The path to infinite energy and youthfulness

rohmilchbubi

Hi

here is my experimental, fragmented, and unfinished approach to building an advanced pharmacological stack. I will try to update and comment on it continuously. Need feedback.

Some notes beforehand:

This selection of substances should prioritize strong modulators that provide meaningful effects for ones life.
Main intention in all pharmacological experiments is that the resulting effects and side effects must always be life-affirming, life-enhancing, and somehow beneficial to life. Corrections must be made for every undesirable effect.
A strong foundation of health and stability is a prerequisite for experimentation, ensuring safety and effectiveness.
All of this work in progress, i am trying to not attach myself to those and I will throw them overboard if they don't give me what I had hoped for
My risk management allows me also to quickly bounce back from failures
Absolute beginner-level substances are forbidden; every substance should be a strong modulator on its own. It should allow me to reach the next level.
Route of Administration is irrelevant. All needed materials for preparation are available, like millimeter scales, gloves, sterile material, carrier substances, test kits, etc.
Logistics, finances, and legal considerations should not act as limiting factors in experimentation.
This approach should be phenomenological rather than reductionist or biomarker-dependent. These substances should be embodied, experienced, felt, and involved in everyday life, shaping and structuring it.
I don’t care about impersonal universal guidelines, reference values, or standardized norms, which are designed for the masses.
These substances should not antagonize each other but should be additive and work synergistically.
Ranking regarding modulation:
PAM > SAM > Biased Agonist > Partial Agonist > NAM > Full Agonist > Super Agonist > Inverse Agonist > Competitive Antagonist > Non-Competitive Antagonist
(and vice also vice versa if opposite effect is intendend)
Main health markers (needs refinement and thought):
Wakefulness, Infinite Energy, Childhood Remembrance, Childlikeness, Dream Potentiation, Libido, Perceptual Sharpness, Creativity, Playfulness, Sociability, Lightness of Being (mind and body)

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List of targets and substances
Alpha1-adrenergic receptor antagonist- Doxazosin

Alpha2-adrenergic receptor antagonist (day) - Yohimbine
Alpha2-adrenergic receptor agonist (night) - Guanfacine, Clonidine

Beta1,2-adrenergic receptor antagonist (night) - Propranolol
Beta2-adrenergic receptor agonist - Clenbuterol

Adenosine A2A receptor antagonist (day) - Caffeine, KW-6356

cAMP increase - Forskolin, Yohimbine, Caffeine

Pde5-inhibitor - Sildenafil, Tadalafil

AR agonist - Methandienone, Masterolone

D Modulation (DAT Inhibition & D Synthesis) - Bromantane

D1 PAM - ASP-4345
D1 agonist - Sulbutiamine

D2 PAM - MIF-1
D2 agonist (+Prolactine Inhibtion) - Metergoline[2], Cabergoline, Pramipexol
D2 autoreceptor Antagonist - Amisulpride (low dose)

D3 PAM?
D3 agonist - Forskolin, Pramipexol

D4 PAM - MIF-1

Monoamine Transporter Inhibition (DRI + NET + SERT) - Tesofensine

5-HT1A antagonism - Spiroxatrine[1], WAY 100635[1], Metergoline
5-HT1B antagonism - Yohimbine, Metergoline
5-HT1D agonist - Metergoline

5-HT2A agonism? - 2c-b (partial, full? even antagonistic?)
5-HT2A antagonism? - Metergoline

5-HT2B antagonism - Yohimbine

5-HT2C agonism?antagonism? - 2c-b
5-HT2C antagonism? - Metergoline

5-HT3A antagonism (needed?) - Tropisteron, Ondansetron, Mirtazapine

5-HT4A agonism - Usmarapride

5-HT6A antagonism - Rugosa Rose Flower Extract

AMPA PAM - Piracetam, TAK-653

NMDA PAM - Neboglamine
NMDA agonist - D-Aspartic Acid (?)

