Reversal of hair loss in Mice with “sugar gel”
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@LetTheRedeemed I don't want to influence you too much because I'm honestly not very knowledgeable. You can continue using urea; just make sure to report back to us if it seems to harm your hair density.
I'm getting slight regrowth on my temples, but that could be due to a dozen different factors.
I use C-Salts Buffered vitamin C. I can't recommend it for any particular reason, it's just what I've always used.
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@Gaston gotcha. Thanks for sharing.
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@Hando-Jin Do you have a quote?
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did anyone buy it from ebay?
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@LetTheRedeemed Have you seen any improvement since your last update?
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"Ray Peat: I've been thinking that with a concentrated glucose solution, you could probably activate hair growth just by keeping your scalp moistened with glucose."
https://dannyroddy.substack.com/p/lost-conversations-with-ray-peat
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@Moonpeat, hey, I essentially gave up after 3 weeks. I realized that as much as I may not like it, I have more pressing health issues to fix first
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I want to mention the anti-prolactin angle again on this thread.
I think applying an anti-prolactin chemical topically to the scalp , should be very effective.
I'm thinking about lisuride, bromocriptine or 5aDHP, which isn't just anti-prolactin but also a progestogen so even better. -
@Mauritio I've been applying bromocriptine to my scalp on an irregular basis for quite awhile and I can't say that it's produced any miracles.
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@Gaston Ok.
I've even wondering about topical lidocaine as well. It is anti prolactin and anti inflammatory . -
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@wester130 not sure , what are the exact ingredients ?
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alcohol, clove oil, glycerol, hydroxypropyl cellulose, sodium
saccharin, Ponceau 4R (E124) and purified water. -
@wester130
I would simply use lidocaine dissolved in water since it's widely available in most countries.Have you tried the NMN topically ?
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@Mauritio i think menthol anhd liodcaine share some properties
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@wester130 what kind of answer is this ? Lol
But since we're taking menthol it has some anti testosterone/estrogenic effects
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@Mauritio could you use anbesol?
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@Mauritio said in Reversal of hair loss in Mice with “sugar gel”:
Have you tried the NMN topically ?
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@Mauritio yes, not sure it did anything
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@Hando-Jin said in Reversal of hair loss in Mice with “sugar gel”:
"Ray Peat: I've been thinking that with a concentrated glucose solution, you could probably activate hair growth just by keeping your scalp moistened with glucose."
https://dannyroddy.substack.com/p/lost-conversations-with-ray-peat
"...excessive glucose is able to increase the expression of hair inductive genes and elongation of hair shaft."
https://pmc.ncbi.nlm.nih.gov/articles/PMC7078220/In the above study they used a concentration of 10mM to boost hair growth and mimick excessive glucose . That is just 180mg per 100ml . The issue is that the hair shaft sot relatively deep in the scalp and not much /everything will reach the shaft so to account for the loss i would go for 50mM or approximately 1g or 1% of glucose per 100ml .
EDIT : just saw they used d-glucose aka Dextrose . I wanted to use sucrose (table sugar) but I don't think sucrose can substitute as the scalp lacks the enzymes to split up table sugar into glucose and fructose and sucrose is a much bigger molecule, making absorption even trickier
On top of that i would use 30% percent alcohol and 10% propylene glycol which sterilize the solution and help absorption and penetration. This is inspired by the formula of Minoxidil, which seems to be absorbed well.
So the updated formula would look like this :
30% ethanol
10% propylene glycol
1% NMN
1% Apple polyphenols
1% of dextrose
Rest: Water
(add taurine ,caffeine,... to your liking)Total Solids:
- Dextrose: 1 g
- Apple Peel Polyphenols: 1 g
- NMN: 1 g
- Total: 3 g
Total Liquids:
- Water: 70 mL
- Ethanol: 20 mL
- Propylene Glycol: 10 mL
- Total: 100 mL