. Amongst other benefits, such as being anti-parkinsons

    1 Reply Last reply Reply Quote 0
    • P
      Peatful
      last edited by Mar 3, 2025, 7:23 PM

      Justify, defend or scientific research until your heart is content….

      This type of catabolic activity is not increasing mitochondrial respiration AFAIK

      The users I know have severe muscle wasting

      Peat has not endorsed it

      If you love it
      Good on you

      But
      S Tier Peaty is nonsense

      The further society drifts from the truth the more it will hate those who speak it.

      SD

      A 1 Reply Last reply Mar 3, 2025, 7:32 PM Reply Quote 0
      • Y
        yeyo12
        last edited by Mar 3, 2025, 7:24 PM

        Bromantane and Naltrexone is dope.

        Have tried many things here, and I mostly agree with this list.

        Except ozempic and mg glycinate lol

        I want to try Lisuride, I wonder how it compares to microdosing LSD which doesn't feel good for me.

        1 Reply Last reply Reply Quote 0
        • A
          alfredoolivas @Peatful
          last edited by Mar 3, 2025, 7:32 PM

          @Peatful It's been shown to have pro-mitochondria affects as well.

          P 1 Reply Last reply Mar 3, 2025, 7:41 PM Reply Quote 0
          • P
            Peatful @alfredoolivas
            last edited by Mar 3, 2025, 7:41 PM

            @alfredoolivas said in Pro Metabolic Substances Tier List:

            @Peatful It's been shown to have pro-mitochondria affects as well.

            I figured of course

            I have anecdotal and empirical evidence that it is - damaging

            The muscle loss alone is an indicator that it is not without risks or certainly contraindications

            Peat has said that organisms lose mass as they age or are closer to death

            Not here to debate

            Honestly
            Best of health to you

            The further society drifts from the truth the more it will hate those who speak it.

            SD

            1 Reply Last reply Reply Quote 0
            • ?
              A Former User
              last edited by Mar 3, 2025, 10:05 PM

              Wow, that's a lot of drugs. I'd like to see your medicine cabinet lol. I don't know why you'd even consider ozempic as a weight loss shortcut when you've got t3 and testosterone on your list. Hell, I'd take DNP over semaglutide without second thought if I was desperate enough to lose weight.

              Besides the side effects listed by Novo Nordisk and the media coverage of ozempic face and gastroparalysis, semaglutide sets you up for serious rebound. Some people even find that it stops working while you're on it. I'll have to dig up the study I found a while ago that showed that semaglutide prevented existing fat cells from storing lipids while causing a proliferation of new fat cells. Sounds like a recipe for disaster to me.

              A 1 Reply Last reply Mar 3, 2025, 10:18 PM Reply Quote 0
              • C
                caudillofranco @alfredoolivas
                last edited by Mar 3, 2025, 10:18 PM

                @alfredoolivas Solid tier list, but ozempic at top is questionable... Glad it helped you lose weight though 👍

                1 Reply Last reply Reply Quote 0
                • A
                  alfredoolivas @A Former User
                  last edited by alfredoolivas Mar 3, 2025, 10:19 PM Mar 3, 2025, 10:18 PM

                  @Metabolist said in Pro Metabolic Substances Tier List:

                  Some people even find that it stops working while you're on it. I'll have to dig up the study I found a while ago that showed that semaglutide prevented existing fat cells from storing lipids while causing a proliferation of new fat cells. Sounds like a recipe for disaster to me.

                  Hmmmm.... sounds like something thyroid hormone does
                  Triiodothyronine (T3) promotes brown fat hyperplasia via thyroid hormone receptor α mediated adipocyte progenitor cell proliferation

                  In all seriousness, anything that causes fat cells to brown, causes hyperplasia of fat cells, whic is why thyroid and GLP-1 both cause fat cell hyperplasia, as they both brown the fat cells. Brown fat cells have a lot less apoptosis than white fat cells.

                  @Metabolist said in Pro Metabolic Substances Tier List:

                  Besides the side effects listed by Novo Nordisk and the media coverage of ozempic face and gastroparalysis, semaglutide sets you up for serious rebound

                  Diabetic people are already prone to gastroparalysis lol, so of course if they are treated with semaglutide, they are at a further risk of gastroparalysis. It doesn't mean it happens to normal people.

                  Ozempic is given to the most hypometabolic people in society (obese and diabetic people), so of course there will be side effects, because as Ray said, anything is dangerous to a hypothyroid person.

                  @Metabolist said in Pro Metabolic Substances Tier List:

                  Wow, that's a lot of drugs. I'd like to see your medicine cabinet lol. I don't know why you'd even consider ozempic as a weight loss shortcut when you've got t3 and testosterone on your list. Hell, I'd take DNP over semaglutide without second thought if I was desperate enough to lose weight.

                  Because they don't work on me. DNP is made in China with hell knows what. I am no way taking 200mg of a heavy metal laden powder, probably made with chemicals fit for industrial use.

                  ? 1 Reply Last reply Mar 3, 2025, 10:45 PM Reply Quote 0
                  • A
                    Alomongerpete
                    last edited by Mar 3, 2025, 10:21 PM

                    Fascinating list. Thanks for sharing. Where do you get your Cabergoline from? Thanks.

                    A 1 Reply Last reply Mar 3, 2025, 10:22 PM Reply Quote 0
                    • A
                      alfredoolivas @Alomongerpete
                      last edited by Mar 3, 2025, 10:22 PM

                      @Alomongerpete said in Pro Metabolic Substances Tier List:

                      Reply

                      https://pharmacy-faster.com/

                      1 Reply Last reply Reply Quote 0
                      • ?
                        A Former User @alfredoolivas
                        last edited by Mar 3, 2025, 10:45 PM

                        @alfredoolivas I'm pretty certain semaglutide increased WAT along with brown. If you feel comfortable taking it then don't let me stop you. My point of contention is that the long term effects aren't fully known and rebound upon discontinuation is a real possibility.