NMDA receptor antagonist - Ketamine (use case)

Acetylcholesterinase inhibition - Donepezil, Galantamine
a7 nAChR modulator - Tropisteron, Galantamine

M1 receptor PAM - VU319[1]

Trk A,B,C PAM - ACD856

MAO-B Inhibitor - Rasagiline, Selegeline, Safinamide

MAO-A Inhibitor - Moclobemide

H1 receptor agonist - L-Histidine (oder directly stimulates Histamine H2-receptors ?)

H2 Receptor ?

H3 receptor antagonist - Pitolisant, Kutaja bark (Conessine), Betahistine (weak), Ciproxifan

H4 receptor antagonist - Thioperamide
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Other:
Thyroid modulation - T3, T4

Empathy & Sexuality modulation - 5-mapb, 6-apb

General Peptides - Erythropoietin

Uncategorized - 2-fma, Modafinil

Nutrient Density

Mushroom mix (only those which are considered fountain of life in different civilizations)
Dessiccated Oyster
Dessiccated Organs (primary not domesticated animals)

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[1] Not available yet
[2] Even though metergoline have many beneficial targets, it may interfere with 2c-b, which is far more important
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bot-mod

This is insane. But it's so insane it's funny so it's ok.

Norwegian Mugabe

I cheer on the ambitious. That being said, how do you know what to change if something is not working and the protocol is this complex? Your health would likley improve by removing most of this.

caudillofranco

@anib Tremendous ambition... Have you tried eleuthero or other such herbs?

jamezb46

@anib Very interesting stack. I can't imagine anyone actually using all of these simultaneously without ending up in the hospital after a few weeks.

I take it that by "masterolone", you meant "mesterolone" AKA Proviron.

I'm also interested in Bromocriptine for dopamine agonism; I've heard Pramipexole can give people really bad addictions and hard withdrawal.

I also see you make no mention of Racetams in your stack; they can be useful for those with cognitive intensive demands like students. I know according to orthodox RP thinking, increasing choline might not be that great, but the racetams do seem to work for people.

Putting this all into an actually responsible stack that doesn't involve combining "uppers" and "downers" in the same day like Propranolol and Clen in the same day, this is what I would personally think is a template:

Early AM: Caffeine, 2.5 mg Bromocriptine, 25 mg Proviron, TTFD Thiamine

Mid AM: 3 mg Rauwolsine (Yohimbine derivative), 8 mcg T3

Early PM: 100 mg Phenylpiracetam, 25 mg Proviron, Caffeine

Mid PM: 8 mcg T3, B-complex

@jamezb46 xer had piracetam listed

@ThinPicking xD great comment

Kilgore

Talks about infinite energy

Cant even research without chatgpt

Using AI is about the most anti-peat thing ever.

rohmilchbubi

Some answered questions from a crosspost:

"That’s a lot of neurotransmitter modulation. Are you taking these all at once? Or something else? Also, your general framework is fairly flawed in terms of grouping by receptor type, every receptor is expressed in different concentrations in different areas of the body, and interventions can be selective or non-selective. If you’re trying to be systematic about experimentation in this way, you’d need to be more specific about which targets and where you’re actually interacting with. This is especially true for neurotransmitter targets."

The modulation of the mentioned targets has the most significant downstream impact. The effects are real and not just appealing on paper. It took considerable time to filter these, but I believe I have listed almost all the important ones.

Furthermore, the list contains backup targets and molecules in case one does not work as intended. For example, D1 agonism serves as a backup for D1 PAM.

Most substances I have experimented with are not on this list. Some listed substances have already been ruled out but are included as emergency chemicals, such as amisulpride and mirtazapine. A single experiment was sufficient to exclude these due to their undesired effects.

