Reversal of hair loss in Mice with “sugar gel”
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I read recently about how in Africa where they didn't have access to skilled surgeons, doctors would pack large open wounds with loads of sugar. It provides a healing and antibacterial environment for the wounds. It's has all kinds of effects on healing the wound site that even mainstream medicine will admit to, while leaving out the bioenergetic component of sugar giving energy to the cells/tissues to help it regenerate.
Ray Peat also mentioned a topical dextrose/sugar solution would be beneficial for the scalp and hair in a podcast with Danny Roddy. I can grab the excerpt if you want, I posted it here somewhere.
So yes, I think if you can deal with the mess of it, like you have a few hours every day where you could leave a solution of dextrose/sugar/honey, it would be very beneficial.
Glad you find that idea of the broad continuum of infection in tissues and hair interesting. I think it is a very possible cause of many if not most cases of hair loss that is too overlooked by people researching hair loss. It's not exactly easy to diagnose if you've got an occult infection of malassezia or some other type of fungus, or an infestation of demodex mites, either or which could be deep in the scalp and missed by a dermatologist/doctor.
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is anyone using a growband?
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@Hearthfire I know that (povidone) iodine is not usually considered Peaty, but I've been having great success with using it to treat ringworm infections on flesh, and toenail fungus. I'm kind of interested to see how it works for my dandruff as well... since that is usually thought of as a yeast infection. I'll have to give it a try and make a small thread for it if the result is good.
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@Rah1woot
I had tried topical iodine (diluted Lugol's) on my scalp before and wouldn't recommend it. I suspect the oxidative action of iodine is bad for hair follicles and the papillae.Although I've read about a peculiar association between those tiny hair muscles (for erecting hairs) and iodide, as in that those erector pilii don't function well in iodide deficiency, and that "disorderly" body or head hair which turns to all directions instead of a generally common alignment may therefore be a hint towards a lack of iodide. IME there's something to it.
Against fungal issues perhaps borax? Don't know for how long the aqueous solution must be allowed to soak in for good effects, though.
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@CrumblingCookie What method of application did you use for the iodine on the scalp?
I've had such great success with using povidone iodine (whose action is a delayed release of iodine) for other fungal infections that I'm still pretty keen to try it on the scalp, to be honest.
I believe what you say about the harm to the follicles, but I would also think it's not a huge deal if used for intermittent treatment, and then washed off.
But this is getting somewhat off the thread topic of sugar gel and hairloss.
I will make a separate thread @CrumblingCookie and tag you.
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I am positive even a small amount of iodine would help if you have a fungal infection in the scalp. How much did you use, CrumblingCookie? Did you notice it drying out your hair or something? If it was a large amount you tried, maybe just mixing in a couple drops with whatever shampoo you use, and increasing until you see negative effects would be the play. Then reduce it a bit.
My brother has been dealing with a ringworm infection on his hand, I'll be recommending he try the iodine. Thanks for that info. Will also try the borax.
@Rah1woot said in Reversal of hair loss in Mice with “sugar gel”:
But this is getting somewhat off the thread topic of sugar gel and hairloss.
I will make a separate thread @CrumblingCookie and tag you.I mean, this thread has evolved into a general discussion of hair loss and treatments already. But maybe it would be good to have a hair loss general so to speak, for easier discoverability for future users.
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I've been pondering on whether to also include D-Biotin in the topical to go along with dexpanthenol.
Wrt to topical apigenin, topical biotin, and topical oleanolic acid (olive tree leaves extract @Mauritio) there's a commercial product with these ingredients called Procapil supposed to induce hair strengthening and anti-hair loss treatment by improving poor scalp micro-circulation, follicle ageing and follicle atrophy. Interestingly, the same company also markets "Apiscalp" to fight dandruff, itching, dryness and hypersoborrhea. It's active ingredient is of course: Apigenin. And caprylic acid (antifungal). That's it. Elegant.
In the Procapil they actually include "biotinoyl tripeptide-1" for biotin, which is"a vitaminized derivative of Tripeptide-1, a matrikine that stimulates hair follicle metabolism and anchoring. It reduces hair loss by inhibiting DHT, improving blood irrigation, and activating hair growth genes [...] stimulating the production of anchoring molecules"*
"Tripeptide-1 (GHK peptide) is a fragment of collagen type I that stimulates collagen and hyaluronic acid synthesis, protects collagen fibers, and scavenges reactive carbonyl species. It helps prevent wrinkles, photo-aging, and DNA damage from pollution and sun exposure."*
Tripeptide-1 is actually synonymous with GHK. It's also synonymous with Prezatide. Peptide-interested people will have read about copper-GHK. I always wondered why I would want such extra copper. It seems the GHK-part itself is effective and can combine with other substances like biotin.
Overall, both topical biotin and topical tripeptide-1 appear interesting.
In an Italian study on short anagen syndrom in children (link), which is a special genetic condition, administration of oral biotin alone drastically improved the anagen:telogen ratio.
But I'm wary of biotin because it impedes the crucial B5-uptake so I'm liking the idea of topical administration (perhaps 0.1% 0.05%?) in combination with dexpanthenol of which the uptake shouldn't be inhibited by biotin. -
Just a quick update: i stoped applying because it was making my hair very dry. I suspect it was the alcohol.
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@Mauritio I like how solban (I make my own) makes my hair feel, very nice
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@Mauritio interesting. Thoughts on diluting with more water?
