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    Epitestosterone, premature balding, and "male PCOS"

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    • I
      Insr @Gaston
      last edited by

      Thanks for those papers! 57% of those who are already bald by age 45 have metabolic syndrome compared to 14% of non-bald 43 year olds. That's an impressive result.

      @Gaston said in Epitestosterone, premature balding, and "male PCOS":

      Supposedly you can increase epitestosterone by topically applying 7-keto-DHEA. I doubt applying it to the scalp would do anything, but if I can get the 7-keto-DHEA to dissolve, I'll put some on my scalp and on my navel/stomach and see what happens.

      Interesting! Where did you find that out? I couldn't find anything about it.

      GastonG 1 Reply Last reply Reply Quote 0
      • GastonG
        Gaston @Insr
        last edited by

        @insufferable

        https://www.degruyter.com/document/doi/10.1515/CCLM.2005.038/html

        I came across it in one of Hans' articles.

        https://testonation.com/2022/01/17/7-keto-dhea-what-you-need-to-know-fat-loss-thyroid-androgens-etc/

        I 1 Reply Last reply Reply Quote 0
        • I
          Insr @Gaston
          last edited by

          @Gaston Awesome, thank you! That's the first place I've seen any mention of an epiT increase.

          ~12% testosterone decrease, ~80% epitestosterone increase.

          I know nothing about 7-keto-DHEA. Do you have any idea why it would do that?

          GastonG 1 Reply Last reply Reply Quote 0
          • GastonG
            Gaston @Insr
            last edited by

            @insufferable
            I can't say that I understand the mechanism, no. But that's not going to stop me from recklessly experimenting!

            1 Reply Last reply Reply Quote 0
            • MauritioM
              Mauritio @Gaston
              last edited by

              @Gaston You might be on to something.
              I remember when taking 7ketoDHEA my hairloss was decreased. It is pretty safe to experiment with.

              it is not water soluble though.

              "7 Keto DHEA (Dehydroepiandrosterone) is a white crystalline powder. It is very soluble in warm methanol, soluble in ethanol, and not soluble in water. Micronized so that 90% of particles are less than 20 μm."

              Dare to think.

              My X:
              x.com/Metabolicmonstr

              1 Reply Last reply Reply Quote 0
              • MauritioM
                Mauritio
                last edited by

                I am going to try to dissolve a few mg of 7ketoDHEA in alcohol and apply it to my scalp.

                Dare to think.

                My X:
                x.com/Metabolicmonstr

                GastonG 1 Reply Last reply Reply Quote 0
                • MauritioM
                  Mauritio
                  last edited by

                  The whole section under anti-andrigenic activity really doesnt sound good...

                  But if it is only locally in the scalp, it might be ok.

                  The difference of epitestosterone in the scalp between balding and non-balding fasthers is huge. Non-balding fathers have an almost 6 times lower Testosterone/ epitestosterone ratio in the scalp.

                  Dare to think.

                  My X:
                  x.com/Metabolicmonstr

                  1 Reply Last reply Reply Quote 0
                  • GastonG
                    Gaston @Mauritio
                    last edited by

                    @Mauritio

                    This is how I attempted to dissolve the powder:

                    7-Keto-DHEA
                    300mg powder
                    1/2 oz. dropper bottle
                    ~15% isopropyl myristate (I don't think this is necessary, but I had some left over from dissolving DHEA powder)
                    ~80% ethanol
                    (~5% powder)
                    ~300 drops
                    ~1mg per drop

                    It didn't fully dissolve, but that's because there are excipients in the capsule like silicon dioxide and magnesium stearate. I don't think that there exists a commercially available source of pure 7-Keto-DHEA powder.

                    When I apply 10mg to my navel I get sleepy as heck, but that could also be because I'm laying down when I do it lol

                    S W 2 Replies Last reply Reply Quote 0
                    • S
                      saturnuscv @Gaston
                      last edited by

                      @Gaston it’s anti-cortisol and doesn’t supply a substrate to make estrogen so feeling sleepy is not unusual.

                      W 1 Reply Last reply Reply Quote 0
                      • W
                        wester130 @Insr
                        last edited by

                        @insufferable and how to cure PCOS?

                        Inositol??

                        1 Reply Last reply Reply Quote 0
                        • W
                          wester130 @Gaston
                          last edited by wester130

                          @Gaston

                          it won't work topically??

                          Effects of transdermal application of 7-oxo-DHEA on the levels of steroid hormones, gonadotropins and lipids in healthy men.
                          Sulcová J1, Hill M, Masek Z, Ceska R, Novácek A, Hampl R, Stárka L.
                          https://www.ncbi.nlm.nih.gov/pubmed/11300231

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                          • W wester130 referenced this topic on
                          • W
                            wester130 @saturnuscv
                            last edited by

                            @saturnuscv I now think men could try licorice, vitex and spearmint and schisandra

                            https://pmc.ncbi.nlm.nih.gov/articles/PMC8140208/

                            testosterone is "bad" when it is out of control

                            1 Reply Last reply Reply Quote 0
                            • W
                              wester130 @Insr
                              last edited by wester130

                              @Insr

                              https://pubmed.ncbi.nlm.nih.gov/16462145/

                              licorice reduced dhea-s

                              stinging nettles reduced cortisol too

                              https://pmc.ncbi.nlm.nih.gov/articles/PMC8959287/

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