As I have been taking 4-8 mg of cyproheptadine for 2-3 weeks, I would like to share my thoughts and experiences:
During the first 3 days of taking cyproheptadine, I did not experience any significant symptoms, apart from noticeable sedation. Therefore, I decided to take the cypro at night instead of during the day. The first effects started appearing on the 4th or 5th day, when for the first time in years, I experienced what it was like to have deep sleep. As a result, my sleep duration increased from 6/7 hours per night to as much as 10 hours. This is likely related to an extension of the REM sleep phase and lower cortisol levels, due to the antagonism of 5-HT2A and 5-HT2C receptors. Additionally, my nasal breathing comfort improved, as I had been experiencing noticeable nasal issues due to excess histamine. However, I find it hard to wake up in the morning, with no passion for action, as I strongly desire to prolong my sleep (due to vivid dreams). After 7 days, every sleep phase had sexual content, and I frequently experienced nocturnal emissions, with morning erections. During the day, I felt more calm, controlled, and less aggressive, with a significant increase in libido (due to serotonin antagonism).
The problem I face is a lack of motivation, which is more likely related to my ADHD. Cyproheptadine antagonizes dopaminergic and cholinergic receptors, so during its use, I often resort to nicotine and caffeine.
I stopped taking it in the morning due to cognitive impairment; it became harder for me to formulate thoughts, and my vocabulary seemed more limited. This is related to acetylcholine, so I started experimenting with higher doses of nicotine from snuff.
I rate the experience 8/10. For those struggling with sleep, allergies, and aggression, I recommend it. However, due to the antagonism of dopamine and acetylcholine receptors, I suggest taking it cyclically during periods that don't require intense mental effort, such as holidays, to avoid unnecessary repercussions.
I would like to emphasize, however, that when there is no major issue with signaling, I believe the need for medication is unjustified. It’s not a vitamin, mineral, or another supplement—it’s a drug, so one must keep in mind that it can cause harm. Many people have mixed feelings about cyproheptadine, and I don’t blame them, because many people simply cannot benefit from it or don’t need it. First and foremost, I recommend trying a diet (especially one that limits protein—particularly tryptophan—and focuses on glycine and proline), as well as one rich in carbohydrates, because fats (especially oleic acid) have serotoninergic effects.