Others require more experimentation, but I have not had the time to continue, or my excitement was too big and the endresults were too disappointing, especially with MAO-B inhibitors. The literature mentions safinamide as non-serotonergic in low dosages, but my experiments (20-40 mg, twice a week) showed the opposite. Even at low doses, it had strong serotonergic effects, disrupting my 2C-B dosing protocol. After approx one month, I had to lower my preferred dose from 8 mg to 2-3 mg (extremely sensitive in 0.2 mg increments). Safinamide made 2C-B too potent and long-lasting, rendering it unusable. Consequently, safinamide is now shelved and will over time degrade.
Alternative experiments with 2.5 mg selegiline yielded no notable effects beyond theoretical benefits, here again, nice on paper, but shitty in reality. Though I may continue experimenting in the future. I tried rasagiline once, but its poor pharmacokinetics make it more suitable for pharmahuasca or other psychedlic experimentation.

In general, my chemical usage patterns are ed, e2d, eod or based on specific situations.

Grouping by receptor type is highly flawed but necessary to give others an idea of what a substance might do. Most people have never heard of ASP-4345, but mentioning that it is dopaminergic, particularly on D1, provides insight into its function. I avoid chemicals with too many targets for obvious reasons, such as cyproheptadine, lisuride, metergoline, and forskolin. I also considered grouping them by goal, like libido enhancement, dream potentiation, or other specific purposes, but this would create redundancies.

I hope that in the future, we might move beyond the current, often meaningless nomenclature of chemicals to a more phenomenological one, capturing the actual subjective experience of using them. For instance, triiodothyronine (T3) is a shitty name - it should be called “IGNITION” because taking 25mcg of t3 feels like being ignited from within, a subtle burning sensation radiating throughout the body, akin to the moment of ignition of the space shuttle SRBs or the turning of the ignition key in an old Group B rally car as its engine roars to life. Such a naming system would provide more intuitive and experiential categorization, making it easier to understand and convey the effects of various substances. But until then…

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"Nice thought experiment. Why do you think you need these interventions? Measured deficiencies, symptoms that don’t seem related to lifestyle errors, etc?"

The need for these interventions arises purely from trial and error, and happy coincidences—moments when everything just clicks. It integrates seamlessly into life, like finding the missing piece of a puzzle.

I no longer do measurements for three reasons:

It no longer holds any meaning for me. The chemical should reveal itself naturally, it should enhance my life, and not serve as compensation for a perceived deficit.
Many claims in modern medicine are questionable, often rooted in flawed paradigms, unreliable reference values, and daily biological fluctuations - not to mention the act of blood collection itself or potential hidden laboratory errors.
Reading some of Harold Hillman’s critical foundational work on various measurement procedures and determination methods has further reinforced my stance. Btw reading Harold Hillmann’s work is an absolute must!

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"It’s your list and you asked for feedback, criticism, etc. So why dbol specifically? What effect are you trying to to achieve? Why an oral? Why choose something that was popular decades ago before better alternatives became available? It suggests a lack of research. That’s why it matters that it is an unusual choice.
Dbol and proviron shouldn’t even be listed in the same functional category. Why would you put them together? What effect are you trying to to achieve with proviron?
If you’re serious, I read this list and your response and think that you’re going to injure yourself."

I have compared different potential AR agonists, and the dynamics and kinetics appealed to me - esp the latter, which aligns more with the natural circadian rhythm compared to the commonly known injections with very long half-lives.

Dbol will serve as my introductory chemical to this topic. I have postponed exploring AR modulation for years, but I believe the time has come. I hope for very positive effects on sexual health, libido, and related aspects. Anabolic effects do not interest me.

My starting protocol is currently 2-3 times a week at 5-10 mg. I am proceeding very slowly, allowing the effects to unfold gradually while carefully observing the outcomes.

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""Sexuality Modulation” sounds something like chemsex? Using recreational drugs is your choice and I’m certainly not judging but if you are using them for longevity purposes that seems a bit of a stretch.
Edit: Ok I see you are just posting all sorts here, not just longevity stuff. Fair enough. Some research chems you have posted don’t have much of a safety profile, but I expect you already know this. I’m just sensitive to this, as I’ve had friends who have ended up in a bad place after experimenting with recreational research chemicals. Be careful with those everybody."