                        How could testosterone and T3 not work on you? Sounds like a dosage or authenticity issue

                        A 1 Reply Last reply Mar 3, 2025, 11:02 PM Reply Quote 0
                        • P
                          Peatful
                          last edited by Mar 3, 2025, 10:56 PM

                          https://haidut.me/?p=2730

                          “A Brave New World”->

                          https://haidut.me/?p=2744

                          The further society drifts from the truth the more it will hate those who speak it.

                          SD

                          A 1 Reply Last reply Mar 3, 2025, 11:06 PM Reply Quote 0
                          • A
                            alfredoolivas @A Former User
                            last edited by Mar 3, 2025, 11:02 PM

                            @Metabolist For you to lose weight by increasing the metabolic rate, you know you would have to burn 500 extra calories a day to lose a pound a week? Testosterone and thyroid don't allow you to burn 500 more calories a day lol.

                            ? 1 Reply Last reply Mar 4, 2025, 2:55 AM Reply Quote 0
                            • A
                              alfredoolivas @Peatful
                              last edited by Mar 3, 2025, 11:06 PM

                              @Peatful Bone loss and excess catabolism can all be explained by much rapid and sustained weight loss.... if you lose more weight and your weight loss doesn't plateau you will lose more muscle. In interventional animal studies, where they simply weren't studying correlations and observations, GLP 1 agonists have been shown to be anti-catabolic to both bones and muscles.

                              I also saw another study that said the opposite about GLP 1 agonists effect on mental health.

                              But fair enough for sharing these studies. I personally have not experienced this, and have got even more stronger in the gym on semaglutide, but these are fair talking points.

                              1 Reply Last reply Reply Quote 0
                              • R
                                rohmilchbubi
                                last edited by Mar 4, 2025, 2:00 AM

                                How do you approach cabergoline - dosage, timing, frequency etc.?

                                What's your take on cabergoline vs pramipexol?

                                A 1 Reply Last reply Mar 4, 2025, 8:54 AM Reply Quote 0
                                • ?
                                  A Former User @alfredoolivas
                                  last edited by Mar 4, 2025, 2:55 AM

                                  @alfredoolivas They absolutely do in supraphysiological doses. Try perusing some bodybuilder forums. I wouldn't recommend you try high t3 though as it will send your appetite through the roof.

                                  Yes, yes 3500cal in a pound of fat, assuming that you burn it exclusively. Is ozempic known to preserve lean mass and bone density compared to a solid exercise and diet plan alone?

                                  A 1 Reply Last reply Mar 4, 2025, 8:46 AM Reply Quote 0
                                  • A
                                    alfredoolivas @A Former User
                                    last edited by alfredoolivas Mar 4, 2025, 8:48 AM Mar 4, 2025, 8:46 AM

                                    @Metabolist They don't, studies have shown healthy men taking testosterone, don't get any change in metabolic rate, and thyroid for barely to change the metabolic rate and weight loss. On that topic, thyroid has shown to be very catabolic in humans but people love to keep quiet about that one here.

                                    I have tried different brands of thyroid, taken up to 300mcg a day, and have not lost weight. Same goes for testosterone. I am on bodybuilder forums, and thyroid is only useful when yourbody stops burning fat during a calorie deficit, and testosterone isn't even talked about for a fat loss agent, even though it has fat loss related benefits like muscle preservation.

                                    Youtube Video

                                    ? 1 Reply Last reply Mar 4, 2025, 5:09 PM Reply Quote 0
                                    • A
                                      alfredoolivas @rohmilchbubi
                                      last edited by Mar 4, 2025, 8:54 AM

                                      @anib 0.25mg twice a week.

                                      I haven't got a good answer. Pramixepole seems to have some opposite effects than the ergot derivatives. Pramixepole encourages fat gain for example, whereas cabergoline and bromocriptine promote it, pramixepole is more asssociated with compulsive dissorders etc, I just don't trust Pramixepole, it is a lot stronger than cabergoline, I read it is stronger than dopamine by 100%+, whereas cabergoline is around 70% as strong as dopamine. Seems very artificial. Just my intuition really, no good reason.

                                      1 Reply Last reply Reply Quote 0
                                      • M
                                        metabolicmilk
                                        last edited by Mar 4, 2025, 11:31 AM

                                        @alfredoolivas said in Pro Metabolic Substances Tier List:

                                        Thyroid (T3/T4

                                        @alfredoolivas What does your thyroid dosing look like? How much T3/T4 a day? how many times a day and do you recommend any specific brand?

                                        Thanks for the post 🙂

                                        A 1 Reply Last reply Mar 4, 2025, 4:29 PM Reply Quote 0
                                        • KvirionK
                                          Kvirion @alfredoolivas
                                          last edited by Kvirion Mar 5, 2025, 2:52 PM Mar 4, 2025, 2:38 PM

                                          @alfredoolivas Interesting list - thanks, but with all the respect, it's not (holistic) Peating, it's just biohacking at best...

                                          "The only supplements that are very safe to take orally are aspirin, cascara, some kinds of thyroid, small amounts of penicillin (30 mg), cyproheptadine (one-half to one milligram), and progesterone." ~Ray Peat, PhD

                                          A little learning is a dangerous thing ;
                                          Drink deep, or taste not the Pierian spring :
                                          There shallow draughts intoxicate the brain,
                                          And drinking largely sobers us again.
                                          ~Alexander Pope, An Essay on Criticism

                                          A 1 Reply Last reply Mar 4, 2025, 4:30 PM Reply Quote 0
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