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    Reversal of hair loss in Mice with “sugar gel”

    Literature Review
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    • H
      Hearthfire @Rah1woot
      last edited by Hearthfire

      @Rah1woot @CrumblingCookie

      I am positive even a small amount of iodine would help if you have a fungal infection in the scalp. How much did you use, CrumblingCookie? Did you notice it drying out your hair or something? If it was a large amount you tried, maybe just mixing in a couple drops with whatever shampoo you use, and increasing until you see negative effects would be the play. Then reduce it a bit.

      My brother has been dealing with a ringworm infection on his hand, I'll be recommending he try the iodine. Thanks for that info. Will also try the borax.

      @Rah1woot said in Reversal of hair loss in Mice with “sugar gel”:

      But this is getting somewhat off the thread topic of sugar gel and hairloss.
      I will make a separate thread @CrumblingCookie and tag you.

      I mean, this thread has evolved into a general discussion of hair loss and treatments already. But maybe it would be good to have a hair loss general so to speak, for easier discoverability for future users.

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      • C
        CrumblingCookie @CrumblingCookie
        last edited by CrumblingCookie

        I've been pondering on whether to also include D-Biotin in the topical to go along with dexpanthenol.
        Wrt to topical apigenin, topical biotin, and topical oleanolic acid (olive tree leaves extract @Mauritio) there's a commercial product with these ingredients called Procapil supposed to induce hair strengthening and anti-hair loss treatment by improving poor scalp micro-circulation, follicle ageing and follicle atrophy. Interestingly, the same company also markets "Apiscalp" to fight dandruff, itching, dryness and hypersoborrhea. It's active ingredient is of course: Apigenin. And caprylic acid (antifungal). That's it. Elegant.
        In the Procapil they actually include "biotinoyl tripeptide-1" for biotin, which is

        "a vitaminized derivative of Tripeptide-1, a matrikine that stimulates hair follicle metabolism and anchoring. It reduces hair loss by inhibiting DHT, improving blood irrigation, and activating hair growth genes [...] stimulating the production of anchoring molecules"*
        "Tripeptide-1 (GHK peptide) is a fragment of collagen type I that stimulates collagen and hyaluronic acid synthesis, protects collagen fibers, and scavenges reactive carbonyl species. It helps prevent wrinkles, photo-aging, and DNA damage from pollution and sun exposure."*

        Tripeptide-1 is actually synonymous with GHK. It's also synonymous with Prezatide. Peptide-interested people will have read about copper-GHK. I always wondered why I would want such extra copper. It seems the GHK-part itself is effective and can combine with other substances like biotin.

        Overall, both topical biotin and topical tripeptide-1 appear interesting.
        In an Italian study on short anagen syndrom in children (link), which is a special genetic condition, administration of oral biotin alone drastically improved the anagen:telogen ratio.
        But I'm wary of biotin because it impedes the crucial B5-uptake so I'm liking the idea of topical administration (perhaps 0.1% 0.05%?) in combination with dexpanthenol of which the uptake shouldn't be inhibited by biotin.

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        • MauritioM
          Mauritio
          last edited by

          Just a quick update: i stoped applying because it was making my hair very dry. I suspect it was the alcohol.

          Dare to think.

          My X:
          x.com/Metabolicmonstr

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          • H
            heyman @Mauritio
            last edited by

            @Mauritio I like how solban (I make my own) makes my hair feel, very nice

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              LetTheRedeemed @Mauritio
              last edited by

              @Mauritio interesting. Thoughts on diluting with more water?

              MauritioM 1 Reply Last reply Reply Quote 0
              • MauritioM
                Mauritio @LetTheRedeemed
                last edited by

                @LetTheRedeemed Well that would take me waiting until all the damaged hair has grown out which would take about 1 year. After which I'm not going to damage my hair for another year by trying out a less strong version.

                Dare to think.

                My X:
                x.com/Metabolicmonstr

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                • W
                  wester130 @Mauritio
                  last edited by

                  has anyone tried tropical pycnogenol ?

                  it can work like minoxidil in its effect for increasing bloodflow and opening up blood vessels

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                  • L
                    LetTheRedeemed @Mauritio
                    last edited by

                    @Mauritio interesting… i personally haven't seen damage.

                    MauritioM 1 Reply Last reply Reply Quote 0
                    • MauritioM
                      Mauritio @LetTheRedeemed
                      last edited by

                      @LetTheRedeemed good for you . Then keep going ! Don't want to discourage anyone. I think I just have sensitive hair.

                      Dare to think.

                      My X:
                      x.com/Metabolicmonstr

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                      • L
                        LetTheRedeemed @Mauritio
                        last edited by

                        @Mauritio if you dont mind my asking, what does the damage look like?

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                        • W
                          wester130 @LetTheRedeemed
                          last edited by wester130

                          results from men who used rosemary oil

                          9a1fef0b-f4c3-4245-9a58-969da1043623-4c49fe77-9226-42db-a66c-e19c89b22590.webp

                          b68816e7-a53e-4bb9-8269-00cea67a4660-71TkuyPXD6L.jpg

                          be2a3033-c8d2-41af-8a90-9aad5fab42a9-713FVvEE3kL.jpg

                          679297bd-5090-4629-9af6-d06e96d1e31d-71o+VIsyl8L.jpg

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                          • L
                            LetTheRedeemed @wester130
                            last edited by

                            @wester130 is there a known mechanism? I've often been cautious of herbalistic remedies that work, as they may be working on the NO pathway...

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                            • H
                              Hearthfire @LetTheRedeemed
                              last edited by

                              @LetTheRedeemed

                              Boosts blood circulation, anti-inflammatory, blocks DHT in the scalp, anti-fungal, anti-microbial, probably effective against parasites like demodex mites.

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                              • W
                                wester130 @LetTheRedeemed
                                last edited by

                                @LetTheRedeemed

                                Carnosic Acid: This compound has antioxidant and anti-inflammatory properties. It improves scalp health by reducing inflammation and oxidative stress, which can contribute to hair loss. It may also stimulate blood circulation to the scalp, enhancing nutrient delivery to hair follicles, promoting growth.
                                Ursolic Acid: This compound is believed to inhibit 5-alpha-reductase, an enzyme that converts testosterone to dihydrotestosterone (DHT).

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