Posts made by DavidPS

@Mauritio This is a https://dictionary.cambridge.org/dictionary/english/connect-the-dotsing area. Perhaps this will help.

Hyperhomocysteinemia and Disease—Is 10 μmol/L a Suitable New Threshold Limit? (2024)

@LucH - Thanks for your reply. I am here to learn as well as help. It seems that you are always connecting dots that I failed to consider.

@Mauritio - Homocysteine (Hcy) is an amino acid and it is strongly correlated with dementia (both Parkinson’s disease (PD) and Alzheimer’s disease (AD) ) and vascular disease including stroke. The metabolism of Hcy is linked to that of several vitamins—especially folate, B6, and B12. Concentrations of homocysteine can be inexpensively and safely lowered by treatment with a combination of these B vitamins.

(see source)

Homocysteine and Parkinson's disease (2023)

Association analyses of nutritional markers with Parkinson’s disease and Alzheimer’s disease (2024)

Homocysteine and Alzheimer's disease (2003)

Homocysteine as a predictor of cognitive decline in Alzheimer’s disease (2010)

Homocysteine, vitamins, and vascular disease prevention (2007)

@LucH said in "Jimmy Carter has spent over a year in hospice care. How has he defied the odds?" (and he turned 100):

Note: Always better when you can move and have objectives.
Would be interesting to optimize a technique to improve physical equilibrium.
If you're 60ies or older, make the following test:
Near a door or a table, shut your eyes;
Open your arms at the horizontal;
lift one knee and see if you can keep this position 20'' without falling.

The following video was posted today. I describes some easy exercise to improve balance.

https://www.youtube.com/watch?v=jbMvh4Zs_Uc

Brain shrinkage/atrophy is often thought of as a natural consequence of aging. The medical/pharmaceutical system likes to assign disease names to different patterns of brain shrinkage and then focus on drugs to treat the symptoms that manifest after the brain shrinkage become pathologic.

There are diet and lifestyle choices that accelerate aging and others that slow brain shrinkage. I am wondering if slowing brain shrinkage will delay the onset of dementia. The idea is to reduce the rate of brain shrinkage so that dementia is postponed. It seems like the medical/pharmaceutical is ignoring the idea decelerating the rate of brain shrinkage. It would not be in their shareholders interest.

One strategy for slowing loss of brain structure is to reduce your homocysteine by getting adequate levels of B vitamin in your diet.

Critical levels of brain atrophy associated with homocysteine and cognitive decline (2014)

Abstract

Few B-vitamin trials to lower homocysteine (Hcy) have reported evidence of beneficial effects on cognition in older adults with cognitive impairment or Alzheimer's disease. This article reviews the role of Hcy in cognitive decline. It also considers some reasons why meta-analyses have failed to find effects of B-vitamin treatment. Findings from the successful VITACOG trial are examined from a new perspective of critical levels of Hcy and brain atrophy that may impact on the efficacy of B-vitamin treatment. It appears that there is a critical level of brain shrinkage, possibly mediated by elevated Hcy, which when reached, results in cognitive decline, especially in episodic memory performance. Supplements, food sources, and effects of folic acid fortification are discussed in relation to B12 deficiency.