Posts made by Appa

@questforhealth It looks like a noradrenaline response from the liver flush.

Have you tried high dose glycine by any chance?

Improve your thyroid and dopaminergic tone and you will see how hungry you will be.

Cyproheptadine with weed is great short term but will increase your prolactin in the long run.

You will have better results with Thiamine, as well as nutrients improving the conversion of T4 to T3, especially Selenium as well as some bioavailable Magnesium to compensate for the overstimulation of the two. They are very affordable and are extremly good at improving overall energy levels, the more energy levels you have, the better your digestion and appetite will be.

Either by upregulating the enzyme using Forskolin or Tyrosine, using a D2 partial agonist, or an NMDA antagonist like memantine, or all three at the same time.

Take a look at this article by Hans : https://testonation.com/2020/06/26/the-high-acetylcholine-syndrome/

I've struggled with this problem for a long time and it made me intolerant to Thiamine even if my body needed it as it was the only supplement that was improving my energy and breathing but was giving me severe anxiety.

I even had a post on the RPF where I tried a lot of different things from Benadryl, Scopolamine, Forskolin, I couldn't update it because I didn't have the right anymore to post in the forum.

Anti-cholinergics like Cyproheptadine, Diphenhydramine or Scopolamine are great at improving symptoms short term, Forskolin is better for mid-term, but in the long run, you got to fix the acetylcholine system, it's not a problem of high or low acetylcholine, it's mainly why the body doesn't use it properly.

Thiamine will improve your acetylcholine status but only temporary, a combination of Thiamine and an NMDA antagonist like magnesium L-Threonate, memantine or agmatine will fix it long term. At least, it's what it did for me after trying hundreds of supplements and medications.

I'd say love and a good laugh

I tried TTFD, Sulbutiamine, Benfotiamine and Thiamine HCL

They all share the improvment in physical energy and improved breathing in my opinion.

Benfotiamine was more effective for peripheral neuropathy.

TTFD feels very psychedelic and is in my opinion the best form for intellectual tasks but it comes with a lot of side effects compared to the other forms.

Sulbutiamine feels very physical, it's my favorite form because of the physical kick in the ass effect it provides.

Overall they are all good at increasing levels of thiamine.

TTFD is better when the goal is to increase central nervous system levels of thiamine.

Benfotiamine for neuronal pain, it was the only form that was aleviating my headaches and tingling in extremities.

Sulbutiamine is great for physically demanding tasks.

Thiamine HCL is doing a little bit of each one and requires higher doses compared to the other forms.

@Cristiano said in Women, and Why Men are the Problem:

@AltarandThrone I am happy to be the first one to say that this is a weird bellyaching load of word salad.

@eugene said in Women, and Why Men are the Problem:

You are a retarded slave

Your comments have made my day, always keep your serotonin low, it feels good to laugh like that. Nice username by the way Cristiano.

Regarding the subject, it's not a matter of being a man or woman, it's a matter of how much love, joy and excitement you feel and express on a daily basis through a functionnal body and mind. The rest is only illusions that distract us from being who we really are, including those useless gender conflict that stems from a lack of self love and self acknowledgment.

@questforhealth I did benefit a lot from psychedelics, in fact, without psychedelics I would not have taken my health seriously and couldn't even imagine that it was possible to live a life free of physical and mental illnesses.

I'm living in Europe btw.

Agmatine sulfate is hard to get in UK and Europe, but you can order it easily from the US from Nootropic Depots or Bulk Supplements, 250g for around 35-45€ shipping included.

Memantine, Amantadine, Dextrometorphan are also good in my opinion as I had the chance to try them too. I have a preference for Agmatine and Memantine.

I don't know if Dextrometorphan is otc in UK, if it's the case, it is worth trying to see if NMDA antagonism truly improves symptoms or not before spending 40$.

Gou Teng is also very underrated and is used quite a lot in Japan for ADHD and neurological related issues. It's a mix of NMDA antagonism, serotonin partial agonism and antagonism as well as partial agonism at D2 receptors. From all the herbal supplements I tried for neuroinflammation (and my wife knows how much I tried lol), Gou Teng, Ginkgo Biloba and Panax Ginseng were my favorite.

@questforhealth I'd rather call it a synchronicity

Hey Man, I had the same symptoms as yours, I couldn't digest anything, everything felt stuck.

I was reacting badly to almost every molecule inhibiting serotonin transporters.

I had the same exact problem with B1, it improved my symptoms short term before giving me severe anxiety. I tried every co-factor and almost every supplement on the market, as well as psychedelics, but nothing helped until I discovered Agmatine sulfate and Magnesium L-Threonate (I insist on this form as other magnesiums did nothing).

Those two are NMDA antagonists, and I suspect that I had very sensitive NMDA receptors as I was literally getting tense and severly anxious from taking glutamine, L-Theanine or NAC.

After starting Agmatine and Magnesium L-Threonate, I was able to take 200mg of Sulbutiamine without any side effect. My lifetime chronic anxiety disappeared, and I was finally able to digest without having everything hurting my gut and making me lethargic.

You may also be interested in looking at the god gene hypothesis and how this gene impact the amount of monoamines in the brain, leading to more "mystical" experience but maybe also more serotonin.

Selenium also helped me a lot, especially at maintaning a good body temperature, I always had cold extremities that disappeared after starting 400mcg of selenium l selenomethionine, I reduced to 200mcg after a few weeks, and now I don't take it anymore as I can absorb enough from food.

Edit : Brazil nuts did nothing for me, supplemeting Selenium did. I think that the selenium in brazil nuts is not a reliable source as it is poorly absorbed by the body, even more with digestive issues.

I think that serotonin and chronic tinnitus are highly correlated, a lot of people develop tinnitus after starting SSRIs.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040800/

@questforhealth You may have completely emptied your selenium reserves by following Charlie's funny advice lol

@Kvothe said in Whats the deal with "Vitamin" A?:

It's bad. Gets you banned from raypeatforum.

nice one

Add some fat like butter or coconut oil.

Selenium is very underrated, especially for the conversion of T4 to T3 and recycling of glutathion which improves overall oxidative stress, but even more now against heavy metals.

A disulfide thiamine derivative like the one in Energin. An NMDA antagonist such as memantine, agmatine or magnesium l-threonate. A source of phospholipids as well as coffee, ginkgo biloba and panax ginseng.

@questforhealth They will sometimes use poor quality oranges to compensate for the price of the machine unfortunately.

I was going to say shredded carrots with freshly pressed orange juice but it seems trickier.

I remember reading a study that showed better absorption and storage of Vitamin A when taking lecithin, this information might help you.

Cyproheptadine is not only a serotonin antagonist, but also an endotoxin antagonist (LPS/TLR4), which will reduce inflammatory reactions in the digestive system, thereby reducing serotonin production in the gut at the same time.

Ergot derivatives such as metergoline, bromocriptine, lisuride, lsd and others are fine to keep serotonin in check but are not suitable for daily use. I find that once every other day at least is the best to avoid side effects.

Coffee is a good source of xanthines and palmitoylethanolamide, two components that have shown good results at reducing the damage caused by endotoxins.

Pinocembrin, a flavonoid in Damiana showed inhibition of the TLR4 receptor, it's worth a try.

If you don't tolerate coffee, guarana powder or yerba mate are good substitutes, and they're easy to find in Brazil.