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Peatbot.com: Based on the context provided, reducing cardiac fibrosis can be associated with the regulation of collagen gene expression and the influence of thyroid hormones. Here are some insights from the studies mentioned:
- Thyroid Hormone Treatment:
- The study by Yao and Eghbali (Cardiovasc Res 1992) suggests that thyroid hormone treatment can lead to decreased collagen mRNA and regression of cardiac fibrosis. In the tight skin mouse model, thyroid hormone treatment resulted in diminished collagen content and the disappearance of cardiac fibrosis. This indicates that thyroid hormone may play a significant role in preventing and regressing cardiac fibrosis through endocrine pathways.
- Negative Regulation by Thyroid Hormone Receptor:
- The study by Chen et al. (Mol Cell Endocrinol 2000) provides evidence that thyroid hormone receptors negatively regulate the pro-alphal(I) collagen gene expression. This suggests that maintaining adequate levels of thyroid hormones could potentially reduce collagen synthesis and thus cardiac fibrosis.
- Avoidance of Hypothyroidism:
- Hypothyroidism has been associated with increased myocardial fibrosis due to the lack of thyroid hormone, which leads to increased collagen synthesis. Ensuring proper thyroid function might help in reducing the risk of developing cardiac fibrosis.
These studies highlight the potential of thyroid hormones in managing cardiac fibrosis. However, it is important to consult with healthcare professionals for personalized medical advice and treatment options.
