Posts made by Mauritio

Interesting.
I think people aren't aware of how difficult it can be to correctly dose T3 ,let alone T4.

@OliverCloasov
It seems that charlie accuses people exactly of the things that he is doing.
psychologically speaking it that is the repressed shadow trying to find a way to make itself free/heard.

L. Reuteri increases Vitamin D. Maybe by increasing cholesterol conversion into vitamin D since it also lowers cholesterol.

"L. reuteri NCIMB 30242 increased serum 25-hydroxyvitamin D by 14.9 nmol/L, or 25.5%, over the intervention period, which was a significant mean change relative to placebo of 17.1 nmol/L, or 22.4%, respectively (P = .003)."
https://pubmed.ncbi.nlm.nih.gov/23609838/

@cs3000 said in 2 studies showing cancer reversal / shrinking:

@cs3000 said in 2 studies showing cancer reversal / shrinking:

@Mauritio yep and i imagine daily would be even better, interesting that short duration was effective it does work broadly yeah
here it had less profound effect in a connective tissue cancer but still good
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499556/#s2title they did 10 minutes instead of 20 minutes .
I just saw something amazing actually when they tested it on breast cancer in vivo it almost didnt grow at all :

Here we go, big one
https://www.spandidos-publications.com/10.3892/or.2017.5591
great studies by these people exploring all the angles

Surprisingly going for more days of co2 weekly didnt give better effect, 2 days is enough,
but going for longer than 10 minutes does give more improvement (20 minutes worked better) in breast & bone cancer, effect peaks around there as 1 hr did not give better effect

• Additionally, in a preliminary study, no further decrease in tumor volume was observed with the 1-h treatment compared to the 20-min treatment
• For the CO2 therapy, there was no difference in effectiveness of frequencies of twice and five times per week; in addition, a twice-weekly treatment regimen was sufficient to inhibit in vivo tumor growth, even in MFH/UPS, which is a high-grade sarcoma cell line.

And they found the cancer regressed below baseline with 20 minutes applications, in all of the mice

And they even said two of the breast cancer tumors disappeared @haidut

Bone tumors also got smaller below baseline
.... this is happening fast over a few days / weeks ... amazing

it did not work as well on a rarer aggressive sarcoma tumor. but slowed growth with this (which the table doesnt show)

• in addition, a twice-weekly treatment regimen was sufficient to inhibit in vivo tumor growth, even in MFH/UPS, which is a high-grade sarcoma cell line.

• In the current study, the most significant antitumor effect was observed in the MDA-MB-231 breast cancer model. At the end of treatment, all treated tumors in the MDA-MB-231 model were smaller than pre-treated tumors, and notably, two of the six tumors in the 20-min group had disappeared

Additionally, using a treatment frequency of twice per week, tumor volumes were smaller with a treatment interval of 3 and 4 days than with a treatment interval of 2 and 5 days.
We also found that transcutaneous CO2 application was ineffective when applied at a distant site relative to the tumor location. Therefore, the CO2 therapy should be applied to the body surface close to the tumor location.
We previously developed an alternative system for CO2 application that can access deep-seated tumors using intra-arterial infusion of saturated CO2 solution (20). These findings suggest that continuous treatment, twice per week with an interval of 3 + 4 days, applied to the local site of the tumor, provides the best antitumor effect for transcutaneous CO2 application.

So 20 minutes, enhanced by a co2 capturing gel locally to the tumor site, 2 times per week, every wednesday and sunday (3 & then 4 days), gives max effectiveness

sounds like simple glycerol/glycerin + water could work for the gel,
or sodium alginate
(majority water as long as its thick enough to not run down skin)
https://patents.google.com/patent/JPWO2004002393A1/en?oq=WO2004%2F002393

• A viscous liquid prepared using 2 parts by weight of sodium alginate as a thickener and 98 parts by weight of purified water as water is impregnated into a 4 cm diameter polyester nonwoven fabric, and this is immersed in a 1% calcium chloride aqueous solution to support the nonwoven fabric. A hydrogel film of calcium alginate as a body was prepared, and this was adopted as a carbon dioxide absorption aid 4

• An appropriate amount of the carbon dioxide absorption assisting material 4 is applied to a 5 mm diameter scratch on the left back of a 37-year-old woman, a left hand is put in the sealed envelope 2, and carbon dioxide is supplied to the sealed envelope 2 by the carbon dioxide supply device 3 to 10 seconds at a rate of 200 milliliters / second, and then 5 minutes at a rate of 20 milliliters / second. When the auxiliary material was washed away, the pain felt before touching the water completely disappeared, and the wound healing promoting effect was confirmed.

• A 48-year-old man's 5cm square carbon dioxide absorption aid 4 is affixed to the left back of the 48-year-old man, and without putting anything on the right back, each hand is put in the two sealed enclosures 2a and 2b, and each enclosed enclosure Carbon dioxide was first supplied to the material 2 from the carbon dioxide supply device 3 at a rate of 200 milliliters / second for 10 seconds and then at a rate of 20 milliliters / second for 7 minutes.
  The man's hands quickly became warm, but the left back felt warmer than the right back.

Gel + ~ 7 Liters of co2 gas sealed in a 20cm long plastic bag was enough for pain reduction and wound healing effect in this woman

Wow ,what a study!

So it does work for some but not all tumors. But it seems to at least help in all tumors for almost no cost and risk involved. Sounds great.

If the CO2 application is applied too distant from the tumor it doesn't work, though. So if you have a big bag for the CO2 bath, that only goes up until your navel and your tumor is in your thyroid, it won't work.
So for prevention purposes the bag should cover as much body surface area as possible, because you never know where a tumor is developing. Although I'm sure there's something like a beneficial bystander effect. Even if you only bath your foot in CO2 , the whole body will benefit.

