A combination of vitamin B1/B3/B7 and aspirin, has curative effects on human mantle-cell lymphoma
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@DavidPS said in A combination of vitamin B1/B3/B7 and aspirin, has curative effects on human mantle-cell lymphoma:
@Mauritio - Yes, it appears that he is not interested in patenting.
He selected the least expensive form of B1 to make his invention accessible to as many people as possible.
I am a registered patent attorney. I think he could obtain a patent based on the limited facts that I have. He solved a long-standing problem; that is a strong indication of patentability.
Ok in that case ,you know more about this than me.
Would be an interesting thing to ask him if he has any intentions on patenting it. -
@Ismail said in A combination of vitamin B1/B3/B7 and aspirin, has curative effects on human mantle-cell lymphoma:
Anyone watched Georgi’s interview on the strong sistas channel? He goes into discussing his study in quite some depth:
Thanks for posting , I was going to ask where he talked about it.
I'll watch it soon, but does he mention how he came on with using dihydrobenzoic acid ?
IIRC his methylene blue product contains benzoic acid ...Dare to think.
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I'm surprised Georgi didn't include B2 into the mix as well due to it's FNM/FAD qualities. The results are impressive nonetheless, but unless he's got a good reason for not including it I don't see why a human trying to replicate this couldn't do a B1/B2/B3/B7 + aspirin combo.
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@Mauritio talks about it at 21 mins (worked better than aspirin so far)
aspirin + 2,6 dihydroxybenzoic acid stopped progression but didnt regress,
2,6 alone without aspirin or b vits stopped & already showed regression
vitamins + aspirin or vitamins + 2,6 are in between, with the vitamins + 2,6 working better[btw in vivo benzoic acid as sodium benzoate has toxicity when you go to high milligram doses,
it crashes cholesterol , crashes blood cells induces anemia (weirdly after an initial increase) (maybe through lowering ceruloplasmin), skews electrolytes after 1 week, at dose ~200mg and ~600mg
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862570/bin/nihms193118f7.jpg
https://www.researchgate.net/publication/268298860_Effect_of_oral_intake_of_sodium_benzoate_on_some_haematological_parameters_of_wistar_albino_ratsmaybe the 2,6 form works different , (id think so because if it was crashing red blood cells significantly that would play into less co2 production and hinder the positive outcome)
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Thanks.
So the way I heard it, the following order emerges in terms of effectiveness, from high to low (mind you, the experiments are still ongoing):- 2,6 dihydroxybenzoic acid
- 2,6 dihydroxybenzoic acid + B Vitamins
- Aspirin + B Vitamins
- Aspirin + 2,6 dihydroxybenzoic acid
Dare to think.
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What is not clear to me is why the 2,6 dihydroxybenzoic acid is more effective without the vitamins, since they should only enhance the anti-cancer effect...
Dare to think.
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This is 2,6 dihydroxybenzoic acid :
<img src="https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/structures/196/724/160fee6b-8d74-427c-b54d-738933a5fa1c/800/160fee6b-8d74-427c-b54d-738933a5fa1c.png" alt="2,6-Dihydroxybenzoesäure 98%"/>this is aspirin (acetyl salicylic acid):
The structural similarity becomes even more obvious when you look at salicylic acid, which is where aspirins effects come and is called 2-hydroxybenzoic acid:
<img<img -
@Mauritio yeh thats odd
curious how well the b vits do alone (how much of the aspirin / 2,6 effect relies on extra carbonic anhydrase inhibition or a different mechanism if thiamine covers that?0extra carbonic anhydrase II inhibitors at nanogram concentration (as long as they dont mess with other aspects of mitochondria)
https://www.tandfonline.com/doi/full/10.3109/14756366.2011.593176 -
@Mulloch94 I thought the same; I can only surmise he was trying to use the least amount of ingredients to achieve the desired result/outcome
️@haidut fair assumption?
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@Ismail Probably so, I think if any of them are expendable it's probably B2, or B7. Both thiamine and niacin seem to be the "heavy-hitters" of the B vitamins.
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@cremes said in A combination of vitamin B1/B3/B7 and aspirin, has curative effects on human mantle-cell lymphoma:
@evan-hinkle said in A combination of vitamin B1/B3/B7 and aspirin, has curative effects on human mantle-cell lymphoma:
BTW, I'm serious about the latter part. As bioenergeticists, we believe that most/all diseases are brought about by broken or sub-optimal metabolism. If it's true, then this protocol should also serve to potentially solve type2 diabetes, heart disease, hypertension, IBS, dementia, alzheimers, OBESITY, and autoimmune diseases like MLS, Lupus, etc.
I have heart disease. I'm going to try this protocol and see what happens. I'm already taking B1, low-dose B3, and aspirin daily. I just need to adjust the amounts a bit and add in some biotin.
