Peat Approved Anti-Inflammatories?

LetTheRedeemed

Hey guys, could you share any anti-inflammatory substances Peat has suggested? Thanks!

Off the top of my head:
Cyproheptadine
t3
Progesterone

LucH

@LetTheRedeemed said in Peat Approved Anti-Inflammatories?:

could you share any anti-inflammatory substances Peat has suggested? Thanks!

Aspirin but do not take it on continuous take as it has an impact on platelet aggregation.

LetTheRedeemed

@LucH good one. Yeah definitely need vit K with it!!

LucH

@LetTheRedeemed said in Peat Approved Anti-Inflammatories?:

definitely need vit K with it!!

Yes, exactyly what I do.
one drop K2 MK4 ( 1 mg / 1 000 mcg) every day at breakfast (it needs a lot of fat (3 levels for optimizing: 14 - 25 - 36 g fat).
And once a week a mix with K1 1200 - 1500 mcg.

cs3000

@LetTheRedeemed coconut oil
for some reason i noticed it gives me joint pain though but uncommon reaction. similar to what i get from aspirin. apparently its not high in salicylates

its anti inflammatory on cytokines ~10g

LucH

@LetTheRedeemed said in Peat Approved Anti-Inflammatories?:

any anti-inflammatory substances

CO2
useful info on the link
Oral NaHCO3, M2 macrophages, Carbon dioxide and inflammation
https://mirzoune-ciboulette.forumactif.org/t2050-english-corner-oral-nahco3-m2-macrophages-carbon-dioxide-and-inflammation#29755
Target points

Understanding the action of bicarbonate (NaHCO3) on inflammation and immune system (1)
Interaction of macrophages with the redox signals, reprogramming the environment in health and disease: Redox Control of Inflammation by Macrophages (sensing mechanisms), induced by NaHCO3 (2-3)
Protective effects of CO2 on immunosuppressive system, mediated by the splenic nerve (new anti-inflammatory pathway), with the help of the chemical messenger acetylcholine (4)
Carbon dioxide has antioxidant effects, and many other stabilizing actions. (5)

LetTheRedeemed

@cs3000 awesome

LetTheRedeemed

@LucH

16charactersitis

@LetTheRedeemed
ray peat mentioned anti inflammatory substances:
sugar, aspirin, progesterone, lidocaine and food sources of magnesium and calcium, eg, eggs, dairy, coffee and leafy greens (eg spinach)

LetTheRedeemed

@16charactersitis great, thanks!

Luke

Naringenin and Naringin, so orange/tangerine/clementine juice, orange marmalade, citrus fruits in general.

LucH

@16charactersitis said in Peat Approved Anti-Inflammatories?:

sugar, aspirin, progesterone, lidocaine and food sources of magnesium and calcium, eg, eggs, dairy, coffee and leafy greens (eg spinach)

OK but it needs to be modulated. Listen to your body!
Sugar as long it comes with fiber, 50/50 glucose / fructose, it doesn't stimulate insulin too high, comes with cofactors to burn well...
Not everybody is able to burn a high level sugar when drinking 200 ml (7 oz) OJ after cereals and 240 ml milk (8.5 oz.). Limit OJ to 100 ml (3.5 oz.) if your BMI is over 25. and don't eat a yaourt as dessert. Take it apart (collation).

Calcium as long you target it well. Too low and it will excite PTH, too high (what we don't need) and it will unbalance Ca/ Mg ratio. Ca only from food or it will prevent us from assimilating Zn Fe Cu (same transport).
10-20 % people suffer from a high level of intolerance to WGA (gluten) and need to recover during the night. Already heard from cross-reaction? 50 % people intolerant to wga also suffer from casein intolerance (80 % milk proteins). Not every body has the capacity to digest a high level of lactose (amount of lactase enzyme limited).

RP is right but it must be contextualized, as long you listen to your body reaction.

And by the way, not everybody can get A2 milk, directly from the farmer. A1 and A2 milk contain different types of beta-casein protein.

Eggs as long you balance leucine with glycine (from beef cuts or bone both e.g.). Leucine stimulates growth. A full spectrum of amino acids is required to avoid cell anarchy (cancer).
2 to 3 times a week to avoid leucocytose. If you overdrive, it will give histaminose, a stress reaction.

Leafy greens as long your vary. Fine, so. Spinach is very high in oxalate (660 mg). I don't take spinach without eating cheese.
4/1 ratio Ca / Ox is fine. 4/3 if not every day and you didn't already get problems with lithiasis.
Or bring potassium citrate (Mg bisglycinate 2.5 g is fine too) to amalgam excess oxalate. Lithiasis prevention (kidney stones). RDA is 50 mg Ox. Do not take more 150-200 mg oxalate (highest level) without "diluting" it, on a repeated way. 1200 mg Ca/d will mostly do the job well, when eating spinach or rhubarb, for most people, if you vary well.

