Posts made by Santosh

@zawisza said in Why does only starch raise my temp well? (and sugar not):

@Santosh extremely not peaty

And ?

@neverever said in Why does only starch raise my temp well? (and sugar not):

@Santosh do you think its possible to fix microbiome while taking ppi? Or first have to fix gut lining or whatever and just deal with it. I have mastic gum and carrot salad, raw honey and lots of coconut oil but i still get white tongue in the morning

The only way to fix your gut is a raw carnivore diet

@Buckian said in Creatine and Ray Peat:

@Santosh easy there brother - you’re ganna hurt yourself.

You may notice that the original question in the post was about Dr Peat’s thoughts on creatine (not what current studies/conventional wisdom are for dosing creatine). My response was saying that I recall Dr Peat saying that a dose of 5g per day is too high but cannot recall the exact reasoning. Now the concern of ‘overdosing’ would be in light of this paraphrased Dr Peat statement - not because I think it’s a concern.

So if anything - I would say that I’ve taken this thread more seriously than you by actually answering the question at hand and not making assumptions about the users and their comments.

So as you say be rigorous.

I was refering to your "lol" which was useless.
Don't do useless things, it's annoying.

And stop writing lengthy paragraphs, it's highly feminine. I can almost picture you beginning every sentence by "excuse me but" when talking in real life.

@pannacottas said in Experiments with transdermal hormones:

@Crypt-Keeper said in Experiments with transdermal hormones:

@pannacottas said in Experiments with transdermal hormones:

@Crypt-Keeper I've ordered dht base from QSC and had it tested at Janoshik, came back with 98%+ purity. Imo they are legit and they have better prices that PPL anyways.

Thank you. Have you tried DHT in DMSO? Do you feel anything? I also have some DHT from PPL (same shipment) which has slightly different characteristics to the T base so I might try it in DMSO to see if at least that is legit.

I have tried alphagels DHT in DMSO which gave me the most insane contact urticaria ive ever experienced. Like an allergic reaction that lasted for about an hour or two, made my skin lizard-like and stang like crazy. I dont know what quality DMSO he used but that reaction is enough for me to never try DMSO again.
So i couldnt really tell any effects from the DHT because of that reaction.
However QSC powder dissolved in 95 ethanol (managed about 35mg/ml, im getting anhydrous 100% ethanol soon which will give a better concentration) produced noticeable effects, like strong reduction in estrogenic libido, mental clarity, and a sense of calmness.
Also dry scooping 100-200mg powder and swishing/holding with some raki is probably very effective too because brought my strength back up to my previous peak after almost a month of no training, and definitely produces the same calmness effect.

And you don't experience that peak strength with transdermal DHT ?

@yerrag said in Creatine and Ray Peat:

@Santosh

I'm with you.

Peat has made references to A Greek doctor and his clinical experiences on treating patients with urea and with creatine.

Urea used on wounds has antibacterial effects in that it cleans up decaying flesh in the wounds, thus depriving bacteria of food and in this way stops infections dead on its tracks. I use urea on my wounds and on my pet cats' wounds. Very very effective.

It has a similar kind of effect when ingested, as it goes to the liver and heals the liver. I've taken 30g/day for two weeks each time, and have seen my ALT and AST enzymes go down.

However, urea is deactivated past he liver and does little internally. And this is where creatine is used.

I would put 30g urea and 14g creatine in a liter of water and drink it throughout the day. At worst, the creatine would do nothing. As that has been my experience once.

But I plan on taking this shortly for two weeks, as I want to see the effect on my ataxia (or Parkinson's). My theory is that creatine would work like urea on the protein sediments or sludge on the blood vessels and clear them up. I can see this in the ESR going down if it works as I think it should.

With ESR going down, blood flow would also improve and the delivery of nutrients and oxygen to the brain would improve, and as a result my symptoms of ataxia would go away.

Don't use creatine if you are still drinking coffee, it will make you pee like a horse and wake you up multiple times at night.

@Crypt-Keeper said in Experiments with transdermal hormones:

@Santosh said in Experiments with transdermal hormones:

Slightly different characteristics ?
Based on what ? What you've read on forums ?

These are two completely different hormones with completely different feelings, not "slightly".

I really wonder if you are for real sometimes

"Slightly different characteristics" in that the DHT that PPL sent me is a lot more fine; it's almost like powdered sugar. The T base they sent me is definitely a larger particle size, not quite the size of granulated sugar but definitely not as fine as the DHT. If I touch the DHT powder it's fine enough to get into my fingerprint grooves, and needs to be rinsed off; whereas the T base is not and can simply be brushed off. So they definitely sent me two different substances. I can tell my looking at them and feeling them that they are not the same.

