Vitamin D Receptor stops mitochondria respiration [Why vit D can cause problems] [1,25 vitamin D]
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@cs3000
You had mentioned relative lack of copper in this context of Mg and Zn and VDR activation making things worse and exacerbating underlying mitochondrial energy impairments.
Did you eventually supplement copper and did it profoundly fix these conditions for you?
Very interested in reading about this.
Thanks for having found and reported the 1,25D/VDR effect of inhibiting cellular copper uptake.
Have you made any approach in the meantime into resolving your underlying causes of elevated chronic inflammation/PAMPS/TLR?@cs3000 said in:
Th1 activity leads to paracrine extra-renal conversion of inactive 25D to active 1,25D, often depleting serum levels of measured 25D in order to increase active vitamin D (how can It deplete if theres 100x more 25 than 1,25 in plasma?) <←- NOT DIRECT DEPLETION , THE 1,25 EXCESS CAUSES ENZYME ELEVATION THAT METABOLISES 25
Afaik by drawing upon some of the same sources you've been using:
By measurements of serum levels (extracellular) of these hormones we only get a one-sided and distorted view on their balance between each other.
Since conversion to and activity of 1,25D are both predominantly intracellular processes there are concentration gradients to be accounted for.
I.e. only 1/10 of circulating serum 25D seeps across the cellular membranes and only 1/10 of intracellular 1,25D seeps outside, roughly. Both 25D3 and 1,25D3 are then essentially in the same potency range, could even be equimolar, with regard to exertion of their nuclear receptor binding intracellularly. -
i had similar symptoms than cs3000 described in the link above from drinking mostly raw milk and direct sun exposure(never had these symptoms from sunlight before i started drinking raw milk, and i have experienced these symptoms afterward in winter just from the raw milk), eating very good dattes temporary make me experience 0 bad effects from sunlight and if i have keep eating it at a certain point body even crave sunlight and sunlight exposure feel exhalting
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Apparently, 25D which is the metabolite of D3, inhibits 1-25D production
“...With high dose cholecalciferol therapy... PTH is physiologically down-regulated and therefore the synthesis of 1,25-D and dietary calcium absorption are reduced.” — Vaidya, et al. (2015)" -
Methylene Blue should be able to inhibit 1,25 conversion too if hydroxychloriquine can.
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@bio3nergetic Interdasting, we should get a list of inhbitors / factors that influence the conversion
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Thanks @user1. Do you mean dates as in the fruit, like medjool dates? Because of their c. 0.3mg/100gr copper content?
I remember I had sort of kept myself afloat for many months by consuming a few hundred grams of dates every day and had assumed their delayed sugar release and balancing potassium content to be the major reason. -
@CrumblingCookie said in Vitamin D Receptor stops mitochondria respiration [Why vit D can cause problems] [1,25 vitamin D]:
Thanks @user1. Do you mean dates as in the fruit, like medjool dates? Because of their c. 0.3mg/100gr copper content?
I remember I had sort of kept myself afloat for many months by consuming a few hundred grams of dates every day and had assumed their delayed sugar release and balancing potassium content to be the major reason.Yes this fruit, yet much softer and moistyer thab typical medjool or dattes
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@alfredoolivas Progesterone lowers 1,25 as well
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Is it possible to have copper deficiency, but normal levels of serum copper and ceruloplasmin, and serum free copper abnormally high?
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@BearWithMe estrogen can increase free copper while PUFA can increase estrogenic activity in inducing free copper or directly damaging enzymes related to copper utilization. Free copper is what contributes to toxicity. Total copper in a healthy system is what yields robust copper status.