DavidPS

I only just noticed this thread.

Peatbot.com: Based on the provided context, some safe anti-inflammatory substances and supplements include:

Aspirin: Known for its anti-inflammatory properties and ability to potentiate the deacetylation of histones.
Magnesium: Helps stabilize mast cells and reduce the release of histamine, which promotes inflammation.
Caffeine: Found in coffee and chocolate, it has anti-inflammatory and liver-protective effects.
Coconut Oil: Contains saturated fatty acids that inhibit histamine formation and protect the liver from endotoxin.
Progesterone and Testosterone: These hormones protect against histamine.
Benadryl (Diphenhydramine): Protects the liver and other organs from toxins and the effects of histamine.
Thyroid Hormone: Known for its anti-inflammatory function, especially in arthritis and rheumatic conditions.
Carbon Dioxide (CO2): Described as a basic anti-inflammatory substance.
Methylene Blue: Effective in small doses as an anti-inflammatory agent.
Saturated Fats: Found in foods like coconut oil, they have protective, anti-inflammatory effects.

These substances are noted for their anti-inflammatory properties and are considered safe when used appropriately. However, it's important to consult with a healthcare provider before starting any new supplement regimen.

LetTheRedeemed

@DavidPS

LucH

@DavidPS said in Peat Approved Anti-Inflammatories?:

Caffeine: Found in coffee and chocolate, it has anti-inflammatory and liver-protective effects.

One example to say we should take the context into account.
Caffeine and coffee are fine, at least for 40 % people, as long you drink 3-5 cups (120 ml) a day.
Shortly said: Caffeine leaves metabolites that the liver is going to degrade / demethylate.
However, only 40 % people can manage it well (gene MTFR)

In adults, caffeine is almost completely metabolized in the liver by oxidation, demethylation, and acetylation. However, there are tiny genetic variations in 60% of individuals that can alter the breakdown of xanthines. In about 40% of the population, it is extremely efficient, so that caffeine is destroyed very quickly, before it causes side effects. Each person's sensitivity also depends on the number of caffeine receptors we have in our brain, which, again, depends on our genetics. Moreover, in people who drink coffee all day, the body protects itself by reducing the number of receptors, which reduces sensitivity to caffeine. Similar to a phenomenon of habituation. (1)
Caffeine is a methyl and is metabolized in the liver (CYP1A2 enzyme), then partially degraded. Caffeine is demethylated, then transformed into 3 primary metabolites: Paraxanthine (84%), theobromine (12%), and theophylline (4%). (2)
If you brake the way out of the kidneys by some molecules (e.g. polyphenols as coumarin from grapefruit juice or curcumin as anti-inflammatory, without making staples), it could exacerbate some side-effects you could have well managed if you had moderated the takes.

So, in short, no problem if you listen to your body signs and you manage it well.
I do appreciate coffee (espresso and perco) but I know I have to avoid habituation (4-5 hours between 2 cups), I have to take it easy from time to time when the anxiety level rises or when I suffer from excess histamine.
So finally, adapt and feel free to do it your own way. Moderate if you cumulate with oxalates and phytates. Caffeine could be considered as a friend or a foe, according to the context. (3)

References

https://nhco-nutrition.com/journal/pourquoi-la-cafeine-na-pas-le-meme-effet-chez-tout-le-monde/
Source : Guide des compléments alimentaires pour sportifs, Michael Gundill et Frederic Delavier, Ed Vigot.
https://doi.org/10.1016/j.nutres.2020.05.005
« Effets de la caféine sur le métabolisme systémique, les voies oxydatives-inflammatoires et les performances physiques ».
Caféine, ami ou ennemi ? (Friend or foe ?)
http://mirzoune-ciboulette.forumactif.org/t1523-cafeine-ami-ou-ennemi#17789

DavidPS

@LucH - Thanks for all of the information.

A landmark umbrella review of 201 observational studies found that coffee intake was associated with:

17% reduced risk of all-cause mortality
19% reduced risk of cardiovascular disease-related death
15% reduced risk of cardiovascular disease
18% lower risk of developing cancer
30% reduced risk of type 2 diabetes
36% reduced risk of Parkinson’s disease

The study can’t claim causation, but the consistency of results and impressive effect sizes are encouraging.

Oh, and the biggest effects were seen at 3-4 cups per day.

Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes (2017)
I like the visual display of information in the study.

DavidPS

The connection between coffee, Lawsonibacter, quinic acid, and other microbe-derived metabolites could be how coffee might be exerting its beneficial effects.

Coffee consumption is associated with intestinal Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts (2024)