Dandruff or scalp irritation? Try BLOO.
@Mulloch94 said in Homemade progest-e Vs r real progest-e...:
@BeamsOfEnergy said in Homemade progest-e Vs r real progest-e...:
@Mulloch94 yeah I'm leaning towards the p4 being the issue as I calculated the mix based on 3mg per drop. Anyone know any good progesterone powder?
I think PPL sells raw progesterone powder. I don't know the quality of it though.
98%
@BeamsOfEnergy said in Homemade progest-e Vs r real progest-e...:
@Mulloch94 yeah I'm leaning towards the p4 being the issue as I calculated the mix based on 3mg per drop. Anyone know any good progesterone powder?
PPL
@Crypt-Keeper said in Experiments with transdermal hormones:
@Santosh What is the mechanism of tren fixing anhedonia? I might have to give this a try, although I think mine might be more related to low E2.
Strong androgen receptor agonism that finally wakes up the dormant receptors that haven't been used at all your whole life.
Look at how you and your generation looks like : soft cheeks, soft skin, frail looking without much muscle, thin neck, no energy.
Look at how men who were born in the 50s look like : thick leathery oily skin with strong beards, thick necks, broad shoulders, natural muscle mass without working out, very strong will and never back down when a fight comes up.
That means your receptors haven't worked much since the day you were born because of EDCs, the medications your mother took when she was pregnant, the soft way of life with computers you live.
@Mulloch94 said in Experiments with transdermal hormones:
@Santosh What's the significance of knowing them personally? Last time I checked there isn't some grand conspiracy against trenbolone. It's a substance that serves a particular purpose, and like anything, can have adverse reactions. Also 3 two week cycles isn't that much. I'm sure most people can get away with that before it becomes a huge issue. The typical tren cycle is like 10-12 weeks.
Also you're acting like the only knock on tren thus far is personal anecdotes on forums. We know from research it can elevate prolactin and downregulate serotonin autoreceptors (which isn't good). This supports some of the notable cardio effects users talk about on those forums, like tachycardia and, in extreme cases, heart failure.
Completely reversing anhedonia only took 3x2 weeks.
You agree that this length of time is not enough to give any harmful effect.
Why do you keep preaching the harmfulness of these drugs then ?
@BeamsOfEnergy said in Homemade progest-e Vs r real progest-e...:
@Mulloch94 I do trust progest-e but I was trying to make my own and I thought it was as simple as mixing the powder and vitamin e together. Was just trying to figure out why it didn't work.
Yes, it's that simple, providing you know what you are mixing.
@BeamsOfEnergy said in Homemade progest-e Vs r real progest-e...:
@Santosh as in it didn't work?
As in they send you something that is not what it's claimed to be
@Mulloch94 said in Experiments with transdermal hormones:
@Santosh Do you not think all the accounts people have of themselves (or family members) going crazy and literally threatening to harm themselves or others when taking tren isn't proof enough of it's toxic effects?
You know these people personnally ?
Anybody can write anything on the internet, including me.
That's why you need to try these things for yourself.
@BeamsOfEnergy said in Homemade progest-e Vs r real progest-e...:
I bought 30ml vitamin e liquid and progesterone powder from suchlabs.
Using a magnetic stirrer I heated the vitamin e slightly and slowly added the progesterone to make a 3mg per drop solution (similar to progest-e). The powder dissolved perfectly and even after a few days showed perfect dissolution.
However I tried taking a kernel sized amount each night before bed and noticed... Nothing! Out of curiosity I ordered kenogen progest-e and took the same amount at bedtime and reliably my morning temps shot up 0.4c each morning and pulse increased by approx 5bpm.
My question then is why didn't my homemade solution work? It looked like it dissolved perfectly. Is it the powder? The vitamin E? Anything I could be missing?
Thanks for any help.
@BeamsOfEnergy said in Homemade progest-e Vs r real progest-e...:
I bought 30ml vitamin e liquid and progesterone powder from suchlabs.
