Reversal of hair loss in Mice with “sugar gel”
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This is going a little off-topic and I may choose to create a thread dedicated to B5:
@CrumblingCookie said in Reversal of hair loss in Mice with “sugar gel”:
I'm going to drink it from now on at the rate of 2-3g/day.
I've had to decrease that amount in adapation to reality because maximum oral tolerability of DEX seems to be about 100-300mg per time.
More makes the stomach and upper intestines feel a little hard and heavy.
IME it's also more effective when kept in the mouth for a long time before swallowing.
In analogy to many other substances probably more of it stays intact as DEX through sublingual uptake whereas more seems to convert to PA in GI mucosa uptake. I therefore surmise that systemic i.m. DEX injections should be more biologically effective to peripheral tissues than oral intake.@Mauritio
Amidst my search for sourcing injectable dexpantenol from Europe I've stumbled upon an interesting pharmacy product sold in Germany: K5 Spezial-N Tincture. Its ingredients are- Aqua, Isopropyl Alcohol, Benzyl Nicotinate, Panthenol; Salicylic Acid, Tyrosine, Biotin.
Looks to me as if they've been tackling that absorption issue of niacin/niacinamide by grouping it up with benzyl (rather than choosing NMN like you).
That tincture's said to strenthen the scalp, i.e. the roots of the hair and help against diffuse or inflammatory hair loss.
I'd say it needs to be enhanced with glucose and lactate to make for a sound blend and resemble your next candidate. What do you reckon? -
Hi everyone.
This is my new batch:
1.5% Dextrose
1.5% Dexpanthenol
1% L-Lactic Acid
1% Potassiumbicarbonate (to buffer part of the LA to lactate and provide potassium)
0.5%
1%Glycerine (to increase viscosity and skin adhesion of the solution+ emulsification)0.5%
0.8%alpha-Bisabolol (antiinflammatory + antimicrobial + humectant + reductant)0.6% Vitamin E (equals 15mg=22IU per 2.5mL) (needs an extra solubilizer!)
0.4% Allantoin (antiinflammatory + proliferative + keratolytic + humectant)
0.33% L-Threonine (as a source for protein energy + L-Glycine)0.05% Pirocton olamine (antifungal to counteract the topical glucose. This is more of a preemptive measure as I lack the diagnostics to discover or evaluate fungal influences)
0.05% Centella asiatica oil (needs an extra solubilizer!) (for collagen synthesis and inhibit collagen type III fibrosis)
0.002% Apigenin (for HDACi. Equals 5mg per 2.5mL; maybe needs more. If in capsules with fillers: Must be soaked in alcohol first, then filtered, then added. Otherwise the blend will be cloudy and looking "yeasty" and application will leave visible filler particles on the hair)
0.002% Green tea extract powder (50% EGCG) (for HDACi. Use alcoholic filtrate)
0.45% (w/w)
0.5%Rokonsal BSB-N: Benzyl alcohol, glycerine, benzoic acid, sorbic acid (as antibacterial + antifungal preservative)5% Alcohol (Ethanol 96%) (for solubility of pirocton olamin and some mediocre solubility of bisabolol).
-> about pH 4.5
Edit:
I've worked through it again and adjusted the text above. Here's why:| Glycerine 0.5% is enough since 1) the dexpanthenol already provides a good texture, 2) the preservative also contains some glycerine, 3) it's not useful as an emulsifier for any of the ingredients here.
| alpa-Bisabolol is an oil and insoluble in water or glycerine. We need a solubilizer for it or will float on top. Or just bodge it with alcohol in which it is somewhat soluble and leaves a film on top. 0.5% is still very generous as I've seen commercial skincare sera recipes with only 0.1-0.2% bisabolol (racemic).
| Vitamin E oil (natural): This needs a solubilizer if we want to have it pretty. Ethanol disperses just a part of into a milky solution. It still floats on top as small oily droplets.
| Allantoin 0.4% is generous. Probably a reduction to 0.1-0.2% would still be fine. It's fairly water-soluble; up to 0.5%.
| L-Threonine is probably fairly useless here. I'd rather include L-proline and ascorbylpalmitate.
| Centella asiatica oil: Needs a solubilizer like PEG-40 hydr. ricinus oil or something more natural. Otherwise it floats on top.
| Rokonsal only 0.45% (w/w, ie. about 0.4% v/v); a little less because its aqueous solubility threshold is about 0.6%.
| Pirocton olamine (powder) is requires a 1-10% alcohol solution for solubility. It's insoluble in water and glycerine.
| Green tea / EGCG. I've added this to complement the Apigenin.