I strongly believe empathogens are longevity molecules, especially those with lower stimulating effects like 5-MAPB. 5-MAPB is one of the most important bonding chemicals. Its primary function is to make one extremely vulnerable and sensitive, opening the space for very deep conversations where both parties listen to each other without judgment. The resulting positive effects on partnership connection have demonstrably life-extending consequences.

rohmilchbubi

@ThinPicking

My main marker for removing a substance is simple: if it doesn't feel right and doesn't integrate properly into my life, it's out.

A prerequisite for any experimentation is being in excellent health. I don't take these substances because I'm sick—it's about play, experimentation, and continuously getting more and more out of the experience.

rohmilchbubi

@Kilgore

No ai (besides the last paragraph). And I don't care about your lord and master Peat.

rohmilchbubi

@Norwegian-Mugabe

Never heard of it. What's your experience with it?

bot-mod

All fine pal it's just an amusingly elaborate concoction if your goal is to get high. I too have been in the "I can cheat the downside" zone before, in another life now. But not quite so complexly.

rohmilchbubi

Well, you’re certainly more of a cowboy than Bryan Johnson, who will probably end up like Howard Hughes, if he lives that long. Out of all your substances, I’ve tried only TAK-653 and didn’t get much out of it. But then it’s mainly an antidepressant and I’m not depressed.

Bryan Johnson is an idiot - but he's not wrong in what he does. He embodies the prime example of what happens when you go into overdrive within the common paradigms, theories, and fantasies of the white-coated consensus of medicine. If you don't ask fundamental questions, you'll end up like him. Most people will do.
One of the many mistakes he has fallen for is the belief that a reduced metabolic rate contributes to longevity. Thus, he proudly boasts about his low basal body temperature, pulse, and blood pressure. However, questioning this assumption leads to the exact opposite conclusion. For further reading on this topic, here is a highly recommended article:
https://vashinvetala.wordpress.com/2016/11/11/bats-bats-bats-and-bioenergetics/

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If you think TAK-653 is just an antidepressant, then you're lacking a basic understanding of humans and chemicals. ie Piracetam is one of the most famous and timeless classic of nootropics, yet it's officially classified as a drug for brain disorders. We don't have brain disorders — so should we avoid it? That's not how it works.

rohmilchbubi

@ThinPicking

What do you mean by "getting high"? I don't smoke pot.

bot-mod

Recommend you read your list back to yourself.

Also good luck with everything buddy

What, and how much, do you eat?

rohmilchbubi

Updated initial post.
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Remarks about Ketamine: Ketamine is the “CLEAVER” - the molecule capable of forcefully yet gently splitting the inner observer from the usual everyday references and associations- the Dasein separates itself from being-in-the-world. It elevates the existentiality of existence, creating a dark, almost ominous, yet never frightening space where thoughts can be free from emotional attachment, where memories come and go. It enables deep reflection and contemplation of matters that would otherwise weigh upon oneself.
Interestingly, at higher doses, there are also visible modulations with closed eyes. Dark cathedral-like structures appear, sometimes vast desert landscapes that one seems to travel past. It is a very peaceful and serene place. Music and tones reach an almost crystal-clear purity, yet one never quite knows where they originate from.
Depending on how one utilizes these thoughts and observations and integrates the results of reflection into their life, this experience can have lasting, life-extending effects. Some also use ketamine for depression and chronic pain, and emerging from those can also be a net benefit for life.
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Divine mushrooms of immortality, the feasts of kings and the gifts of tree spirits:

Chaga
Agaricus Blazei Murrill
Reishi
Shiitake

Ratio 2:1:1:1 (economic and logistic factor), high quality easily obtained and encapsulated

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Combining tadalafil with superoxide-dismutase?

this nigga be k-holin' and waxing poetic

samson

@sushi_is_cringe XD