Using a magnetic stirrer I heated the vitamin e slightly and slowly added the progesterone to make a 3mg per drop solution (similar to progest-e). The powder dissolved perfectly and even after a few days showed perfect dissolution.
However I tried taking a kernel sized amount each night before bed and noticed... Nothing! Out of curiosity I ordered kenogen progest-e and took the same amount at bedtime and reliably my morning temps shot up 0.4c each morning and pulse increased by approx 5bpm.
My question then is why didn't my homemade solution work? It looked like it dissolved perfectly. Is it the powder? The vitamin E? Anything I could be missing?
Thanks for any help.
Suchlabs also scammed me
@Mulloch94 said in Experiments with transdermal hormones:
@metabolicmilk What would be the purpose for trying something like Tren in the first place? It's a pretty destructive substance that has essentially no health benefits to it. The only people who need to consider Tren are people trying to get as big as possible, and even most of them know you're playing with fire when you take that shit. I mean, it's your body. I don't care if people smoke crystal meth, I'm just genuinely curious how we go from "fixing the metabolism" to trenbolognia sandwiches.
Read my post above.
Stop thinking you may know anything about a hormone in particular just because you read forums.
@metabolicmilk said in Experiments with transdermal hormones:
@Santosh Have you ever experimented with tren base topically?
Yes ! With tren base and Mtren in DMSO.
Completely cured my anhedonia and conditional fear I had developed abusing MK-677 in the past.
They are truly a miracle.
I did 3 cycles of two weeks high dose of both.
@Kilgore said in PSA TO ALL PPL/DO (PurplePandaLabs/DragonOrdnance) SHOPPERS:
@brightside Wow. Thanks for this. Before I made the mistake of ordering. Sooooo where can I get DHT from?
From PPL.
They never let me down
@Ecstatic_Hamster said in PSA TO ALL PPL/DO (PurplePandaLabs/DragonOrdnance) SHOPPERS:
I've had impeccable experience with Purple Panda Labs.
Same, always received the within 5 weeks and tested at 99% purity.
@brightside said in Experiments with transdermal hormones:
@Santosh said in Experiments with transdermal hormones:
@brightside said in Experiments with transdermal hormones:
@Santosh said in Experiments with transdermal hormones:
Oh I see, this whole thing is about your ego.
You can't accept that I started making threads about my discoveries back in 2019, and you arrived LONG after.Imagine my ego being tied to the topic of transdermal hormones LOL
I care about accurate information, which you bring none.
Notice how in my RPF thread, anytime I bring up any argument you keep deflecting and changing the topic or going for an attack. You never actually say anything.
Case in point being your reply to me just now.
Why switch your opinion?
Where's the logic and reasoning?
Where's the proof for such a bold claim?
Where's literally anything of substance?Man, I don't really care. You can stroke your ego all you want, just don't do it in my thread. This thread is for accurate information and brainstorming.
"Your" thread doesn't exist if I don't bring up the topic of transdermal hormones in September 2019 both on the RPF and on MesoRx with my homemade formulas, both the DMSO one and the Ethanol/MCT one.
You piggy backed on my threads making small adjustments to the formula that bring nothing new to the absorption rate.
Switch my opinion to what ? I always had the same.
Would you like a cookie?
Actually, if anyone deserves to be called a pioneer, it’s this guy from 2002.
Genuine question, do you have a problem with reading comprehension?
What specific points make you think I do ?
Elaborate, don't just throw sarcastic questions especially while hypocritically prefacing they are genuine.
@questforhealth said in Impact of Clothing on Health:
Liver pain from supplements... Gonna stay vegetarian and add freshly picked seafood eventually possibly for cholesterol or whatever. I just hope the sea where I live isn't polluted... You can get zinc from peas and if the gut microbiome is healthy its not a huge problem with all that fibre no?
Not much from plants is bioavailable.