And there are plenty of people out there that have claimed to get bunk from PPL. And why wouldn't PPL send out a certain percentage of their shipments as bunk? Customers have no recourse. It's not like they can call the police about it. And anybody who complains about it on a forum is accused of posting a "fake review". PPL simply says that everybody is lying, which is very convenient.

I order from PPL every 3 months since 2019 and send a sample everytime to Jano.
Everything comes back at 98% purity.

@Buckian said in Creatine and Ray Peat:

@Santosh lol. Touché.

Stop loling unless you also use pronouns to define yourself.
Keep a serious tone, work hard, have values, stop taking everything lightly, be rigorous.

@Crypt-Keeper said in Experiments with transdermal hormones:

@pannacottas said in Experiments with transdermal hormones:

@Crypt-Keeper I've ordered dht base from QSC and had it tested at Janoshik, came back with 98%+ purity. Imo they are legit and they have better prices that PPL anyways.

Thank you. Have you tried DHT in DMSO? Do you feel anything? I also have some DHT from PPL (same shipment) which has slightly different characteristics to the T base so I might try it in DMSO to see if at least that is legit.

Slightly different characteristics ?
Based on what ? What you've read on forums ?

These are two completely different hormones with completely different feelings, not "slightly".

I really wonder if you are for real sometimes

@Crypt-Keeper said in Experiments with transdermal hormones:

@Santosh said in Experiments with transdermal hormones:

Your powder is bunk, indeed.

I guess I will send it off to Janoshik since it's probably important to know what I'm taking into my body with DMSO.

I found it strange that PPL had a message on their website saying not to test with Janoshik and anyone who posted results from them on a forum would be banned from buying again.

Guess I'll look elsewhere for raws.

Nothing strange about this, they just don't want you to claim a refund based on a testing piece of paper that could have been after you sending anything to Jano.
How can you prove to PPL you actually sent testosterone for testing and not sugar ?

@neverever said in Why does only starch raise my temp well? (and sugar not):

Ray peat wasnt vehemently against starch and so are many people here that are consuming it even daily but still many people are saying Sugar to be superior to starch so I wonder if this indicates something wrong in my metabolism?
I need starch to get going really else ill stay at 36.3 from waking but i eat starch i get to feel warm in my whole body and temp goes to 36.7 underarm and i feel better. I eat sugar in for breakfast like Pear juice, gelatin, fruit, honey, greek yogurth and i dont find it to raise my temp really at all. At night i eat sugar to keep my hands warm and works but also not fantastically but i cant eat starch so late due to gastritis and ppi cause me digestion problems.

Because you have dysbiosis and only starch moves you bowel enough for bacteria not to stagnate and release endotoxins.

@cs3000 said in Antibiotics causing fungal infections - mechanism is through reducing IL-17a and GM-CSF immune cells:

https://www.sciencedirect.com/science/article/pii/S1931312822002190

IL-17A and GM-CSF {in cd4 T cells or Innate lymphoid cells} protect against antibiotic-induced susceptibility to invasive candidiasis
. antibiotics disrupt cytokine production from GI-tract-resident CD4 T cells and innate lymphoid cells (ILCs), particularly IL-17A, IL-22, and granulocyte-macrophage colony-stimulating factor (GM-CSF)
. IL-17A is a critical antifungal molecule at the mucosal barrier, as inborn errors of IL-17 immunity cause mucosal candidiasis

We found that antibiotic pre-exposed Il22−/− animals had greater mortality post-fungal infection compared with Il22−/− animals that did not receive antibiotics (Figure 3C), indicating that IL-22 is not required to mediate the susceptibility phenotype in this model.
By contrast, mice lacking either IL-17A or GM-CSF exhibited similar susceptibility to fungal infection regardless of antibiotic pre-exposure

In addition to IL-17A, we found that GM-CSF production was reduced by antibiotics and that the presence of GM-CSF was required for the development of antibiotic-induced susceptibility during invasive candidiasis. GM-CSF has been shown to have a protective benefit against invasive candidiasis in humans (Dignani et al., 2005; Gavino et al., 2014). We show here that GM-CSF can ameliorate mortality in the setting of antibiotic-associated invasive candidiasis in mice. GM-CSF treatment may be effective at boosting the antifungal activity of myeloid cells

IL-17A production by CD4 T cells is especially sensitive to antibiotic treatment, as we confirmed here. IL-17A is a key antifungal cytokine at mucosal sites since patients with IL-17 receptor signaling defects are susceptible to mucosal candidiasis and enhanced C. albicans GI colonization
Indeed, we found that IL-17A was required to control the C. albicans infection of GI tissues in the setting of antibiotic pre-exposure

{they dont lower il-17a t cells directly - they lower the bacteria that helps induce IL-17 t cells "Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria"}

Another driver of gut Th17 cells is microbial-derived ATP. Both SFB and bacterial ATP are reduced by antibiotics, which has been linked to reduced IL-17A production.
vancomycin specifically enhanced the susceptibility to C. albicans following long-term oral treatment and only indirectly via dysbiosis

How do you upregulate those after a course of antibiotics ?

