Reversal of hair loss in Mice with “sugar gel”

Mauritio

@CrumblingCookie said in Reversal of hair loss in Mice with “sugar gel”:

It's just a thought for avoiding the degree of scalp skin disinfection from the ethanol or its alternative of 20-30% propylene glycol. Of which I cannot say how much significance that bears wrt to the skin microbiome.
What's the minimum ethanol concentration for enhancement of absorption?

I don't remember the minimal concentration but I remember it should have been even a bit higher than it is now, especially since removing propylene glycol and especially for the apple polyphenols /procyanidins.

I'm not sure the scalp disinfection is a negative thing.
The fungal hypothesis seems more and more reasonable to me and ethanol does have anti fungal effects.

https://www.tandfonline.com/doi/abs/10.1080/00393630.2015.1137428

This is where the issue with benzoic acid comes in, fungi thrive in low pH environments and if benzoic acids needs that as well, that might not work well.
In fact, potassium bicarbonate is really good at increasing the pH, which is part of its anti fungal effect. So Ill probably be adding this soon . Only topically though, since I don't want to neutralize stomach acid.

@CrumblingCookie said in Reversal of hair loss in Mice with “sugar gel”:

Ah well yes sir/m'lady, the results of laboratory analysis of your painfully plucked hairs are in: They are telogen and falling out and we advice you take this agent of chemical castration, brain neurotransmitter and collagen degeneration" - "Gee, thank you, doc. I better heed this because, boy, I really wouldn't know what to do without your great sophistication!"

Lol

@CrumblingCookie said in Reversal of hair loss in Mice with “sugar gel”:

Might as well choose lactic acid for that instead?

That's a good point . at a low concentration there shouldn't be any systemic effects. So lactate seems interesting.

Mauritio

@AinmBeo yes I looked into that yesterday. And I'll be going for "drinkable" food grade alcohol. It's more expensive, but the other alcohol is purposefully made un-drinkable with a bunch of additives.

AinmBeo

@Mauritio
Yes.
I see a lot of food grade 190 proof sugar cane-based ethanol on amazon. I base that "food grade 190 proof sugar cane-based ethanol" choice on comments on the Peat site about this very issue. That looks right.
But I am going to the local ETOH store (right next to the pot store...next to the cigarette store) to see, is their Everclear 190 proof food grade ETOH cheaper than the same type of amazon product.

Mauritio

Here's a bunch of people that claim harder water , containing more calcium carbonate, making their hair more healthy .

Interesting observation . Maybe it's the alkaline pH of the carbonate making it anti-fungal?

My hair has drastically lost health and thickness since moving to a city with soft water. Any ways to make my water harder?
https://www.reddit.com/r/Haircare/s/e1hgEg4eHL

Mauritio

I have added potassium bicarbonate to the formula at 0.5% .

Updated formula

D-Glucose: 1%
Apple Peel Polyphenols: 1%
NMN: 1%
Sodium Butyrate: 0.075%
Potassium Bicarbonate: 0.5%
Ethanol: 35%
Water: 65%

NoeticJuice

@Mauritio said in Reversal of hair loss in Mice with “sugar gel”:

Any ways to make my water harder?

Putting it in the freezer might help

On a more serious note, I think there are some shower filters that add calcium and magnesium to the water.

Mauritio

@CrumblingCookie

RPF forum member tyw seemed to somewhat agree . At least he saw lactate as the perfect brain fuel. Maybe that's true for hair as well.

Perhaps tissues that are sensitive to peroxidative damage do well with anaerobic glycolisis and using lactate ?!

"NOTE: the brain heavily regulates oxygen delivery to various tissues, and if those processes are disrupted, we can get over-oxygenation and therefore peroxidation of many brain components.
...
SIDENOTE AGAIN: this is one of the reasons I am a supporter of the theory that Lactate is the ideal brain fuel."

https://lowtoxinforum.com/threads/tyw-said-something-that-makes-alot-of-sense.15816/post-217831

"Elevated ROS levels in hair follicle cells during the catagen phase facilitate hair follicle degeneration through the regulation of Trx1 and Foxp1 (Zhao et al., 2015). Balding scalps exhibits increased levels of ROS in the dermal papillae compared to non-balding scalps (Shin et al., 2013; Bakry et al., 2014)."
https://www.biomolther.org/journal/view.html?uid=1565&vmd=Full&