Reversal of hair loss in Mice with “sugar gel”
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@Hearthfire I know that (povidone) iodine is not usually considered Peaty, but I've been having great success with using it to treat ringworm infections on flesh, and toenail fungus. I'm kind of interested to see how it works for my dandruff as well... since that is usually thought of as a yeast infection. I'll have to give it a try and make a small thread for it if the result is good.
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@Rah1woot
I had tried topical iodine (diluted Lugol's) on my scalp before and wouldn't recommend it. I suspect the oxidative action of iodine is bad for hair follicles and the papillae.Although I've read about a peculiar association between those tiny hair muscles (for erecting hairs) and iodide, as in that those erector pilii don't function well in iodide deficiency, and that "disorderly" body or head hair which turns to all directions instead of a generally common alignment may therefore be a hint towards a lack of iodide. IME there's something to it.
Against fungal issues perhaps borax? Don't know for how long the aqueous solution must be allowed to soak in for good effects, though.
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@CrumblingCookie What method of application did you use for the iodine on the scalp?
I've had such great success with using povidone iodine (whose action is a delayed release of iodine) for other fungal infections that I'm still pretty keen to try it on the scalp, to be honest.
I believe what you say about the harm to the follicles, but I would also think it's not a huge deal if used for intermittent treatment, and then washed off.
But this is getting somewhat off the thread topic of sugar gel and hairloss.
I will make a separate thread @CrumblingCookie and tag you.
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I am positive even a small amount of iodine would help if you have a fungal infection in the scalp. How much did you use, CrumblingCookie? Did you notice it drying out your hair or something? If it was a large amount you tried, maybe just mixing in a couple drops with whatever shampoo you use, and increasing until you see negative effects would be the play. Then reduce it a bit.
My brother has been dealing with a ringworm infection on his hand, I'll be recommending he try the iodine. Thanks for that info. Will also try the borax.
@Rah1woot said in Reversal of hair loss in Mice with “sugar gel”:
But this is getting somewhat off the thread topic of sugar gel and hairloss.
I will make a separate thread @CrumblingCookie and tag you.I mean, this thread has evolved into a general discussion of hair loss and treatments already. But maybe it would be good to have a hair loss general so to speak, for easier discoverability for future users.
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I've been pondering on whether to also include D-Biotin in the topical to go along with dexpanthenol.
Wrt to topical apigenin, topical biotin, and topical oleanolic acid (olive tree leaves extract @Mauritio) there's a commercial product with these ingredients called Procapil supposed to induce hair strengthening and anti-hair loss treatment by improving poor scalp micro-circulation, follicle ageing and follicle atrophy. Interestingly, the same company also markets "Apiscalp" to fight dandruff, itching, dryness and hypersoborrhea. It's active ingredient is of course: Apigenin. And caprylic acid (antifungal). That's it. Elegant.
In the Procapil they actually include "biotinoyl tripeptide-1" for biotin, which is"a vitaminized derivative of Tripeptide-1, a matrikine that stimulates hair follicle metabolism and anchoring. It reduces hair loss by inhibiting DHT, improving blood irrigation, and activating hair growth genes [...] stimulating the production of anchoring molecules"*
"Tripeptide-1 (GHK peptide) is a fragment of collagen type I that stimulates collagen and hyaluronic acid synthesis, protects collagen fibers, and scavenges reactive carbonyl species. It helps prevent wrinkles, photo-aging, and DNA damage from pollution and sun exposure."*
Tripeptide-1 is actually synonymous with GHK. It's also synonymous with Prezatide. Peptide-interested people will have read about copper-GHK. I always wondered why I would want such extra copper. It seems the GHK-part itself is effective and can combine with other substances like biotin.
Overall, both topical biotin and topical tripeptide-1 appear interesting.
In an Italian study on short anagen syndrom in children (link), which is a special genetic condition, administration of oral biotin alone drastically improved the anagen:telogen ratio.