@Buckian said in Creatine and Ray Peat:

@Santosh this is an option. However, if the concern is overdosing further research and prudence may help.

Overdosing creatine ?

Just take 5g and go on about your day, I swear you guys are creating problems that don't even exist in the first place.

@Crypt-Keeper said in Experiments with transdermal hormones:

I finally got around to trying T in DMSO. Maybe 100 mg T per 1 ml DMSO was too concentrated because there were some crystals left over after application. No white residue or powder, but definitely some kind of tiny glitter on my skin that was only visible in bright light.

I tried 25mg, 100mg and 200mg applications and felt absolutely nothing different. Absolutely nothing. Like as if I smeared water on my skin (other than the DMSO burn).

This is about what I expected though. Some would be tempted to say that my powder is bunk, and maybe it is. But it confirms my suspicion that those who "feel" something from these hormones are either working with placebo, or have low testosterone to begin with. Mood, energy, strength -- nothing. Probably once you're in the high-normal range for T, blasting into the stratosphere doesn't do much more for you.

I think I will run this bottle out with 5-15mg applications once or twice a day just to help keep T in the upper range.

DMSO is awful to work with. Completely impractical for a regular basis. I'll try the (95%) ethanol formulas next.

It would be good if there was a way to pre-treat the skin with some kind of 5-ar inhibitor like topical finasteride to prevent DHT conversion. But then DMSO would bring that in and make it systemic, which you wouldn't want.

Overall I would say that I'm completely unimpressed. But microdosing T with a non-DMSO formula over the long haul might be helpful for gym purposes at least.

Your powder is bunk, indeed.
There is nothing placebo about the testosterone base surge you feel in DMSO, especially when you use 100mg or more at a time.

Those who have tried it know.
Those who wish they tried it scream placebo.

@brightside said in Experiments with transdermal hormones:

@Santosh said in Experiments with transdermal hormones:

What specific points make you think I do ?

Elaborate, don't just throw sarcastic questions especially while hypocritically prefacing they are genuine.

Why would I elaborate when you won't read it anyways? That's the point.

I'm not hypocritical, though. If you answer genuinely, I will too. Not everyone's like you

Prefacing a question with the word "genuinely" while making this question rethorical and sarcastic is, indeed, hypocritical.

@noodlecat59 said in Homemade progest-e Vs r real progest-e...:

@Santosh so is suchlabs progesterone bad or what? did you confirm it? idk why you are being so evasive sir. ive got a bag of it here from before they shut down and it would be helpful if i knew how to value it. if you say its bad im more likely to toss it rather than waste time with it

I already said above they scammed me.
And you add that they shut down.
What other proof do you need that whatever product they sent you will be salt or sugar, who cares what product it is.

So I should be the one spending thousands dollars on testing and you can benefit from it for free ?

@noodlecat59 said in Homemade progest-e Vs r real progest-e...:

@Santosh I'm not sure what your deleted post said but I asked you what specifically you ordered from them that isn't what they claim it to be.

It didn't say anything more than the post that follows, I had just mistakenly deleted some of your words so I figured I would quote your whole question back again.

@BeamsOfEnergy said in Homemade progest-e Vs r real progest-e...:

@Santosh I was looking for progesterone derived from wild yam like progest-e, PPL say theirs is synthetic. Not sure if that makes a difference.

Synthetic means it's recreated, including when it's from wild yam.
Testosterone, estrogen and progesterone can all be made from wild yam, the yam is just the base product that you have to transform.

@haidut said in A combination of vitamin B1/B3/B7 and aspirin, has curative effects on human mantle-cell lymphoma:

Yay, my first post here!
Wanted it to be about the recent study I did. While the results will have to be replicated with a follow-up experiment, with more animals, and additional groups for comparison, this results has never been seen before with this tumor type, which is 100% lethal and has no known case of spontaneous regression (i.e. disappearing on its own, without treatment). Basically, 2 out of 3 animals were fully cured in this experiment/study.
https://twitter.com/haidut/status/1751716166387597730

Human-equivalent doses for the substances were ~15mg/kg vitamin B1 (thiamine Hcl), 30mg/kg vitamin B3 (niacinamide), 1.5mg/kg vitamin B7 (biotin), and 15mg/kg aspirin. Administration was once daily, orally.

Good for those who can handle a B vitamin complex !

I can't, whether metylated or not, it makes me anxious, nervous and depressed.

@noodlecat59 said in Homemade progest-e Vs r real progest-e...:

@Santosh What was it supposed to be that they sent you and how did you determine that it isn't what it is supposed to be?

I always send every single powder I receive for third party lab testing.
I order around 5000$ worth of various steroids a year and spend close to 1000$ in testing every year.