Ergothioneine - amino acid for life extension.
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@cs3000 said in Ergothioneine - amino acid for life extension.:
very nice, thanks. love to see it when studies include solo groups vs normal controls, that catalase increase is wild
Yes, me too. Also interesting that Ive never come across this amino acid, ever. No mention of it on the RPF as well. Yet it has been known for at least a century.
Absolutely, and the overexpression of CAT to mitochondria also resulted in an increase in life span of about 20% IIRC, so that might be the most important factor here.@cs3000 said in Ergothioneine - amino acid for life extension.:
(builds up over time, glutathione helps recycle it)
Yes, that is noteworthy that the body likes to retain it as much as possible. Almost as if it would store it for when times are bad. Which is why some scientists call it a "stress vitamin" because it is needed in times of stress otherwise not so much. Hence why knockout animals only experience issues when they are stressed.
@cs3000 said in Ergothioneine - amino acid for life extension.:
the half life on this thing lol wtf "It is not metabolized to any notable extent in mammalian tissues, the half-life of dietary ET being approximately 1 month" , very curious compound
Wow, although yesterday I read that while there is only 4% excretion , they found two likely metabolites. But not sure anymore where I read that.
@cs3000 said in Ergothioneine - amino acid for life extension.:
Its cycling between oxidized and reduced
That's exactly what methylene blue is doing as well.
I would just go for the supplement ,otherwise you'd have to eat a ton of mushrooms everyday. And I dont think I had any major issues with cellulose. And for trying it out ,it should be ok.I can only find the life extension supplement .
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@cs3000 said in Ergothioneine - amino acid for life extension.:
https://www.biorxiv.org/content/10.1101/2024.04.10.588849v1.full
And that was after 2 weeks only.
"On average control diet-fed mice ran 0.73 km per hour during the dark phase of an entire week, while EGT diet-fed mice ran 0.87 km per hour, reflecting a ∼19% increase in exercise performance during their active phase (Fig. 4B). Moreover, at peak activity EGT diet-fed mice were able to run ∼28% faster (Average 24.8 m per min) than control diet-fed mice (Average 19.4 m per min) (Fig. 4C, Fig. S4B)."
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Interesting that bacteria can break down AND synthesize ergothioneine, depending on the type of baceria.
"Herein we describe two enzymes from actinobacteria that cooperate in the specific oxidative degradation of ergothioneine. The first enzyme is an iron-dependent thiol dioxygenase that produces ergothioneine sulfinic acid. A crystal structure of ergothioneine dioxygenase from Thermocatellispora tengchongensis reveals many similarities with cysteine dioxygenases, suggesting that the two enzymes share a common mechanism. The second enzyme is a metal-dependent ergothioneine sulfinic acid desulfinase that produces Nα-trimethylhistidine and SO2 . The discovery that certain actinobacteria contain the enzymatic machinery for O2 -dependent biosynthesis and O2 -dependent degradation of ergothioneine indicates that these organisms may actively manage their ergothioneine content."
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"...hippocampal neurogenesis were lower in mice fed an ERGO-free diet than in those fed the control diet. Furthermore, ERGO supplementation to achieve the control diet ERGO levels reversed these effects and restored ERGO concentrations in the plasma and hippocampus."
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ERGO can protect against social defeat.
"...ergothioneine prior to and during the SDS (social defeat stress) paradigm had a preventative effect on SDS-induced depressive behaviors, such as social avoidance and depression-like sleep abnormalities, particularly those of rapid eye movement sleep."
Not only that, I already mentioned that some gut bacteria can synthesize ergothioneine. One of them is L. Reuteri. It can increase testosterone dramatically and is anti-inflammatory. Well, another benefit can be added to the list now! Hans made an interesting video on it.
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I took my first tablet yesterday.
It increases muscle fullness and I am feeling more androgenic. I think it is good for liver health. Had some bile dumps and felt a sense of relief after.
I am currently adjusting my thyroid dosage and everbody who did that before knows that can be a pain in the ass and you might have to go through a few days of suboptimal thyroid function. Ergothioneine definitely helped with that and relieved the low mood and lethargy associated with hypothyroidism. It also made me more active during the day, but sleep was very refreshing.
Verbal fluency seems increased.
The only downside is hair loss is a bit increased. But not strongly.I can only encourage people to try it. Given its long half life it might be taken only 1 or twice a week since the body accumulates it similarly to the fat soluble vitamins.
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Ergothioneine: A Stress Vitamin with Antiaging, Vascular, and Neuroprotective Roles?
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@wrl said in Ergothioneine - amino acid for life extension.:
Ergothioneine: A Stress Vitamin with Antiaging, Vascular, and Neuroprotective Roles?
Good one.
It also seems to have cosmetic benefits .
"ET accumulates in skin cells and not only prevents oxidative damage but also facilitates DNA repair in UV-irradiated cells (80). For these reasons, ET has been included as an ingredient in several skin care products and cosmetics."
Dare to think.
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M Mauritio referenced this topic on
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@Mauritio bud, you still taking this? If so, how’s it going? Which brand/product are you taking?
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I've only tried it a few times. It felt pretty good, but unfortunately increased my hair loss.
Dare to think.
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@Mauritio oh no! Sorry to hear that bud! I guess you had no choice but to stop.
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@Mauritio said in Ergothioneine - amino acid for life extension.:
I've only tried it a few times. It felt pretty good, but unfortunately increased my hair loss.
I wonder whether this could be related to the glutathione system. Perhaps that needs to step up accordingly. Would some 1:1 Glycin and NAC and some xx mg ascorbic acid do the trick?
If that hair loss for you really knocks through within only two days of taking ET it's an undesired but actually very convenient marker. -
I get mine from L-reuteri (see) and I have not had any negative side effects.
Store bought mushrooms are most likely grown in manure contaminated with waste from industrial processing of cattle and the like.
