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    Epitestosterone, premature balding, and "male PCOS"

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    • R
      risingfire @saturnuscv
      last edited by

      @saturnuscv thank you

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      • B
        basednigga2006
        last edited by basednigga2006

        Interesting papers

        https://link.springer.com/article/10.1007/s13555-022-00799-7

        https://www.sciencedirect.com/science/article/pii/S1578219010706247?ref=pdf_download&fr=RR-2&rr=860df7025e458b43

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        • GastonG
          Gaston
          last edited by

          Supposedly you can increase epitestosterone by topically applying 7-keto-DHEA. I doubt applying it to the scalp would do anything, but if I can get the 7-keto-DHEA to dissolve, I'll put some on my scalp and on my navel/stomach and see what happens.

          S I MauritioM 3 Replies Last reply Reply Quote 0
          • S
            saturnuscv @Gaston
            last edited by saturnuscv

            @Gaston do keep us updated on that. I want to try 7kDHEA but I don’t want to make anything worse.

            My hair is not too bad at the moment but since stopping progesterone I have been shedding more than usual. I’m close to just giving up on exogenous steroids and thyroid+cholesterol+bloomaxxing because every time I introduce some kind to steroid it either greatly aggravates shedding (Pansterone) or makes me feel and look like shite (Cortinon)

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            • I
              Insr @Gaston
              last edited by

              Thanks for those papers! 57% of those who are already bald by age 45 have metabolic syndrome compared to 14% of non-bald 43 year olds. That's an impressive result.

              @Gaston said in Epitestosterone, premature balding, and "male PCOS":

              Supposedly you can increase epitestosterone by topically applying 7-keto-DHEA. I doubt applying it to the scalp would do anything, but if I can get the 7-keto-DHEA to dissolve, I'll put some on my scalp and on my navel/stomach and see what happens.

              Interesting! Where did you find that out? I couldn't find anything about it.

              GastonG 1 Reply Last reply Reply Quote 0
              • GastonG
                Gaston @Insr
                last edited by

                @insufferable

                https://www.degruyter.com/document/doi/10.1515/CCLM.2005.038/html

                I came across it in one of Hans' articles.

                https://testonation.com/2022/01/17/7-keto-dhea-what-you-need-to-know-fat-loss-thyroid-androgens-etc/

                I 1 Reply Last reply Reply Quote 0
                • I
                  Insr @Gaston
                  last edited by

                  @Gaston Awesome, thank you! That's the first place I've seen any mention of an epiT increase.

                  ~12% testosterone decrease, ~80% epitestosterone increase.

                  I know nothing about 7-keto-DHEA. Do you have any idea why it would do that?

                  GastonG 1 Reply Last reply Reply Quote 0
                  • GastonG
                    Gaston @Insr
                    last edited by

                    @insufferable
                    I can't say that I understand the mechanism, no. But that's not going to stop me from recklessly experimenting!

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                    • MauritioM
                      Mauritio @Gaston
                      last edited by

                      @Gaston You might be on to something.
                      I remember when taking 7ketoDHEA my hairloss was decreased. It is pretty safe to experiment with.

                      it is not water soluble though.

                      "7 Keto DHEA (Dehydroepiandrosterone) is a white crystalline powder. It is very soluble in warm methanol, soluble in ethanol, and not soluble in water. Micronized so that 90% of particles are less than 20 μm."

                      Dare to think.

                      My X:
                      x.com/Metabolicmonstr

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                      • MauritioM
                        Mauritio
                        last edited by

                        I am going to try to dissolve a few mg of 7ketoDHEA in alcohol and apply it to my scalp.

                        Dare to think.

                        My X:
                        x.com/Metabolicmonstr

                        GastonG 1 Reply Last reply Reply Quote 0
                        • MauritioM
                          Mauritio
                          last edited by

                          The whole section under anti-andrigenic activity really doesnt sound good...

                          But if it is only locally in the scalp, it might be ok.

                          The difference of epitestosterone in the scalp between balding and non-balding fasthers is huge. Non-balding fathers have an almost 6 times lower Testosterone/ epitestosterone ratio in the scalp.

                          Dare to think.

                          My X:
                          x.com/Metabolicmonstr

                          1 Reply Last reply Reply Quote 0
                          • GastonG
                            Gaston @Mauritio
                            last edited by

                            @Mauritio

                            This is how I attempted to dissolve the powder:

                            7-Keto-DHEA
                            300mg powder
                            1/2 oz. dropper bottle
                            ~15% isopropyl myristate (I don't think this is necessary, but I had some left over from dissolving DHEA powder)
                            ~80% ethanol
                            (~5% powder)
                            ~300 drops
                            ~1mg per drop

                            It didn't fully dissolve, but that's because there are excipients in the capsule like silicon dioxide and magnesium stearate. I don't think that there exists a commercially available source of pure 7-Keto-DHEA powder.

                            When I apply 10mg to my navel I get sleepy as heck, but that could also be because I'm laying down when I do it lol

                            S W 2 Replies Last reply Reply Quote 0
                            • S
                              saturnuscv @Gaston
                              last edited by

                              @Gaston it’s anti-cortisol and doesn’t supply a substrate to make estrogen so feeling sleepy is not unusual.

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                              • W
                                wester130 @Insr
                                last edited by

                                @insufferable and how to cure PCOS?

                                Inositol??

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                                • W
                                  wester130 @Gaston
                                  last edited by wester130

                                  @Gaston

                                  it won't work topically??

                                  Effects of transdermal application of 7-oxo-DHEA on the levels of steroid hormones, gonadotropins and lipids in healthy men.
                                  Sulcová J1, Hill M, Masek Z, Ceska R, Novácek A, Hampl R, Stárka L.
                                  https://www.ncbi.nlm.nih.gov/pubmed/11300231

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                                  • W wester130 referenced this topic on
                                  • W
                                    wester130 @saturnuscv
                                    last edited by

                                    @saturnuscv I now think men could try licorice, vitex and spearmint and schisandra

                                    https://pmc.ncbi.nlm.nih.gov/articles/PMC8140208/

                                    testosterone is "bad" when it is out of control

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                                    • W
                                      wester130 @Insr
                                      last edited by wester130

                                      @Insr

                                      https://pubmed.ncbi.nlm.nih.gov/16462145/

                                      licorice reduced dhea-s

                                      stinging nettles reduced cortisol too

                                      https://pmc.ncbi.nlm.nih.gov/articles/PMC8959287/

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