Better eat raw muscle meat, raw organs, raw eggs, raw milk, raw honey.
@questforhealth said in Impact of Clothing on Health:
'Functional vitamin B2 levels were assessed in 600 children with autism aged between two and 30 years old. Every child assessed was found to have functional vitamin B2 deficiency. The deficiency appears to have stemmed from deficiencies in Iodine, Selenium and/or Molybdenum as was found in a previous report by this lab. Functional vitamin B2 is a known essential co-factor in the maintenance of the activity of vitamin B12, and potentially this would also mean that each child was deficient in functional vitamin B12 – a known predisposing factor for autism.'
This is the thing I'm talking about. So those 3 nutrients are found in beans and fish mainly... No wonder I was craving fish and chips with mushy peas. if only it wasn't drowned in PUFA that would fix all my problems.... might jsut need to make it myself.,, and if Dr Peat said to avoid beans it might be pretty easy to get deficient. Especially if you are someone like me who can't digest meats...
Get your minerals and vitamins from actual food.
See how shitty you feel after taking zinc + B complex pills.
@Crypt-Keeper said in Revisiting Oral Testosterone:
Hello all!
There is a TL;DR summary at the bottom.
When it comes to "supplementing" testosterone, I know the TRT and bodybuilding bros insist that injections are the best and anything other than injections is stupid. But I tend to agree with the sentiment previously and extensively shared over at the "other" forum that injecting those ester formulas aren't very healthy and you can get raw, micronized powder pretty easily and DIY. The overall consensus from people like @Santosh and others settled on transdermal application.
I wanted to understand why every hormone on the planet can be taken orally except testosterone -- DHEA, pregnenolone, progesterone, estrogen, BC pill, etc. From what I read, although the bioavailability of T is high, it's rapidly metabolized in the first pass through the liver. Since I don't know what "metabolized" means in this sense, I learned some more and apparently a large portion of the T is converted to DHT in the intestinal tract and the liver, and then most of the rest into the other T metabolites, and so not much of the actual T hits the bloodstream. I guess there isn't a similar problem for the other hormones.
So I came across an older (2005) study [1] that tried to mix T powder with sesame oil (yeah, I know) and they got pretty decent results. They also added dutasteride (not sure how I feel about that) to suppress DHT conversion and got even better results. This was a heterogeneous mixture (so no dissolving of course) of micronized T suspended in sesame oil at a concentration of 100 mg/ml. (For reference, a ml is a little less than a quarter teaspoon, so this is a rather thick concentration.) This was "mixed thoroughly on a magnetic stir plate to create a homogenous T/sesame oil emulsion". I'm not sure if that's an important detail or just means that the powder was evenly distributed amongst the oil. The mixture was then "vigorously mixed (by shaking) with milk and administered to the subject".
The idea was to coat the T particles in oil so that they would be taken up by the lymphatic digestive system and bypass the liver, in a similar manner to how the fat-soluble vitamins A, D, E and K are taken up. It seems like the results showed some feasibility.
Here are the max results, which were achieved between 3-4 hours after administration. The subjects were chemically castrated down to almost zero T before hand, so the numbers indicate how much effect the oral T caused. In theory, for a normal person, these numbers would be added on top of one's baseline T.
T 200 mg (+ Dutasteride): 357 ng/dL (644 ng/dL)
T 400 mg (+ Dutasteride): 757 ng/dL (1459 ng/dL)
T 800 mg (+ Dutasteride): 1172 ng/dL (3541 ng/dL)It took about 10-12 hours for things to return to baseline, so I wonder if this could be worked to not interfere with natural overnight production?
They also tested with Testosterone Enanthate, which showed similar time to achieve max and similar return to baseline times, but in some cases higher maxes. (Not sure that I'm a fan of using an ester like this, but if clearance is quick maybe it's ok?)