This morning I have started this protocol. If this helps restore my oxidative phosphorylation to youthful levels then not only does this cure cancer but it should broadly cure other metabolic diseases.
30 days starts now. I will re-evaluate ~June 15 assuming I don't run into an issue that forces me to abandon this early.
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@cremes good luck! Look forward to hearing your updates
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Yes @cremes and anyone else, good luck!
It does seem like a potential reset for some. Dosages may vary for certain people with different conditions imo. And a reminder to not deplete the other B vitamins or certain minerals while performing this protocol.
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Great Postings, @haidut and all here. Just a quick finding when I was checking (before travelling and buying food/supplies) on the internet some frozen fish at semi-nearby shops..... Seems the preservative 223 = Sodium Metabisulfite is used on frozen prawns/fish/seafood. !!! I was going to buy some frozen prawns (from Northern Australia), but has this additive.
So this form of Sulfite (or it's cousins in the same range) are just another additive to the already abundant use in the food industry.This below relates to the thread and the lack of B vitamins or the lack of the potential function of B vitamins in one's diet!
from https://www.fedup.com.au/factsheets/additive-and-natural-chemical-factsheets/220-228-sulphite-preservativesSulphites destroy thiamine (Vitamin B1) so some experts recommend that foods which are a significant source of thiamine, such as meats, dairy foods and cereals should not be sulphited. In Australia, a number of pet cats and dogs have died from thiamine deficiency due to a steady diet of pet meat containing unlisted sulphites. Since sulphites cleave the thiamine molecule, thiamine in vitamin supplements can also be destroyed by sulphites. For this reason, in the USA there has been a total prohibition on the use of sulphites in meats since 1959, although sulphited meats such as sausages are still widely eaten in other English and Spanish speaking countries. Sulphites are also thought to destroy folic acid.
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It's been a tad over 2 weeks since I started the protocol. I weight about 100kg so the math is really easy. I take 3 grams niacinamide, 1.5g thiamin Hcl, 1.5g aspirin, and 300mg biotin/b7 each morning. The aspirin is crushed into my morning Earl Grey tea along with 2 tbsp of honey. I eat the pills with water while the tea is steeping and then drink the tea over the course of about 20 minutes.
A few observations...
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I feel better
As a heart attack survivor of ~2 years, the first 18 months of it I had to get used to being out of breath from climbing stairs to the second story of my house. This annoyed me but I was acclimating. Since starting the protocol, my breathlessness has eased significantly. -
Warmth
I already take ~20mg of kuinone/K2 and 3x 2 drops of Tyromix each day. My temperatures were improving but were still sub-98F. Since starting the protocol, my waking temp is 98.4F routinely and during the day as I eat my ~300g of carbs I am measuring 99.4F at times.
I have not noticed any weight loss or body recomposition.
Will continue for at least 2 more weeks and then I'll decide if I will extend for another 30 days.
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@cremes It has now been another 30 days. I've remained on the protocol and feel mostly fine. Temperatures are still good. Weight is unchanged. Body comp is unchanged.
I've been seeking and getting ~7k IU of midday sun per day so I'm getting a nice tan. I have not noticed better sleep, weight loss, or other benefits. I assume my vit D status is low and I am now rebuilding it. I'll likely take a vitD blood test soon so I know where I'm at.
For a while there I thought maybe this protocol was improving some skin tags I have near my left and right armpits. However, while one or two tags "died off" the others are unchanged. I also had a mole on my right quad which has shrunken to almost nothing in the past 2 months. I am unsure if this is due to the protocol or due to the sun exposure.
I'm going to go another 30 days for a full 90 and then re-evaluate. I'm almost certain to take a break at that point. I imagine I should wean myself down over the course of 3-5 days instead of quitting everything cold turkey.
Sorry I don't have stronger benefits to report. I am unhappy about that too.
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@cremes thank you for the updates, genuinely much appreciated
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@Ismail Final update on this topic...
As promised above, I ran it for about another 30 days. So I did it from May 18 2024 through Aug 24 2024 which is 98 days. I then stepped down dosages over 8 days. I have continued with a daily baby aspirin (81mg) but otherwise the protocol is finished.
The benefits I noted in an earlier post remained through the end of the experiment. I don't believe I posted on this "benefit" but my alcohol tolerance was through the roof and I had no brain fog or other hangover the next day. I don't drink a lot anymore and usually limit myself to 1 or 2 drinks in a whole week; if I do 2 drinks at once I get a hangover. This protocol cured that.
Once I quit the protocol, my energy levels settled at a lower level again. My breathlessness on stair climbs also returned. My alcohol tolerance is worse than it's ever been, so other than a glass of wine once a week with my wife I don't even drink anymore. My favorite cocktails (sidecar, manhattan, gin martini) now make me feel terrible after just 1 of them.
