Random, interesting studies
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@Mauritio said in Random, interesting studies:
Papain even lowered visceral fat content slightly below the control group.
It lowered liver enzymes, triglycerides, adipogenic and inflammatory Markers.
It also drastically upregulated AMPK, similarly to aspirin, biotin or infrared light.Nice find. It lowers PPARγ (decreased lipogenesis). By the looks of it increasing CaMKK, LKB1, Sirt1 (which of course are all in reciprocal interaction with AMPK) it probably also works via enhanced degradation of intracellular lipid droplet accumulations, i.e. more lipophagy/autophagy.
Bookmarked for later.Edit: Papain's bound to be biphasic, though, with sub-baseline inhibition past an initial bell curve: Intraarticular injection of papain is how they experimentally induce osteoarthritis and that seems to last beyond immediate enzymatic effects.
And with coronaviruses they describe papain-like proteases being responsible for profound lipophagy/autophagy inhibition.
-> Mechanism of action for the positive findings unclear.
Hormetic stimulation at small doses in healthy animals/tissues/circumstances?
Although the beneficial doses about 10mg/mL (ie c. 1% concentration) in the study above are not particularly small at all? -
fwiw @Mauritio I dont read your twitter stuff because twitter is le gay and doesn't let me scroll properly without an account which requires a phone number and etc etc which is super gehy so maybe you can post ur stuff on a substack or smth idk whatever
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@CrumblingCookie thanks for sharing.
Isn't that because it's a protease, so in sufficient amounts it would digest the protein/cartilage there ?
I think some people report stomach issues when eating too much papaya/papain but only after some time. Maybe it has a similar effect on the intestines.
Viruses need proteases to multiply, so it could have a pro-viral effect ?Also anybody: don't eat the seeds. It's touted as an anti-mircrobial, but it also messes with your hormones . I tried it and didn't feel well for 2 days.
It do like papaya and it seemes to help with constipation/cholestasis.
Next I'll try papain.Dare to think.
My X:
x.com/Metabolicmonstr -
this nigga ate a couple papaya seeds and was ill for two days
reminds me of this quote:
All men have a fire that burns inside of them.
For some it's a fierce flame, the sort that burn 3000kcal a day just by existing.
Men with these flames are the true gigachads, the ones who can enjoy life to the fullest. Everything comes free to them, unlimited energy, great looks, physical prowess, big dicks, charisma, innate skill, vigor, optimism, wealth, opportunity of all kinds etc.
These men are what all men want to be, but sadly most never get to experience such a life.For most men have weak little flames, the ones that burn very frugally. They don't consume much energy which is why they're prone to becoming skinnyfat. Thin little limbs and a big round belly that retains fuel forever since so little is used in a day.
The permanent "survival mode", born out of inner fear. Peasant genetics really. These men will commonly try to better their lives but they find it's a very steep climb. "I'm trying but I just got no energy" they'll say. They're always tired, always feeling ill, always apathetic towards everything.
It's obvious to all bystanders and it instinctively repulses them as lepers do. Women want nothing to do with these hollow husks of men, those who cannot enjoy life.
They're not interested in a smart guy who will live life as efficiently as possible, they want a wild card who isn't afraid of anything. The sort of guy who thinks "New York, sounds like fun!" rather than snorting and citing crime statistics.Basically, the reason why many women like n****rs is because their flames burn a little stronger than the average civilized man's does.
They're not scared of doing what they like, they're going outside and interacting with the world rather than cooping up indoors and observing life from a safe distance. -
@sunsunsun my posts aren't super organized. I post some stuff here, some stuff on X, a lot of stuff on both.
But I was thinking about making a substack, because X users don't seem to be willing to read more than 2 sentences.Dare to think.
My X:
x.com/Metabolicmonstr -
@Mauritio said in Random, interesting studies:
But I was thinking about making a substack, because X users don't seem to be willing to read more than 2 sentences.
Ya, when very interesting, I suggest to give a highlight with max 5 lines. Just to see if it's pertinent for the reader.
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@Mauritio yes I will read ur substack preferably over X and it is a lot easier to look up your articles than searching tweets . I look forward to it
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@sunsunsun said in Random, interesting studies:
They're not scared of doing what they like, they're going outside and interacting with the world rather than cooping up indoors and observing life from a safe distance.
is niggamaxing the new thing!? because wiggers weren't very popular back in the 90s and '00s.
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@Corngold said in Random, interesting studies:
@sunsunsun said in Random, interesting studies:
They're not scared of doing what they like, they're going outside and interacting with the world rather than cooping up indoors and observing life from a safe distance.
is niggamaxing the new thing!? because wiggers weren't very popular back in the 90s and '00s.
@sunsunsun @Corngold jack cruz claimed that one of the main reasons they increased emf exposure that much on population scale, was to get to black people, as blue light was effective to influence white people behaviors but not effective on black due to melanin blocking it, therefore black people were less prone to manipulation, and emf solved it for the most part. All jack cruz claim
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@user2
wow. Sounds legit. -
Decentralised pleb intel.
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@ThinPicking said in Random, interesting studies:
Decentralised pleb intel.
that's the kind of intel I support.
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To anyone that cares: ive just posted my first substack
It's more along the lines of religious symbolism, which I'm really interested as well.Dare to think.
My X:
x.com/Metabolicmonstr -
Do! Will check it out thank you.
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@user2 i think i may believe this
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@Mauritio you did this because i suggested it so can i have 1.3% of the revenue in perpetuity?
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@sunsunsun above one million $, yes.
Dare to think.
My X:
x.com/Metabolicmonstr -
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This subject of papain piqued my interest, as I purchased papaya powder for a homemade toothpaste recipe almost 2 years ago. I basically did a lot of research of various other toothpaste ingredients and I noticed papaya (papain) was in a couple of them. I had never gotten around to making the toothpaste, due to my negative reaction to the MCHA (calcium hydroxyapatite) within the recipe. I thought I might test the papaya powder as a supplement, since I wasn't using it for the toothpaste (for now); but one thing to note is that I see I bought papaya leaves, not papaya fruit. I do see one of the links mentions the leaves, but I wonder if the fruit is more potent or more preferred. I would much prefer to just eat the real fruit, not powder, but since I have the powder I may try it. I'm just thinking out loud here, with my comments. No need to reply unless you guys think there is something worth passing along. Thanks.
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Another way to lower PUFAs effects is to supplement conjugated linoleic acids.
They compete with other PUFAs and do not produce eicosanoids, prostaglandins etc. They actually lower those and get incorporated into cell membranes."Rats treated with CLA isomers showed a reduction in BW, IR, and hypertension. Additionally, there was a significant incorporation of CLA into the plasma membranes of adipocytes and hepatocytes. In contrast, the control rats displayed higher levels of n-6 PUFA and AA in their membranes, which promote the synthesis of eicosanoids and hypertensive prostaglandins."
https://pmc.ncbi.nlm.nih.gov/articles/PMC12584349/An interesting candidate for CLA supplementation is Punicic acid from pomegranate seeds.
https://ift.onlinelibrary.wiley.com/doi/abs/10.1111/1541-4337.12171
