Olive leaf extract increases T3 + T4, lowers TSH
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Good news for olive oil enthusiasts. Recently I posted about the strong anti-cancer effects of one of olive oil's compounds called oleocanthal (https://bioenergetic.forum/post/36395)
Now in this study the researchers looked at olive leaf extract.
The researchers thought it increased t3 by speeding up T4 → T3 conversion. But as you can see in the table below, T4 also increased and TSH was only ¼ the value of the control group.
T3 was even increased by 2.5 times!
And as the article mentions those HED' s are easily achievable with cheap OTC supplements"The researchers gave male rats weighing 125-150 g homemade water-based Olive Leaf Extract orally for 14 days. The maximal dose was 0.5 mg per day. That works out at 4 mg per kg bodyweight. For humans, that would be about 50 mg extract per day. That's not a lot. Drug stores sell capsules containing 150 mg Olive Leaf Extract."
https://www.ergo-log.com/olive-leaf-extract-active-thyroid-hormone.html
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lt gets even better:oleurupin is a carbonic anhydrase inhibitor-both isoenzymes. So it increases CO2 retention in the body.It's not quite as strong as acetazolamide,but it is pretty good for a natural phenol.
https://pubmed.ncbi.nlm.nih.gov/34483220/Speaking of which there is a study that screened a few natural substances for the same activity, unfortunetly i cant get the full-text, but it includes some interesting substances like apigenin or
caffeic acid. Apigenin has been shown to be a carbonic anhydrase inhibitor in other studies already.
https://pubmed.ncbi.nlm.nih.gov/35306678/ -
Here's another study showing Oleuropein's pro- thyroid effect. It increased T3 and T4 in BPA-treated rats, while lowering TSH. It also had an anabolic effect on the bone.
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Seems great but if it is so great what can we expect to be the downsides?