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    Reversal of hair loss in Mice with “sugar gel”

    Literature Review
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    • serotoninskepticS
      serotoninskeptic @Hando-Jin
      last edited by

      @Hando-Jin Do you have a quote?

      W Hando-JinH 2 Replies Last reply Reply Quote 0
      • W
        wester130 @serotoninskeptic
        last edited by

        did anyone buy it from ebay?

        1 Reply Last reply Reply Quote 0
        • M
          Moonpeat @LetTheRedeemed
          last edited by

          @LetTheRedeemed Have you seen any improvement since your last update?

          L 1 Reply Last reply Reply Quote 0
          • Hando-JinH
            Hando-Jin @serotoninskeptic
            last edited by

            @Serotoninskeptic

            "Ray Peat: I've been thinking that with a concentrated glucose solution, you could probably activate hair growth just by keeping your scalp moistened with glucose."

            https://dannyroddy.substack.com/p/lost-conversations-with-ray-peat

            MauritioM 1 Reply Last reply Reply Quote 0
            • L
              LetTheRedeemed @Moonpeat
              last edited by

              @Moonpeat, hey, I essentially gave up after 3 weeks. I realized that as much as I may not like it, I have more pressing health issues to fix first

              1 Reply Last reply Reply Quote 0
              • MauritioM
                Mauritio
                last edited by

                I want to mention the anti-prolactin angle again on this thread.
                I think applying an anti-prolactin chemical topically to the scalp , should be very effective.
                I'm thinking about lisuride, bromocriptine or 5aDHP, which isn't just anti-prolactin but also a progestogen so even better.

                Dare to think.

                My X:
                x.com/Metabolicmonstr

                GastonG 1 Reply Last reply Reply Quote 0
                • GastonG
                  Gaston @Mauritio
                  last edited by

                  @Mauritio I've been applying bromocriptine to my scalp on an irregular basis for quite awhile and I can't say that it's produced any miracles.

                  MauritioM 1 Reply Last reply Reply Quote 0
                  • MauritioM
                    Mauritio @Gaston
                    last edited by

                    @Gaston Ok.
                    I've even wondering about topical lidocaine as well. It is anti prolactin and anti inflammatory .

                    Dare to think.

                    My X:
                    x.com/Metabolicmonstr

                    W 1 Reply Last reply Reply Quote 0
                    • W
                      wester130 @Mauritio
                      last edited by

                      @Mauritio said in Reversal of hair loss in Mice with “sugar gel”:

                      lidocaine

                      would a gel work?

                      MauritioM 1 Reply Last reply Reply Quote 0
                      • MauritioM
                        Mauritio @wester130
                        last edited by

                        @wester130 not sure , what are the exact ingredients ?

                        Dare to think.

                        My X:
                        x.com/Metabolicmonstr

                        W 1 Reply Last reply Reply Quote 0
                        • W
                          wester130 @Mauritio
                          last edited by

                          @Mauritio

                          alcohol, clove oil, glycerol, hydroxypropyl cellulose, sodium
                          saccharin, Ponceau 4R (E124) and purified water.

                          MauritioM 1 Reply Last reply Reply Quote 0
                          • MauritioM
                            Mauritio @wester130
                            last edited by

                            @wester130
                            I would simply use lidocaine dissolved in water since it's widely available in most countries.

                            Have you tried the NMN topically ?

                            Dare to think.

                            My X:
                            x.com/Metabolicmonstr

                            W MauritioM A 3 Replies Last reply Reply Quote 0
                            • W
                              wester130 @Mauritio
                              last edited by

                              @Mauritio i think menthol anhd liodcaine share some properties

                              MauritioM 1 Reply Last reply Reply Quote 0
                              • MauritioM
                                Mauritio @wester130
                                last edited by

                                @wester130 what kind of answer is this ? Lol

                                But since we're taking menthol it has some anti testosterone/estrogenic effects

                                https://bioenergetic.forum/post/38971

                                Dare to think.

                                My X:
                                x.com/Metabolicmonstr

                                W 1 Reply Last reply Reply Quote 0
                                • W
                                  wester130 @Mauritio
                                  last edited by

                                  @Mauritio could you use anbesol?

                                  1 Reply Last reply Reply Quote 0
                                  • MauritioM
                                    Mauritio @Mauritio
                                    last edited by

                                    @Mauritio said in Reversal of hair loss in Mice with “sugar gel”:

                                    Have you tried the NMN topically ?

                                    @wester130

                                    Dare to think.