So, overall it's not the prettiest blend yet because I haven't used solubilizers. I'm a beginner in the world of cosmetics/skincare manufacture. The benzoic/sorbic acid preservative smells slightly almondy-fruity-sweet-alcoholic. One may choose to cover that with other fragrances or use a different preservative.
Will see how it goes with this one. Any thoughts and suggestions?
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I'm late to this thread but has anyone experience of DIM (Diindolylmethane) that can boost catalase in aged Men for reversing white head and beard hair due to the buildup of hydrogen peroxide in the hair follicle leading to oxidative stress and the gradual loss of melanin, causing hair to turn gray or white
Feel free to ignore if you want
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This is all very interesting, and related to recent explorations of mitochondrial function in hair loss.
I wonder if sugar solution could also be useful for wound healing or even phenomena like acne, which is at least sometimes a bacterial infection.
@Hearthfire had written some interesting stuff about the possibility of a broad continuum of infection in tissues and hair. If we think that the spectrum of vitality has a broad range at the subclinical level, that makes a lot of sense.
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I read recently about how in Africa where they didn't have access to skilled surgeons, doctors would pack large open wounds with loads of sugar. It provides a healing and antibacterial environment for the wounds. It's has all kinds of effects on healing the wound site that even mainstream medicine will admit to, while leaving out the bioenergetic component of sugar giving energy to the cells/tissues to help it regenerate.
Ray Peat also mentioned a topical dextrose/sugar solution would be beneficial for the scalp and hair in a podcast with Danny Roddy. I can grab the excerpt if you want, I posted it here somewhere.
So yes, I think if you can deal with the mess of it, like you have a few hours every day where you could leave a solution of dextrose/sugar/honey, it would be very beneficial.
Glad you find that idea of the broad continuum of infection in tissues and hair interesting. I think it is a very possible cause of many if not most cases of hair loss that is too overlooked by people researching hair loss. It's not exactly easy to diagnose if you've got an occult infection of malassezia or some other type of fungus, or an infestation of demodex mites, either or which could be deep in the scalp and missed by a dermatologist/doctor.
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is anyone using a growband?
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@Hearthfire I know that (povidone) iodine is not usually considered Peaty, but I've been having great success with using it to treat ringworm infections on flesh, and toenail fungus. I'm kind of interested to see how it works for my dandruff as well... since that is usually thought of as a yeast infection. I'll have to give it a try and make a small thread for it if the result is good.
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@Rah1woot
I had tried topical iodine (diluted Lugol's) on my scalp before and wouldn't recommend it. I suspect the oxidative action of iodine is bad for hair follicles and the papillae.Although I've read about a peculiar association between those tiny hair muscles (for erecting hairs) and iodide, as in that those erector pilii don't function well in iodide deficiency, and that "disorderly" body or head hair which turns to all directions instead of a generally common alignment may therefore be a hint towards a lack of iodide. IME there's something to it.
Against fungal issues perhaps borax? Don't know for how long the aqueous solution must be allowed to soak in for good effects, though.
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@CrumblingCookie What method of application did you use for the iodine on the scalp?
I've had such great success with using povidone iodine (whose action is a delayed release of iodine) for other fungal infections that I'm still pretty keen to try it on the scalp, to be honest.
I believe what you say about the harm to the follicles, but I would also think it's not a huge deal if used for intermittent treatment, and then washed off.
But this is getting somewhat off the thread topic of sugar gel and hairloss.
I will make a separate thread @CrumblingCookie and tag you.
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I am positive even a small amount of iodine would help if you have a fungal infection in the scalp. How much did you use, CrumblingCookie? Did you notice it drying out your hair or something? If it was a large amount you tried, maybe just mixing in a couple drops with whatever shampoo you use, and increasing until you see negative effects would be the play. Then reduce it a bit.
My brother has been dealing with a ringworm infection on his hand, I'll be recommending he try the iodine. Thanks for that info. Will also try the borax.
@Rah1woot said in Reversal of hair loss in Mice with “sugar gel”:
But this is getting somewhat off the thread topic of sugar gel and hairloss.
I will make a separate thread @CrumblingCookie and tag you.I mean, this thread has evolved into a general discussion of hair loss and treatments already. But maybe it would be good to have a hair loss general so to speak, for easier discoverability for future users.