TE 200 mg (+ Dutasteride): 424 ng/dL (586 ng/dL)
TE 400 mg (+ Dutasteride): 1502 ng/dL (2146 ng/dL)
TE 800 mg (+ Dutasteride): 4663 ng/dL (6641 ng/dL)Now 800 mg of T would cost about $1 per day at PPL prices, plus whatever for dutasteride. But I'm not convinced of the value of having such high T values? Wouldn't that be over and above what could be handled by the androgen receptors?
Regarding DHT, the only combination where it was kept below the upper reference range was 200 mg T + D, 400 mg T + D, and 200 mg TE + D. I know DHT is somewhat controversial; some in the looksmax community think it's a trash hormone, others say it's the most important for male characteristics; maybe the truth is somewhere in between.
E2 and SHBG were mid-range for all combinations. Probably the relatively short half-life kept the T from aromatizing. One subject did develop some small gyno however, which completely resolved within a couple days of the study. No liver or kidney toxicity was found.
"These data contradict the prevailing wisdom in the field, which states that the oral route for T delivery is impractical due to near-complete hepatic first-pass metabolism of orally administered T. Although it is true that the bioavailability of orally administered T is very low, probably around 1%, our work demonstrates that if sufficient T is administered orally in oil, potentially therapeutic levels of serum T can be achieved after oral dosing."
Building on this, I found a much more recent (2021) study [2] that took the same idea of powdered T in sesame oil but also added two solvents (benzyl alcohol and ethanol) and a surfactant (?) (propylene glycol monolaurate) and, in brief, was able to get about the same results as above with half of the dose (800 ng/dL with 200 mg T) but still struggled to keep DHT down (dutasteride was not used).
TL;DR Summary
- Micronized powdered T mixed in sesame oil, taken orally, does boost serum testosterone levels.
- The potential issues are: a) you need a decent dose (400 - 800mg) to get the bigger numbers; and b) you risk raising DHT too high.
- Both issues in #2 can be mitigated somewhat by supplementing with dutasteride.
- Some companies are goofing around with adding solvents to make the bioavailability even better.
- Not sure if this can practically be applied without interfering with natural production; e.g., to produce 2-3 "peaks" of high testosterone throughout the day (rather than just the natural single early morning one).
I am experimenting, but nothing to report so far.
Anybody have any thoughts? Anybody care about this stuff?
[1] Oral Testosterone in Oil Plus Dutasteride in Men: A Pharmacokinetic Study
[2] An oral lipidic native testosterone formulation that is absorbed independent of food
Either swallow the raw powder or apply it transdermally.
Do you really see yourself swallowing 8ml of pure oil every day ?
@questforhealth said in The relationship between Candida infections and heavy metal toxicity:
???
Is there a question ?
@Mauritio said in The relationship between Candida infections and heavy metal toxicity:
@Santosh said in The relationship between Candida infections and heavy metal toxicity:
@questforhealth said in The relationship between Candida infections and heavy metal toxicity:
Saving energy is important.
I emailed them this morning. If pectin helped so much I imagine emeramide can give me my life back. Big deal really. I also get more opportunities coming up to make money if I eat the right stuff and take the right supplements. Funny world.
I've always lacked energy and I know people with mercury poisoning say the same thing about lacking any mental energy so it's not laziness, how can someone be lazy, it's just a lack of energy... When it was at its worse I was walking into doors and forgetting how to open them and weird stuff.
I have probably had the worst case of mercury poisoning of this whole forum and powered through it with strength of mind.
You are in charge if your future, heavy metals are not.
Can you share a bit more about your story? I would really like to know how your symptoms looked and how you got rid of it and the whole process...
How I got rid of it : one gram OSR per day for a few months.
@Buckian said in Creatine and Ray Peat:
@raypneat I recall understanding him to say that it increases NO (please fact check) and that 5g per day is probably too high.
However, when answering he probably was thinking of it as person using it for the gym.
Cannot recall which podcast/ interview it was but I’ll post if I find it.
Just try it and see how you feel, no ?
