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    Epitestosterone, premature balding, and "male PCOS"

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    • I
      Insr @Gaston
      last edited by

      @Gaston Awesome, thank you! That's the first place I've seen any mention of an epiT increase.

      ~12% testosterone decrease, ~80% epitestosterone increase.

      I know nothing about 7-keto-DHEA. Do you have any idea why it would do that?

      GastonG 1 Reply Last reply Reply Quote 0
      • GastonG
        Gaston @Insr
        last edited by

        @insufferable
        I can't say that I understand the mechanism, no. But that's not going to stop me from recklessly experimenting!

        1 Reply Last reply Reply Quote 0
        • MauritioM
          Mauritio @Gaston
          last edited by

          @Gaston You might be on to something.
          I remember when taking 7ketoDHEA my hairloss was decreased. It is pretty safe to experiment with.

          it is not water soluble though.

          "7 Keto DHEA (Dehydroepiandrosterone) is a white crystalline powder. It is very soluble in warm methanol, soluble in ethanol, and not soluble in water. Micronized so that 90% of particles are less than 20 μm."

          Dare to think.

          My X:
          x.com/Metabolicmonstr

          1 Reply Last reply Reply Quote 0
          • MauritioM
            Mauritio
            last edited by

            I am going to try to dissolve a few mg of 7ketoDHEA in alcohol and apply it to my scalp.

            Dare to think.

            My X:
            x.com/Metabolicmonstr

            GastonG 1 Reply Last reply Reply Quote 0
            • MauritioM
              Mauritio
              last edited by

              The whole section under anti-andrigenic activity really doesnt sound good...

              But if it is only locally in the scalp, it might be ok.

              The difference of epitestosterone in the scalp between balding and non-balding fasthers is huge. Non-balding fathers have an almost 6 times lower Testosterone/ epitestosterone ratio in the scalp.

              Dare to think.

              My X:
              x.com/Metabolicmonstr

              1 Reply Last reply Reply Quote 0
              • GastonG
                Gaston @Mauritio
                last edited by

                @Mauritio

                This is how I attempted to dissolve the powder:

                7-Keto-DHEA
                300mg powder
                1/2 oz. dropper bottle
                ~15% isopropyl myristate (I don't think this is necessary, but I had some left over from dissolving DHEA powder)
                ~80% ethanol
                (~5% powder)
                ~300 drops
                ~1mg per drop

                It didn't fully dissolve, but that's because there are excipients in the capsule like silicon dioxide and magnesium stearate. I don't think that there exists a commercially available source of pure 7-Keto-DHEA powder.

                When I apply 10mg to my navel I get sleepy as heck, but that could also be because I'm laying down when I do it lol

                S W 2 Replies Last reply Reply Quote 0
                • S
                  saturnuscv @Gaston
                  last edited by

                  @Gaston it’s anti-cortisol and doesn’t supply a substrate to make estrogen so feeling sleepy is not unusual.

                  W 1 Reply Last reply Reply Quote 0
                  • W
                    wester130 @Insr
                    last edited by

                    @insufferable and how to cure PCOS?

                    Inositol??

                    1 Reply Last reply Reply Quote 0
                    • W
                      wester130 @Gaston
                      last edited by wester130

                      @Gaston

                      it won't work topically??

                      Effects of transdermal application of 7-oxo-DHEA on the levels of steroid hormones, gonadotropins and lipids in healthy men.
                      Sulcová J1, Hill M, Masek Z, Ceska R, Novácek A, Hampl R, Stárka L.
                      https://www.ncbi.nlm.nih.gov/pubmed/11300231

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                      • W wester130 referenced this topic on
                      • W
                        wester130 @saturnuscv
                        last edited by

                        @saturnuscv I now think men could try licorice, vitex and spearmint and schisandra

                        https://pmc.ncbi.nlm.nih.gov/articles/PMC8140208/

                        testosterone is "bad" when it is out of control

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                        • W
                          wester130 @Insr
                          last edited by wester130

                          @Insr

                          https://pubmed.ncbi.nlm.nih.gov/16462145/

                          licorice reduced dhea-s

                          stinging nettles reduced cortisol too

                          https://pmc.ncbi.nlm.nih.gov/articles/PMC8959287/

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