Topical Steroid Solubility and Absorbtion
-
I'm preparing to create a solution containing Testosterone, DHT, P4, and DHEA for topical administration.
Based on Haidut's product Cortinon, P4:DHEA ratio should be at least 3:1. For the T:DHT ratio, I want to try 4:3, with a 1:1 ratio of androgens to precursors. So, in total it would be T:DHT:P4:DHEA = 4:3:3:1.
Based on some of Haidut's research on RP forum, a solution containing 50% DMSO + 50% of "something else" (he listed ethanol, acetone, glycerol as options) should result in near 100% absorption of the steroids when administered topically.
So, I think 50% DMSO + 50% Ethanol would be a good place to start.
Now, down to the dosing. Based on the solubility data I was able to find for P4 (54.4 mg/mL = 13.6 mg/0.25mL in Ethanol), I think it's reasonable to expect to be able to dissolve 4mg T, 3 mg DHT, 3mg P4, 1mg DHEA in 0.25 mL of 50% Ethanol 50% DMSO. The 0.25 mL equates to roughly 5 drops from a dropper, with each drop being 0.05mL. I would consider 5 drops = 0.25mL to be a single dose.
I plan on sourcing from Purple Panda labs, and then homebrewing using insulin syringes to accurately measure the liquid ( 7.5 mL each of DMSO and Ethanol for a 60 day supply of one dose/day) and a milligram scale to measure the raw powders. To get around the drop size problem, I'll purchase a precision pipette to make sure I'm truly getting 0.25mL per dose.
What do you think of those ratios? Should I change any of them? My goal is to increase muscle mass and strength in the gym. I would consider taking this mixture pre-workout, as it should potentiate its effects rather quickly because of the lack of esters.
-
Did you experiment with this?
-
Following out of interest. Log your results
-
@Lothric I decided on dissolving T in vitamin E. Similar to progest-e except I will use T instead of P4.
-
@jamezb46
How has the experience in vitamin e been? What dosage are you using and what solubility did you achieve? -
Still waiting on my shipment from PPL. Will update this thread after I dissolve the powder and again after a few weeks of using it.
Hello! It looks like you're interested in this conversation, but you don't have an account yet.
Getting fed up of having to scroll through the same posts each visit? When you register for an account, you'll always come back to exactly where you were before, and choose to be notified of new replies (either via email, or push notification). You'll also be able to save bookmarks and upvote posts to show your appreciation to other community members.
With your input, this post could be even better 💗
Register Login