@Fructose got my labs:

Creatinin is high because I am significantly muscular and I take creatine.

EGFR CKD-EPI, urea and uric acid are fine.
Liver has also no problems.

In love with Aspirin.

@Quantification yes, you are right. But I want to lose fat right now. When the fat is lost, I will go back to normal.

@DaveFoster I am 102 kg. I think this one
also matters, no?

@onliest if you find a source, please let me know

@JosipBrozTayto said in Uncoupling with 4g Aspirin:

@SeroBass

@SeroBass said in Uncoupling with 4g Aspirin:

I am 104kg, 178cm and ca. 20% bodyfat (I am doing Mentzer style bodybuilding). My goal is (of course) to lose fat.

Literally me. Try cutting fat and replacing with more carbs for a few months. High Carb Low fat is currently the only thing that is working to lower my bodyfat.

Yeah, going well so far. I also do a lot of low intensity cardio to do fatmaxx. It is working. The peaty way to loose weight!

@Hitler said in Uncoupling with 4g Aspirin:

I would be weary about taking large Aspirin doses consistently. I was taking ~3 grams a day for a week once and I was fine, but I'm not sure if is preferable or sustainable to do.

I am at month nr. 2 now. Probably I need to do some blood work...

@Fructose said in Uncoupling with 4g Aspirin:

@SeroBass
So yes. Indeed, large doses of aspirin are capable of causing nephrotoxicity. A reduction in prostaglandins may reduce renal blood flow and cause impaired glomerular filtration. I think this is due to improper reabsorption of minerals and electrolytes. Adequate hydration may help prevent renal complications and renal tubular apoptosis. Most clinical cases of aspirin-related kidney damage involved large doses taken "all at once." They were also probably not adequately hydrated.

Vitamin K2 may alleviate the side effects of aspirin, because it has been proven that it can work against vasoconstriction of blood vessels, which is the main cause of damage to kidney tissue after aspirin.

All right. So meaning that enough OJ, water, milk and little bit of salt will counter the toxicity. Neverthless, I need to go to the doc and do some blood work to check my urat and stuff. Thank you.

@toiletking said in Uncoupling with 4g Aspirin:

@SeroBass what's the point though. You wanna find out whether it's toxic or what?

Uncoupling mitochondria --> leaning down/burning fat depots, increasing CO2 etc.

@alpine-raspberry Sounds like you are Swiss, German or Austrian?
I get my raw milk from the nature shops (local health shop). I always buy the brand "Demeter Rohmilch". It tastes best and my gut has no problems with it.
Only issue: 3.90 Swiss Francs per liter.

I saw those cows with my own eyes in Zürich. They have better live than me

@Evolutionarily according to Ray, 3 flat teaspoons a day is enough

@raypneat This is a nice one. Coconut oil is underrated. The MCT fats are also uncoupling mitochondria. That's why you get a warm feeling when eating it.