                                    My X:
                                    x.com/Metabolicmonstr

                                    W 1 Reply Last reply Reply Quote 0
                                    • W
                                      wester130 @Mauritio
                                      last edited by

                                      @Mauritio yes, not sure it did anything

                                      1 Reply Last reply Reply Quote 0
                                      • MauritioM
                                        Mauritio @Hando-Jin
                                        last edited by Mauritio

                                        @Hando-Jin said in Reversal of hair loss in Mice with “sugar gel”:

                                        @Serotoninskeptic

                                        "Ray Peat: I've been thinking that with a concentrated glucose solution, you could probably activate hair growth just by keeping your scalp moistened with glucose."

                                        https://dannyroddy.substack.com/p/lost-conversations-with-ray-peat

                                        "...excessive glucose is able to increase the expression of hair inductive genes and elongation of hair shaft."
                                        https://pmc.ncbi.nlm.nih.gov/articles/PMC7078220/

                                        In the above study they used a concentration of 10mM to boost hair growth and mimick excessive glucose . That is just 180mg per 100ml . The issue is that the hair shaft sot relatively deep in the scalp and not much /everything will reach the shaft so to account for the loss i would go for 50mM or approximately 1g or 1% of glucose per 100ml .

                                        EDIT : just saw they used d-glucose aka Dextrose . I wanted to use sucrose (table sugar) but I don't think sucrose can substitute as the scalp lacks the enzymes to split up table sugar into glucose and fructose and sucrose is a much bigger molecule, making absorption even trickier

                                        On top of that i would use 30% percent alcohol and 10% propylene glycol which sterilize the solution and help absorption and penetration. This is inspired by the formula of Minoxidil, which seems to be absorbed well.

                                        So the updated formula would look like this :

                                        30% ethanol
                                        10% propylene glycol
                                        1% NMN
                                        1% Apple polyphenols
                                        1% of dextrose
                                        Rest: Water

                                        (add taurine ,caffeine,... to your liking)

                                        Total Solids:

                                        • Dextrose: 1 g
                                        • Apple Peel Polyphenols: 1 g
                                        • NMN: 1 g
                                        • Total: 3 g

                                        Total Liquids:

                                        • Water: 70 mL
                                        • Ethanol: 20 mL
                                        • Propylene Glycol: 10 mL
                                        • Total: 100 mL

                                        @Gaston

                                        Dare to think.

                                        My X:
                                        x.com/Metabolicmonstr

                                        A GastonG L 4 Replies Last reply Reply Quote 0
                                        • MauritioM
                                          Mauritio
                                          last edited by Mauritio

                                          Interesting. The hair follicle seems to be use mostly aerobic glycolisis for energy production.

                                          "...the hair follicle exhibits aerobic glycolysis, in that of the total glucose utilized by the hair follicle, only 10% is oxidized to CO2."

                                          https://pubmed.ncbi.nlm.nih.gov/2045676/

                                          This study goes hand in hand with the one above. It shows that hair follicles have their one corri cycle (producing glucose out of lactate) which makes sense since they're using mainly aerobic glycolisis, which provides lots of lactate as a waste product . They use that lactate and form glycogen out of it! Which in turn helps keep the hair follicle in anagen growing phases.

                                          So if the hair can use lactate to make glycogen surely it can use glucose.
                                          Usually glucose can either be directly metabolized to energy or converted to G6P via hexokinase serving as a building block for glyocgen .Which makes the glucose hypothesis even more attractive because the supply of glucose wouldn't have to be constant (which isn't realistic anyway) since the hair can synthesize glycogen and store it for when glucose levels drop, keeping the hair in an anagen phase.

                                          https://pmc.ncbi.nlm.nih.gov/articles/PMC8531296/

                                          Dare to think.

                                          My X:
                                          x.com/Metabolicmonstr

                                          MauritioM 1 Reply Last reply Reply Quote 0
                                          • MauritioM
                                            Mauritio
                                            last edited by Mauritio

                                            This study suggests that the higher G6PD is the more anagen hairs you have.

                                            G6PD creates R5P (ribose-5-phosphate).

                                            This might be why ribose could work.
                                            Because ribose is also converted to R5P.
                                            If you already have more R5P, you need to convert less G6P into it, and thus leaves more for glyocgen synthesis. So ribose indirectly increases glyocgen levels.

                                            Or it could have to do with nucleotide synthesis .
                                            R5P is used for it and maybe nucleotide Synthesis is an overlooked player in hair loss ? Haven't looked into it.

                                            Makes me wonder if I should add some ribose to the above formula...

                                            https://pubmed.ncbi.nlm.nih.gov/10664855/

                                            Dare to think.

                                            My X:
                                            x.com/Metabolicmonstr

                                            1 Reply Last reply Reply Quote 0
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