I wish I had better news. At minimum, I'll say this protocol was safe for me but I see little reason to try it again any time soon.
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Hey guys, someone dear to me was recently diagnosed with pancreatic cancer. It's pretty severe with few options moving forward, so I'm going to give this b vitamin and aspirin protocol a try for her. I'm also thinking doxycycline, RU486, baking soda, and vitamin D, and maybe Progest-e and thyroid. Throwing everything at it.
Just wondering if anyone has experimented with this and had any insights overall. I don't want to overload her with a ton of things and cause more stress, but these all seem to be good ideas based on what I've learned here. Any thoughts would be greatly appreciated. Thank you.
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We know from Ray and other authors that thiamin, niacin, and aspirin have therapeutic potential in cancer. It seems that biotin was included in the combination without much consideration, and Jorge had access to more promising options already in his store.
I know that the priority is to nourish the person, but it's most effective when we limit nourishment to cancer cells. Biotin is a vitamin whose anabolic functions prevail, making supplementation a questionable intervention.
The assumption might have been that if pyruvate dehydrogenase (PDH) is inhibited, the alternative means to metabolize pyruvate away from lactate would be with the biotin-dependent pyruvate carboxylase (PC) to oxaloacetate.
Mitochondria are not just energy-producing organelles, they're also biosynthetic sites, with pyruvate carboxylase having an important role in this anabolic picture.
Oxaloacetate can help to export excess mitochondrial acetyl-CoA (that reinforces PDH inhibition and stimulates PC). This acetyl-CoA can then be used to synthesize fats in the cytosol, a process that's started by acetyl-CoA carboxylase (ACC)--another biotin-dependent enzyme.
Roles of pyruvate carboxylase in human diseases: from diabetes to cancers and infection
Yes, PC-derived oxaloacetate can refill the TCA cycle, but so does ketoglutarate from glutamate or glutamine, and they can cooperate.
Two other biotin-dependent enzymes (MCC and PCC) are involved in amino acid metabolism and can also channel the products to refill the cycle. These products would enter the TCA cycle right where ATP is synthesized through substrate-level phosphorylation (Tommy), with higher chances of bypassing inhibitions.
Therefore, all 4 biotin enzymes can converge in anabolic processes that may be problematic in the context of cancer.
To compound the concerns, simple conversion of pyruvate to oxaloacetate is one step away from aspartate synthesis, needed for the upregulated nucleotide synthesis.
This aspartate can also participate in the malate-aspartate shuttle, that serves to import cytosolic NADH. Normally, oxalate is formed from malate, but if this is reversed with the help of pyruvate carboxylase, the shuttle could perhaps work in reverse, and it would contribute to the export of NADH, with higher cytosolic NADH/NAD⁺ promoting lactate synthesis. In addition, it can be an alternative way to regenerate NAD⁺ when respiratory complexes are compromised, to allow the TCA cycle to keep functioning.
In fairness, some of these processes concentrate in liver and kidneys, and biotin may also relieve the burden in supporting clearance of excess lactate from cancerous tissues (lactate → pyruvate –B7→ oxaloacetate → pyruvate enolphosphate →→ glucose), possibly more so than thiamin, as local pyruvate oxidation without redistribution as glucose could perhaps overwhelm such organs. However, thiamin could be of better service for other tissues, that clear lactate through complete oxidation.
Even in cases where biotin supplementation normalizes glucose metabolism, the anabolic component can't be discarded.
Some Aspects of Carbohydrates Metabolism in Biotin-Deficient Rats
"It is possible, therefore, that these changes in the fatty acid composition of the lipid might alter the structural integrity of mitochondria with the consequent effect on oxidative phosphorylation. This defect, as reflected by amino acid incorporation studies, was compensated during early stages of the deficiency when the animals received an oxidizable substrate such as succinate (see reference 1) or fructose or sorbitol in the basal diet. It is, therefore, possible that a moderate decrease in oxidative phosphorylation does not limit the efficiency of the biotin-deficient animal as long as adequate levels of oxidizable substrates are maintained. However, in advanced deficiency as observed after 8 weeks on the deficient diet, succinate, sorbitol, or fructose feeding did not help the animal. Only administration of biotin restwed fatty acid synthesis and the integrity of mitochondria for normal oxidative phosphorylation."
It's no wonder that symptoms of biotin deficiency point to anabolic defects, such as disturbed skin lipids.
I would be careful with its supplementation in advanced cancer and observe reactions. It's preferable to avoid B-vitamins formulas and have the vitamins separately for better control.
This is not to suggest that thiamin, niacin, and aspirin are entirely beneficial in cancer because they're not, but their positive outweigh negative effects. Biotin isn't invariably problematic, but seems riskier.
