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Epitestosterone, premature balding, and "male PCOS"

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  • G
    Gaston @Insr
    last edited by Mar 9, 2024, 9:42 PM

    @insufferable
    I can't say that I understand the mechanism, no. But that's not going to stop me from recklessly experimenting!

    1 Reply Last reply Reply Quote 0
    • M
      Mauritio @Gaston
      last edited by Mar 10, 2024, 11:03 AM

      @Gaston You might be on to something.
      I remember when taking 7ketoDHEA my hairloss was decreased. It is pretty safe to experiment with.

      it is not water soluble though.

      "7 Keto DHEA (Dehydroepiandrosterone) is a white crystalline powder. It is very soluble in warm methanol, soluble in ethanol, and not soluble in water. Micronized so that 90% of particles are less than 20 μm."

      Dare to think.

      My X:
      x.com/Metabolicmonstr

      1 Reply Last reply Reply Quote 0
      • M
        Mauritio
        last edited by Mar 10, 2024, 3:46 PM

        I am going to try to dissolve a few mg of 7ketoDHEA in alcohol and apply it to my scalp.

        Dare to think.

        My X:
        x.com/Metabolicmonstr

        G 1 Reply Last reply Mar 10, 2024, 9:09 PM Reply Quote 0
        • M
          Mauritio
          last edited by Mar 10, 2024, 3:57 PM

          The whole section under anti-andrigenic activity really doesnt sound good...

          But if it is only locally in the scalp, it might be ok.

          The difference of epitestosterone in the scalp between balding and non-balding fasthers is huge. Non-balding fathers have an almost 6 times lower Testosterone/ epitestosterone ratio in the scalp.

          Dare to think.

          My X:
          x.com/Metabolicmonstr

          1 Reply Last reply Reply Quote 0
          • G
            Gaston @Mauritio
            last edited by Mar 10, 2024, 9:09 PM

            @Mauritio

            This is how I attempted to dissolve the powder:

            7-Keto-DHEA
            300mg powder
            1/2 oz. dropper bottle
            ~15% isopropyl myristate (I don't think this is necessary, but I had some left over from dissolving DHEA powder)
            ~80% ethanol
            (~5% powder)
            ~300 drops
            ~1mg per drop

            It didn't fully dissolve, but that's because there are excipients in the capsule like silicon dioxide and magnesium stearate. I don't think that there exists a commercially available source of pure 7-Keto-DHEA powder.

            When I apply 10mg to my navel I get sleepy as heck, but that could also be because I'm laying down when I do it lol

            S W 2 Replies Last reply Mar 11, 2024, 7:50 AM Reply Quote 0
            • S
              saturnuscv @Gaston
              last edited by Mar 11, 2024, 7:50 AM

              @Gaston it’s anti-cortisol and doesn’t supply a substrate to make estrogen so feeling sleepy is not unusual.

              W 1 Reply Last reply Mar 4, 2025, 7:48 PM Reply Quote 0
              • W
                wester130 @Insr
                last edited by Jun 20, 2024, 6:34 PM

                @insufferable and how to cure PCOS?

                Inositol??

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                • W
                  wester130 @Gaston
                  last edited by wester130 Jul 7, 2024, 4:54 PM Jul 7, 2024, 4:42 PM

                  @Gaston

                  it won't work topically??

                  Effects of transdermal application of 7-oxo-DHEA on the levels of steroid hormones, gonadotropins and lipids in healthy men.
                  Sulcová J1, Hill M, Masek Z, Ceska R, Novácek A, Hampl R, Stárka L.
                  https://www.ncbi.nlm.nih.gov/pubmed/11300231

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                  • W wester130 referenced this topic on Jul 17, 2024, 8:00 AM
                  • W
                    wester130 @saturnuscv
                    last edited by Mar 4, 2025, 7:48 PM

                    @saturnuscv I now think men could try licorice, vitex and spearmint and schisandra

                    https://pmc.ncbi.nlm.nih.gov/articles/PMC8140208/

                    testosterone is "bad" when it is out of control

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                    • W
                      wester130 @Insr
                      last edited by wester130 Mar 9, 2025, 11:41 PM Mar 9, 2025, 11:15 PM

                      @Insr

                      https://pubmed.ncbi.nlm.nih.gov/16462145/

                      licorice reduced dhea-s

                      stinging nettles reduced cortisol too

                      https://pmc.ncbi.nlm.nih.gov/articles/PMC8959287/

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