Peat said just having a wet body surface enhances absorption so after showering would be good time .

@cs3000 said in 2 studies showing cancer reversal / shrinking:

i saw a pic someone posted in a co2 thread with a crazy tall straight clear bag strapped around his head going right up to the ceiling, and was taken from low angle as extra perspective, creased me up , imagine experience of a delivery guy walking in on this lol, "welcome, have you heard about ray peat" before he leaves.
& probably not the safest, but i respected the effort,
will have alook at that

Lol ... The word peatard exists for a reason

@cs3000 said in 2 studies showing cancer reversal / shrinking:

I just saw something amazing actually
when they tested it on breast cancer in vivo it almost didnt grow at all

Nice so it works for breast cancer as well.

This might explain the effect on autism. Autistic people have low GABA.

"We found that camel and goat milks have significantly more bioavailable GABA than cow and human milks and are able to activate GABAρ receptors."

• https://pubmed.ncbi.nlm.nih.gov/24128504/

Also:
https://pubmed.ncbi.nlm.nih.gov/33802798/

Watch out for a possible vitamin B2 deficiency.

You should also check out the effects methionine restriction on cancer , especially as a combination with methioniase. There's some impressive case studies in humans as well.

@cs3000 said in 2 studies showing cancer reversal / shrinking:

@cs3000 carbon dioxide therapy co2 came close ,
20 minutes in a bag filled with co2 that covers half the body, amazingly just twice a week, enhanced by a gel applied locally
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0100530

Wow that one is impressive !! RP right again.
So doing a CO2 bath a la Ray peat should be a very good cancer prevention even just once or twice a week!

In this study they used a skin cancer , im wondering if other cancers would react the same way. In the abstract they say that it decreased lung metastasis in a previous study, I'd still like to see more studies with dofferenr tumors.

That treatment setup with mice is kind of hilarious

Camel milk works as a treatment for diabetes
https://pubmed.ncbi.nlm.nih.gov/33747450/

In this study camel milk has anti-cancer effects and bovine milk doesn't.
https://pubmed.ncbi.nlm.nih.gov/22654482/

Camel milk removes the toxic effect of lead on sperm, liver and kidneys.
https://pubmed.ncbi.nlm.nih.gov/38455217/
https://pubmed.ncbi.nlm.nih.gov/36697983/

Tryptophan can go down the kynurenine, pathway, the serotonin pathway or the indole pathway.
L . Reuteri increases Tryptophan metabolism into the indole pathway, which lowers its availability for the serotonin pathway.
Not only that, the metabolites of this specific pathway have anti-inflammatory effects. They treat experimental colitis.
One even acts on the pro-metabolic PXR , similarly to pregnenolone or progesterone.

"As expected, the expression of Pxr (also known as Nr1i2), a receptor for IPA [41], and PXR target genes Ugt1a1 and Cyp3a11 increased markedly in the colon of DSS-treated mice in response to L. reuteri (Fig. 1E)."

• https://pubmed.ncbi.nlm.nih.gov/33777052/

L. Reuteri protects from ionizing radiation

• https://pubmed.ncbi.nlm.nih.gov/38465872/

L. Reuteri (KCTC 3594 and KCTC 3678) should help with acne via killing acne causing bacteria.

• https://link.springer.com/article/10.1007/s12275-012-1286-3

In this study another L. Reuteri strain 36301, caused a Testosterone increase of about 250%, in males that is. In females it caused shinier hair and skin and no testosterone increase.
It also reduced weight gain during aging and the inflammatory cytokines TNFa .

In the OP of this thread the testosterone increase was dependant on IL-10 , while in this study they did not find a difference in that marker, so there has to be another mechanism of action.

• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837529/

Interesting read.
I couldnt find anything on it lowering serotonin, but it does seem to have broad anti-inflammatory effect.

I cant tolerate any type of milk Ive tried so far, so Ill try camel milk.

" The antioxidant effects of α-lactalbumin, β-caseins and vitamin C of CM work by reducing or inhibiting the production of reactive oxygen species (ROS), hydroxyl radicals, nitric oxide (NO), superoxide anions and peroxyl radicals, likely alleviating oxidative stress."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039309/

@Amazoniac I noticed some transient vitamin B2 and biotin deficiency symptoms.
Although I suspect that's more due to killing the bacteria that produce those vitamins via reuterin.

@Ismail yes I increased to 3/4 of a tablet and will increase further soon.

L. Reuteri 6475 potently increases the serotonin Transporter SERT, which picks up serotonin and thereby reduces its availability.
They also showed that it reduced colitis in a rat model and lowered inflammatory cytokines like IFNy or TNF.

https://pubmed.ncbi.nlm.nih.gov/34550056/

DSM 17938, the other strain in Bio Gaia's Gastrus, also decreases serotonin. In this case directly.
Interestingly the effect took a while to show,but after that inertia, the longer they took it the more it lowered serotonin.

https://pubmed.ncbi.nlm.nih.gov/30574801/

@Amazoniac are you aware of any vitamins that L. reuteri consumes?
I only recall reading about it producing B12, but other than that I haven't come across anything like that.

In this study they showed that feeding flies L. Reuteris (ATCC strain SD-5865) it increased their life span by about 14%.

The mechanism was (amongst others)a decrease in IGF1, similarly to protein restriction.

Young flies were especially susceptible to the effects, their food intake was increased by 53% and their activity level was increased by 95%. l. Reuteri is/was part of the human milk microbiome so maybe it is supposed to be there in young animals

The flies also weighed less and consumed more food.

L. Reuteri decreases the abundance of bacteria in the gut, mostly by production reuterin. Giving flies reuterin alone increased their life span by up to 11% , indicating that it is largely responsible for the the life span. Increase of L. reuteri.

• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10389828/