But I'm wary of biotin because it impedes the crucial B5-uptake so I'm liking the idea of topical administration (perhaps 0.1% 0.05%?) in combination with dexpanthenol of which the uptake shouldn't be inhibited by biotin. -
Just a quick update: i stoped applying because it was making my hair very dry. I suspect it was the alcohol.
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@Mauritio I like how solban (I make my own) makes my hair feel, very nice
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@Mauritio interesting. Thoughts on diluting with more water?
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@LetTheRedeemed Well that would take me waiting until all the damaged hair has grown out which would take about 1 year. After which I'm not going to damage my hair for another year by trying out a less strong version.
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has anyone tried tropical pycnogenol ?
it can work like minoxidil in its effect for increasing bloodflow and opening up blood vessels
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@Mauritio interesting… i personally haven't seen damage.
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@LetTheRedeemed good for you . Then keep going ! Don't want to discourage anyone. I think I just have sensitive hair.
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@Mauritio if you dont mind my asking, what does the damage look like?
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results from men who used rosemary oil
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@wester130 is there a known mechanism? I've often been cautious of herbalistic remedies that work, as they may be working on the NO pathway...
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Boosts blood circulation, anti-inflammatory, blocks DHT in the scalp, anti-fungal, anti-microbial, probably effective against parasites like demodex mites.
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Carnosic Acid: This compound has antioxidant and anti-inflammatory properties. It improves scalp health by reducing inflammation and oxidative stress, which can contribute to hair loss. It may also stimulate blood circulation to the scalp, enhancing nutrient delivery to hair follicles, promoting growth.
Ursolic Acid: This compound is believed to inhibit 5-alpha-reductase, an enzyme that converts testosterone to dihydrotestosterone (DHT). -
for people wanting a herbal, ethanol based solution, this is the best I could discover
menthol crystals.
camphor crystals
thymol crystals
caffeine
niacinamidemix into vodka
it avoids the greasiness of essential oils
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@LetTheRedeemed I don’t think NO pathway is necessarily always bad. If you’re underproducing NO, you might actually benefit from it.
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@Mauritio said in Reversal of hair loss in Mice with “sugar gel”:
This study suggests that the higher G6PD is the more anagen hairs you have.
G6PD creates R5P (ribose-5-phosphate).
This might be why ribose could work.
Because ribose is also converted to R5P.
If you already have more R5P, you need to convert less G6P into it, and thus leaves more for glyocgen synthesis. So ribose indirectly increases glyocgen levels.Or it could have to do with nucleotide synthesis .
R5P is used for it and maybe nucleotide Synthesis is an overlooked player in hair loss ? Haven't looked into it.Makes me wonder if I should add some ribose to the above formula...
Does this imply that those with a G6PD deficiency would have trouble with hair?
@Mauritio said in Reversal of hair loss in Mice with “sugar gel”:
Interesting. The hair follicle seems to be use mostly aerobic glycolisis for energy production.
"...the hair follicle exhibits aerobic glycolysis, in that of the total glucose utilized by the hair follicle, only 10% is oxidized to CO2."
https://pubmed.ncbi.nlm.nih.gov/2045676/
This study goes hand in hand with the one above. It shows that hair follicles have their one corri cycle (producing glucose out of lactate) which makes sense since they're using mainly aerobic glycolisis, which provides lots of lactate as a waste product . They use that lactate and form glycogen out of it! Which in turn helps keep the hair follicle in anagen growing phases.
So if the hair can use lactate to make glycogen surely it can use glucose.
Usually glucose can either be directly metabolized to energy or converted to G6P via hexokinase serving as a building block for glyocgen .Which makes the glucose hypothesis even more attractive because the supply of glucose wouldn't have to be constant (which isn't realistic anyway) since the hair can synthesize glycogen and store it for when glucose levels drop, keeping the hair in an anagen phase.Another question: Is this related to total glycolysis or only the part that actually gets oxidized? Because if hair cells are predisposed to glucose oxidation in general, it would be great to reduce FFAs whether it's through max carb min fat or pyrucet or something else, so that the cells would experience a less hypoxic environment. Maybe this is why fat people often get hair loss?
