Reversal of hair loss in Mice with “sugar gel”
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@wester130 is there a known mechanism? I've often been cautious of herbalistic remedies that work, as they may be working on the NO pathway...
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Boosts blood circulation, anti-inflammatory, blocks DHT in the scalp, anti-fungal, anti-microbial, probably effective against parasites like demodex mites.
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Carnosic Acid: This compound has antioxidant and anti-inflammatory properties. It improves scalp health by reducing inflammation and oxidative stress, which can contribute to hair loss. It may also stimulate blood circulation to the scalp, enhancing nutrient delivery to hair follicles, promoting growth.
Ursolic Acid: This compound is believed to inhibit 5-alpha-reductase, an enzyme that converts testosterone to dihydrotestosterone (DHT). -
for people wanting a herbal, ethanol based solution, this is the best I could discover
menthol crystals.
camphor crystals
thymol crystals
caffeine
niacinamidemix into vodka
it avoids the greasiness of essential oils
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@LetTheRedeemed I don’t think NO pathway is necessarily always bad. If you’re underproducing NO, you might actually benefit from it.
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@Mauritio said in Reversal of hair loss in Mice with “sugar gel”:
This study suggests that the higher G6PD is the more anagen hairs you have.
G6PD creates R5P (ribose-5-phosphate).
This might be why ribose could work.
Because ribose is also converted to R5P.
If you already have more R5P, you need to convert less G6P into it, and thus leaves more for glyocgen synthesis. So ribose indirectly increases glyocgen levels.Or it could have to do with nucleotide synthesis .
R5P is used for it and maybe nucleotide Synthesis is an overlooked player in hair loss ? Haven't looked into it.Makes me wonder if I should add some ribose to the above formula...
Does this imply that those with a G6PD deficiency would have trouble with hair?
@Mauritio said in Reversal of hair loss in Mice with “sugar gel”:
Interesting. The hair follicle seems to be use mostly aerobic glycolisis for energy production.
"...the hair follicle exhibits aerobic glycolysis, in that of the total glucose utilized by the hair follicle, only 10% is oxidized to CO2."
https://pubmed.ncbi.nlm.nih.gov/2045676/
This study goes hand in hand with the one above. It shows that hair follicles have their one corri cycle (producing glucose out of lactate) which makes sense since they're using mainly aerobic glycolisis, which provides lots of lactate as a waste product . They use that lactate and form glycogen out of it! Which in turn helps keep the hair follicle in anagen growing phases.
So if the hair can use lactate to make glycogen surely it can use glucose.
Usually glucose can either be directly metabolized to energy or converted to G6P via hexokinase serving as a building block for glyocgen .Which makes the glucose hypothesis even more attractive because the supply of glucose wouldn't have to be constant (which isn't realistic anyway) since the hair can synthesize glycogen and store it for when glucose levels drop, keeping the hair in an anagen phase.Another question: Is this related to total glycolysis or only the part that actually gets oxidized? Because if hair cells are predisposed to glucose oxidation in general, it would be great to reduce FFAs whether it's through max carb min fat or pyrucet or something else, so that the cells would experience a less hypoxic environment. Maybe this is why fat people often get hair loss?
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@engineer said in Reversal of hair loss in Mice with “sugar gel”:
Does this imply that those with a G6PD deficiency would have trouble with hair?
I would think so.
@engineer said in Reversal of hair loss in Mice with “sugar gel”:
Another question: Is this related to total glycolysis or only the part that actually gets oxidized?
I think it's more related to local glycolysis. Glycolisis is the physiological state of metabolism of the hair (and skin and wounds and other fast dividing tissues) .
I don't know how much systemic metabolism affects scalp metabolism.Dare to think.
My X:
x.com/Metabolicmonstr -
@Mauritio said in Reversal of hair loss in Mice with “sugar gel”:
I think it's more related to local glycolysis. Glycolisis is the physiological state of metabolism of the hair (and skin and wounds and other fast dividing tissues) .
This alone could turn out to be one of (if not) THE major risk factors for hair loss. Someone else mentioned it, but keto diets tend to be brutal to hair, likely because increased FAO > /\ FFAs > \/ glucose available to use.
So that would imply that to help stop hair loss or regrow it, all you'd need to do is increase glycolysis, which we know how to do.
Are there any studies on such a change actually delivering results?
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@engineer there was a guy on the rpf who had before and after pics of 7 months rubbing in topical progest-e.
Not that that exactly answers your question, but it at least is an example of pro-metabolic things helping hair metabolism as opposed to the common blood flow improvement methods. -
amazingly someone was talking about topical ribose 10 years ago
https://www.hairlosstalk.com/interact/threads/dermal-benefits-of-topical-d-ribose.69208/
and
and
https://immortalhair.forumotion.com/t11589-has-anyone-used-ribose?highlight=ribose
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I had a realisation
It is not sugar you need, but ATP, so things like Ribose would be better
I think some people confuse the two
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@wester130 someone quoted somewhere in here, that Ray said that the cells confuse pure ATP as leaking components from a damaged cell, and create an immune response, thus counterintuitive to use (I wonder if this is similar to how whole proteins induce a cytokine storm).
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@LetTheRedeemed what does this mean for people applying topical ATP precursors to their scalp?
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@wester130 Good q, it was implied that's bad, but I don't know beyond "immune response bad" is my assumption
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i think he meant direct ATP supplementation, I remember the quote, he said taking direct ATP was bad
the precursors like coq10, ribose, creatine, magnesium malate which covnert to atp look Okay.
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@wester130 oh wow so sorry I missed this, I thought you meant supplementation of ATP LOL.
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Some good anedotes online of people regrowing lots of hair using coq10 for extended periods.
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@Hearthfire topically?
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No, oral. Just regular coq10, 400mg.
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Will you be using ubiquinone? In my search to find if there is a pro-Peat consensus between the two versions, I see you mention about first using ubiquinol, but planned on switching to ubiquinone. Just curious of your take on it. I also see on that thread the mention of it being good for gum health. I used to use a toothpaste CoQ10 and used to have very good gums — per a dental check up after a 12 year absence. I think I'll attempt to kill two birds — hair and gums — with CoQ10.
